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Coauthors
Johan Neyts KU Leuven – University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Belgium
3 protocols

Kai Dallmeier Microbiology and Immunology Department, University of Leuven, Belgium
2 protocols
Coreviewers
Anca Savulescu The Council for Scientific and Industrial Research
3 protocols

Angela Corona University of Cagliari
3 protocols

Balasubramanian Venkatakrishnan Syngene International Limited
2 protocols

Chang Ho Lee Dankook University
4 protocols

Editor
Yannick Debing
  • Janssen Pharmaceutica
Research focus
  • Microbiology
  • 2 Author merit

Education

Ph.D. in Virology, Rega Institute, University of Leuven, Belgium, 2015

Current position

Postdoctoral fellow, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands
Research interests: Hepatitis E virus, antiviral therapy, viral myocarditis

Publications

  1. Dao Thi, V. L., Debing, Y., Wu, X., Rice, C. M., Neyts, J., Moradpour, D. and Gouttenoire, J. (2015). Sofosbuvir inhibits Hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin. Gastroenterology. (Epub ahead of print)
  2. Debing, Y., Emerson, S. U., Purcell, R. H., Neyts, J. and Dallmeier, K. (2014). Complete genome sequence of a rat hepatitis e virus strain isolated in the United States. Genome Announc 2(6).
  3. Debing, Y., Gisa, A., Dallmeier, K., Pischke, S., Bremer, B., Manns, M., Wedemeyer, H., Suneetha, P. V. and Neyts, J. (2014). A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients. Gastroenterology 147(5): 1008-1011 e1007; quiz e1015-1006. 
  4. Debing, Y. and Neyts, J. (2014). mTOR-inhibitors may aggravate chronic hepatitis E. J Hepatol 61(4): 720-722.        
  5. Wang, Y., Zhou, X., Debing, Y., Chen, K., Van Der Laan, L. J., Neyts, J., Janssen, H. L., Metselaar, H. J., Peppelenbosch, M. P. and Pan, Q. (2014). Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. Gastroenterology 146(7): 1775-1783.
  6. Debing, Y. and Neyts, J. (2014). Antiviral strategies for hepatitis E virus. Antiviral Res 102: 106-118.
  7. Debing, Y., Emerson, S. U., Wang, Y., Pan, Q., Balzarini, J., Dallmeier, K. and Neyts, J. (2014). Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon. Antimicrob Agents Chemother 58(1): 267-273.
  8. Rocha-Pereira, J., Jochmans, D., Debing, Y., Verbeken, E., Nascimento, M. S. and Neyts, J. (2013). The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model. J Virol 87(21): 11798-11805.
  9. Debing, Y., Winton, J., Neyts, J. and Dallmeier, K. (2013). Cutthroat trout virus as a surrogate in vitro infection model for testing inhibitors of hepatitis E virus replication. Antiviral Res 100(1): 98-101.
  10. Debing, Y., Neyts, J. and Thibaut, H. J. (2013). Molecular Biology and Inhibitors of Hepatitis A Virus. Med Res Rev.
  11. Chatelain, G., Debing, Y., De Burghgraeve, T., Zmurko, J., Saudi, M., Rozenski, J., Neyts, J. and Van Aerschot, A. (2013). In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues. Eur J Med Chem 65: 249-255.
  12. Debing, Y., Jochmans, D. and Neyts, J. (2013). Intervention strategies for emerging viruses: use of antivirals. Curr Opin Virol 3(2): 217-224.
  13. Debing, Y., Kaplan, G. G., Neyts, J. and Jochmans, D. (2013). Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication. Antiviral Res 98(2): 325-331.
  14. De Burghgraeve, T., Selisko, B., Kaptein, S., Chatelain, G., Leyssen, P., Debing, Y., Jacobs, M., Van Aerschot, A., Canard, B. and Neyts, J. (2013). 3',5'Di-O-trityluridine inhibits in vitro flavivirus replication. Antiviral Res 98(2): 242-247.
2 Protocols published
Luminescence-based Antiviral Assay for Hepatitis E Virus
Authors:  Yannick Debing, Kai Dallmeier and Johan Neyts, date: 08/05/2014, view: 3529, Q&A: 0
Hepatitis E virus (HEV) is one of the main causes of acute hepatitis worldwide. Infections are particularly severe in pregnant women and chronic hepatitis E is known to occur in immunocompromised patients. Current therapy (ribavirin or pegylated ...
Infectious Virus Yield Assay for Hepatitis E Virus
Authors:  Yannick Debing, Kai Dallmeier and Johan Neyts, date: 08/05/2014, view: 4114, Q&A: 0
Hepatitis E virus (HEV) is one of the main causes of acute hepatitis worldwide. Infections are particularly severe in pregnant women and chronic hepatitis E is known to occur in immunocompromised patients. Current therapy (ribavirin or pegylated ...
3 Protocols reviewed
Measurement of 2-methylthio Modifications in Mitochondrial Transfer RNAs by Reverse-transcription Quantitative PCR
Authors:  Fan-Yan Wei and Kazuhito Tomizawa, date: 01/05/2016, view: 2220, Q&A: 0
2-Methylthio-N6-isopentenyladenosine (ms2i6A) is an evolutionally conserved posttranscriptional modification found at position 37 of four mammalian mitochondrial tRNAs, mt-tRNASer(UCN), mt-tRNATrp ...
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Introduction and Sequencing of Patient-isolated HBV RT Sequences into the HBV 1.2-mer Replicon
Authors:  Sung Hyun Ahn, Yong Kwang Park and Kyun-Hwan Kim, date: 04/20/2015, view: 2738, Q&A: 0
Antiviral agents for the suppression of hepatitis B virus (HBV) have been used for treating chronic hepatitis B. However, the emergence of drug-resistant HBV is still a major problem for antiviral treatment. To identify and characterize the ...
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18 Protocols edited
Establishment of a Human Cell Line Persistently Infected with Sendai Virus
Authors:  Christopher Coakley, Cara Peter, Stephanie Fabry and Saurabh Chattopadhyay, date: 08/20/2017, view: 877, Q&A: 0
Interferon regulatory transcription factor 3 (IRF3) is a transcription factor that upon activation by virus infection promotes the synthesis of antiviral genes, such as the interferons (Hiscott, 2007). In addition to inducing genes, IRF3 triggers ...
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Ultradeep Pyrosequencing of Hepatitis C Virus to Define Evolutionary Phenotypes
Analysis of hypervariable regions (HVR) using pyrosequencing techniques is hampered by the ability of error correction algorithms to account for the heterogeneity of the variants present. Analysis of between-sample fluctuations to virome ...
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