Melissa Caimano Departments of Medicine, University of Connecticut Health Center, USA
1 protocol

Jarlath Nally Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, USA
1 protocol

Alan McBride Unidade de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Brasil
1 protocol

André Alex Grassmann
  • Unidade de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Brasil
Research focus
  • Molecular biology
  • 1 Author merit
  • 1 Reviewer merit


Ph.D. in Biotechnology, Federal University of Pelotas - UFPel, Brazil, 2015

Current position

Postdoctoral Researcher, Federal University of Pelotas - UFPel, Brazil


  1. Caimano, M. J., Sivasankaran, S. K., Allard, A., Hurley, D., Hokamp, K., Grassmann, A. A., Hinton, J. C. and Nally, J. E. (2014). A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni. PLoS Pathog 10(3): e1004004.
  2. Grassmann, A. A., Felix, S. R., dos Santos, C. X., Amaral, M. G., SeixasNeto, A. C., Fagundes, M. Q., Seixas, F. K., da Silva, E. F., Conceicao, F. R. and Dellagostin, O. A. (2012). Protection against lethal leptospirosis after vaccination with LipL32 coupled or coadministered with the B subunit of Escherichia coli heat-labile enterotoxin. Clin Vaccine Immunol 19(5): 740-745.
  3. Diniz, J. A., Felix, S. R., Bonel-Raposo, J., SeixasNeto, A. C., Vasconcellos, F. A., Grassmann, A. A., Dellagostin, O. A., Aleixo, J. A. and da Silva, E. F. (2011). Highly virulent Leptospira borgpetersenii strain characterized in the hamster model. Am J Trop Med Hyg 85(2): 271-274.
  4. Dellagostin, O. A., Grassmann, A. A., Hartwig, D. D., Felix, S. R., da Silva, E. F. and McBride, A. J. (2011). Recombinant vaccines against leptospirosis. Hum Vaccin 7(11): 1215-1224.
  5. da Silva, E. F., Felix, S. R., Cerqueira, G. M., Fagundes, M. Q., Neto, A. C., Grassmann, A. A., Amaral, M. G., Gallina, T. and Dellagostin, O. A. (2010). Preliminary characterization of Mus musculus-derived pathogenic strains of Leptospira borgpetersenii serogroup Ballum in a hamster model. Am J Trop Med Hyg 83(2): 336-337.
  6. Felix, S.R., Silva, É.F.,Jouglard, S.D.D., Hartmann, D.M.,Grassmann, A.A. andDellagostin, O.A.(2009).Leptospirosis vaccine: search for subunit candidates. Procedia Vaccinology 1: 110-114.
  7. da Silva Ramos Rocha, A., Conceicao, F. R., Grassmann, A. A., Lagranha, V. L. and Dellagostin, O. A. (2008). B subunit of Escherichia coli heat-labile enterotoxin as adjuvant of humoral immune response in recombinant BCG vaccination. Can J Microbiol 54(8): 677-686.
1 Protocol published
Generation of Mammalian Host-adapted Leptospira interrogans by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats
Leptospira interrogans can infect a myriad of mammalian hosts, including humans (Bharti et al., 2003; Ko et al., 2009). Following acquisition by a suitable host, leptospires disseminate via the bloodstream to ...