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Coreviewers
Anca Savulescu The Council for Scientific and Industrial Research
3 protocols

Annis Richardson University of California, Berkeley
3 protocols

Antoine de Morree Stanford university
27 protocols

Benoit Chassaing Georgia State University
11 protocols

Editor
Gal Haimovich
  • Post-Doc, Weizmann Institute of Science
Research focus
  • Cell biology
  • mRNA localization, mRNA transfer, membrane nanotubes, exosomes
  • 0 Author merit

Education

PhD, Technion - Israeli institute of technology, 2011

Lab information

Jeffrey Gerst lab http://www.weizmann.ac.il/molgen/Gerst/
We are studying protein and mRNA localization in eukaryotic cells (mainly yeast & mammalian cells).
http://www.weizmann.ac.il/molgen/Gerst/

Publications

1. Weiss M., Haimovich G. and Pick U. (2001) Phosphate and Sulfate uptake in the halotolerant alga Dunaliella are driven by Na+-symport mechanism. J. Plant Physiology, 158:1519-1525.
2. Kamer I., Sarig R., Zaltsman Y., Niv H., Oberkovitz G., Regev L., Haimovich G., Lerenthal Y., Marcellus RC. and Gross A. (2005) Pro-apoptotic BID is an ATM effector in the DNA damage response. Cell, 122(4):593-603.
3. Lotan R., Goler Bar-On V., Duek L., Haimovich G. and Choder M. (2007) The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms. J. Cell Biology, 178(7):1133-1143.
4. Goler Bar-On V., Selitrennik M., Barkai O., Haimovich G., Lotan R. and Choder M. (2008) Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes. Genes and Development, 22:2022-2027.
5. Harel-Sharvit L., Eldad N., Haimovich G., Barkai O., Duek L. and Choder M. (2010) RNA polymerase II subunits link transcription and mRNA decay to translation. Cell, 143(4):552-563.
6. Haimovich G., Singer RH., Choder M. and Trček T. (2013) The fate of the messenger is pre-determined: a new model for regulation of gene expression. Biochem. Biophys. Acta - Gene Regulatory Mechanisms, 1829(6-7):643-653.
7. Haimovich G., Medina D., Causse S., Garber M., Millan-Zambrano G., Barkai O., Chavez S., Perez-Ortin JE., Darzacq X. and Choder M. (2013) Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis. Cell, 153(5):1000-1011.
8. Somekh J., Haimovich G., Guterman A., Choder M. and Dori D. (2014) Conceptual Modeling of mRNA decay provokes new hypotheses. PLoS One, 9(9): e107085.
9. Buxbaum AR. *, Haimovich G. * and Singer RH. (2015) In the right place at the right time: visualizing and understanding mRNA localization. Nature Reviews Molecular Cell Biology, 16:95-109. * - first co-author (equal contribution).
10. Haimovich G., Cohen-Zontag O. and Gerst JE. (2016) A role for mRNA trafficking and localized translation in peroxisome biogenesis and function? Biochem. Biophys. Acta - Molecular Cell Research, 1863(5):911-921.
11. Haimovich G., Zabezhinsky D., Haas B., Slobodin B., Purushothaman P., Lin F., Levin JZ., Nusbaum C. and Gerst JE. (2016) Use of the MS2 aptamer and coat protein for RNA localization in yeast: A response to “MS2 coat protein bound to yeast mRNAs block 5’ to 3’ degradation and trap mRNA decay products: implications for the localization of mRNAs by MS2-MCP system”. RNA, 22:660-666.
12. Haimovich G., Ecker CM., Dunagin MC., Eggan E., Raj A., Gerst JE. and Singer RH. (2017) Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells. PNAS, 114(46): E9873–E9882.

2 Protocols reviewed
Formation of Minimised Hairpin Template-transcribing Dumbbell Vectors for Small RNA Expression
Authors:  Xiaoou Jiang and Volker Patzel, date: 06/05/2017, view: 1207, Q&A: 0
A major barrier for using non-viral vectors for gene therapy is the short duration of transgene expression in postmitotic tissues. Previous studies showed transgene expression from conventional plasmid fell to sub-therapeutic level shortly after ...
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A Golden Gate-based Protocol for Assembly of Multiplexed gRNA Expression Arrays for CRISPR/Cas9
The CRISPR (clustered regularly interspaced short palindromic repeats)-associated protein 9 (Cas9) has become the most broadly used and powerful tool for genome editing. Many applications of CRISPR-Cas9 require the delivery of multiple small guide ...
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20 Protocols edited
Notch Ligand Binding Assay Using Flow Cytometry
Authors:  Shweta Varshney and Pamela Stanley, date: 12/05/2017, view: 138, Q&A: 0
Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013). The ...
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RNA Extraction from Wistar Rat Cochlea for qRT-PCR
Authors:  Janaína Cândida Rodrigues and Rubens Vuono de Brito Neto, date: 12/05/2017, view: 76, Q&A: 0
Otology research has developed considerably in recent years and molecular analysis is crucial to identify metabolic pathways and therapeutic targets. However, the structure of the cochlea limits the amount of cell mass, and special care is required ...
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