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Coreviewers
Anca Savulescu CSIR
3 protocols

Annis Richardson UC Berkeley
3 protocols

Antoine de Morree Stanford university
23 protocols

Benoit Chassaing Clermont Université, Université d'Auvergne, M2iSH, UMR 1071 INSERM, UNC 2018 INRA, France
11 protocols

Gal Haimovich
  • Post-Doc, Weizmann Institute of Science
Research focus
  • Cell biology
  • mRNA localization, mRNA transfer, membrane nanotubes, exosomes
Contributions
  • 2 Reviewer merit
  • 18 Editor merit

Education

PhD, Technion - Israeli institute of technology, 2011

Lab information

Jeffrey Gerst lab http://www.weizmann.ac.il/molgen/Gerst/
We are studying protein and mRNA localization in eukaryotic cells (mainly yeast & mammalian cells).
http://www.weizmann.ac.il/molgen/Gerst/

Publications

1. Haimovich G., Zabezhinsky D., Haas B., Slobodin B., Purushothaman P., Lin F., Levin JZ., Nusbaum C. and Gerst JE. (2016) Use of the MS2 aptamer and coat protein for RNA localization in yeast: A response to “MS2 coat protein bound to yeast mRNAs block 5’ to 3’ degradation and trap mRNA decay products: implications for the localization of mRNAs by MS2-MCP system” RNA, 22:660-666..
2. Haimovich G., Cohen-Zontag O. and Gerst JE. (2016) A role for mRNA trafficking and localized translation in peroxisome biogenesis and function? Biochem. Biophys. Acta - Molecular Cell Research, 1863(5):911-921.
3. Buxbaum AR*., Haimovich G*. and Singer RH. (2015) In the right place at the right time: visualizing and understanding mRNA localization. Nature Reviews Molecular Cell Biology, 16:95-109. * - equal contribution.
4. Somekh J., Haimovich G., Guterman A., Choder M. and Dori D. (2014) Conceptual Modeling of mRNA decay provokes new hypotheses. PLoS One, 9(9): e107085.
5. Haimovich G., Medina D., Causse S., Garber M., Millan-Zambrano G., Barkai O., Chavez S., Perez-Ortin JE., Darzacq X. and Choder M. (2013) Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis. Cell, 153(5):1000-1011.
6. Haimovich G., Singer RH., Choder M. and Trcek T. (2013) The fate of the messenger is pre-determined: a new model for regulation of gene expression. Biochem. Biophys. Acta - Gene Regulatory Mechanisms, 1829(6-7):643-653.
7. Harel-Sharvit L., Eldad N., Haimovich G., Barkai O., Duek L. and Choder M. (2010) RNA polymerase II subunits link transcription and mRNA decay to translation. Cell, 143(4):552-563.
8. Goler Bar-On V., Selitrennik M., Barkai O., Haimovich G., Lotan R. and Choder M. (2008) Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes. Genes and Development, 22:2022-2027.
9. Lotan R., Goler Bar-On V., Duek L., Haimovich G. and Choder M. (2007) The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms. J. Cell Biology, 178(7):1133-1143.
10. Kamer I., Sarig R., Zaltsman Y., Niv H., Oberkovitz G., Regev L., Haimovich G., Lerenthal Y., Marcellus R. C. and Gross A. (2005) Pro-apoptotic BID is an ATM effector in the DNA damage response. Cell, 122(4):593-603.
11. Weiss M., Haimovich G. and Pick U. (2001) Phosphate and Sulfate uptake in the halotolerant alga Dunaliella are driven by Na+-symport mechanism. J. Plant Physiology, 158:1519-1525.

2 Protocols reviewed
Formation of Minimised Hairpin Template-transcribing Dumbbell Vectors for Small RNA Expression
Authors:  Xiaoou Jiang and Volker Patzel, date: 06/05/2017, view: 884, Q&A: 0
A major barrier for using non-viral vectors for gene therapy is the short duration of transgene expression in postmitotic tissues. Previous studies showed transgene expression from conventional plasmid fell to sub-therapeutic level shortly after ...
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A Golden Gate-based Protocol for Assembly of Multiplexed gRNA Expression Arrays for CRISPR/Cas9
The CRISPR (clustered regularly interspaced short palindromic repeats)-associated protein 9 (Cas9) has become the most broadly used and powerful tool for genome editing. Many applications of CRISPR-Cas9 require the delivery of multiple small guide ...
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18 Protocols edited
Nuclei Isolation from Nematode Ascaris
Authors:  Yuanyuan Kang, Jianbin Wang and Richard E. Davis, date: 05/05/2017, view: 1095, Q&A: 0
Preparing nuclei is necessary in a variety of experimental paradigms to study nuclear processes. In this protocol, we describe a method for rapid preparation of large number of relatively pure nuclei from Ascaris embryos or tissues that are ...
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Single Molecule RNA FISH in Arabidopsis Root Cells
Authors:  Susan Duncan, Tjelvar S. G. Olsson, Matthew Hartley, Caroline Dean and Stefanie Rosa, date: 04/20/2017, view: 1472, Q&A: 0
Methods that allow the study of gene expression regulation are continually advancing. Here, we present an in situ hybridization protocol capable of detecting individual mRNA molecules in plant root cells, thus permitting the accurate ...
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