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Fanglian He University of Pennsylvania
205 protocols

Jyotiska Chaudhuri Buck Institute for Research on Aging
17 protocols

Kristin Shingler University of Minnesota School of Dentistry
5 protocols

Michael Enos Stanford University
12 protocols

Editor
Peichuan Zhang
  • Research scientist, Calico Life Sciences
Research focus
  • Molecular biology
  • Aging, genetics, C. elegans
  • 5 Author merit

Education

PhD, Pennsylvania State University, 2003

Lab information

Cynthia Kenyon

Publications

1) Mack, H.I.D., Zhang, P., Fonslow, B.R., and Yates, J.R. The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans. Aging (Albany NY). 2017. [Epub ahead of print]

2) Zhang, P., Judy, M., Lee, S.J., and Kenyon, C. Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metabolism. 2013. 17:85-100.

3) Henis-Korenblit, S., Zhang, P., Hansen, M., McCormick, M., Lee, S.J., Cary, M., and Kenyon, C. Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 2010. 107:9730-5.

4) Yamawaki, T.M., Arantes-Oliveira, N., Berman, J.R., Zhang, P., and Kenyon, C. Independent activities of the germline and somatic reproductive tissues in the regulation of C. elegans’ lifespan. Genetics. 2008. 178:513-26.

5 Protocols published
Analysis of Mouse Liver Glycogen Content
Author:  Peichuan Zhang, date: 05/20/2012, view: 22394, Q&A: 10
Liver is the major site for glycogen storage. Glycogen content can be significantly altered upon disruption of glucose homeostasis in metabolic syndromes, such as diabetes. Glycogen content can be determined by an acid-hydrolysis method ...
Alcian Blue – Alizarin Red Staining of Mouse Skeleton
Author:  Peichuan Zhang, date: 04/20/2012, view: 17978, Q&A: 8
Our lab has used the Alcian blue – Alizarin red staining method with certain modifications to characterize skeleton deformities in mice lacking Pek/Perk, encoding a translational control eIF2alpha kinase.
2 Protocols reviewed
Chemotaxis and Jumping Assays in Nematodes
Authors:  Tiffany Baiocchi and Adler R. Dillman, date: 09/20/2015, view: 2766, Q&A: 0
Nematodes have sensitive olfactory perception, which is used to detect and differentiate many volatile odorants. Some odorants are attractive, others repulsive, and yet others evoke no particular response. Chemotaxis assays can be used to determine ...
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Lipid Extraction from Mouse Feces
Authors:  Daniel Kraus, Qin Yang and Barbara B. Kahn, date: 01/05/2015, view: 6581, Q&A: 0
The analysis of feces composition is important for the study of energy metabolism, which comprises various measurements of energy intake, energy expenditure, and energy wasting. The current protocol describes how to measure energy-dense lipids in ...
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12 Protocols edited
Infection of Caenorhabditis elegans with Vesicular Stomatitis Virus via Microinjection
Authors:  Adam Martin, Emily A. Rex, Takao Ishidate, Rueyling Lin and Don B. Gammon, date: 11/20/2017, view: 68, Q&A: 0
Over the past 15 years, the free-living nematode, Caenorhabditis elegans has become an important model system for exploring eukaryotic innate immunity to bacterial and fungal pathogens. More recently, infection models using either natural ...
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Superoxide Dismutase (SOD) and Catalase (CAT) Activity Assay Protocols for Caenorhabditis elegans
Authors:  Jing Zhang, Rui Chen, Zhenyang Yu and Lili Xue, date: 08/20/2017, view: 867, Q&A: 0
Assays for superoxide dismutase (SOD) and catalase (CAT) activities are widely employed to indicate antioxidant responses underlying the toxic effects of test chemicals. Yet, earlier studies mainly described the procedures as performed according to ...
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