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Coauthors
David Cole 1 protocol

Andrew Sewell 1 protocol

Alexei Zhurov Cardiff University School of Dentistry, UK
1 protocol

Angharad Lloyd Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University School of Medicine, UK
1 protocol

Konrad Beck
  • Cardiff University School of Dentistry, UK
Contributions
  • 1 Author merit

Education

Ph.D in Biophysics, Max Planck Institute of Biophysics, Department of Cell Physiology, Frankfurt am Main, Germany, 1984

Current position

Lecturer in Protein Biophysics, Cardiff University, College of Biomedical and Life Sciences

Publications (since 2010)

  1. Pritchard, M. F., Powell, L. C., Khan, S., Griffiths, P. C., Mansour, O. T., Schweins, R., Beck, K., Buurma, N. J., Dempsey, C. E., Wright, C. J., Rye, P. D., Hill, K. E., Thomas, D. W. and Ferguson, E. L. (2017). The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Sci Rep 7: 44731.
  2. Nomikos, M., Stamatiadis, P., Sanders, J. R., Beck, K., Calver, B. L., Buntwal, L., Lofty, M., Sideratou, Z., Swann, K. and Lai, F. A. (2017). Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCzeta. Biochem J 474(6): 1003-1016.
  3. Cole, D. K., van den Berg, H. A., Lloyd, A., Crowther, M. D., Beck, K., Ekeruche-Makinde, J., Miles, J. J., Bulek, A. M., Dolton, G., Schauenburg, A. J., Wall, A., Fuller, A., Clement, M., Laugel, B., Rizkallah, P. J., Wooldridge, L. and Sewell, A. K. (2017). Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase. J Biol Chem 292(3): 802-813.
  4. Nomikos, M., Thanassoulas, A., Beck, K., Theodoridou, M., Kew, J., Kashir, J., Calver, B. L., Matthews, E., Rizkallah, P., Sideratou, Z., Nounesis, G. and Lai, F. A. (2016). Mutations in PLCdelta1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function. FEBS J 283(24): 4502-4514.
  5. Ulaeto, D. O., Morris, C. J., Fox, M. A., Gumbleton, M. and Beck, K. (2016). Destabilization of alpha-Helical Structure in Solution Improves Bactericidal Activity of Antimicrobial Peptides: Opposite Effects on Bacterial and Viral Targets. Antimicrob Agents Chemother 60(4): 1984-1991.
  6. Roberts, J. L., Cattoz, B., Schweins, R., Beck, K., Thomas, D. W., Griffiths, P. C. and Ferguson, E. L. (2016). In Vitro Evaluation of the Interaction of Dextrin-Colistin Conjugates with Bacterial Lipopolysaccharide. J Med Chem 59(2): 647-654.
  7. Jones, K., Wockner, L., Brennan, R. M., Keane, C., Chattopadhyay, P. K., Roederer, M., Price, D. A., Cole, D. K., Hassan, B., Beck, K., Gottlieb, D., Ritchie, D. S., Seymour, J. F., Vari, F., Crooks, P., Burrows, S. R. and Gandhi, M. K. (2016). The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma. Clin Exp Immunol 183(2): 206-220.
  8. Kloverpris, H. N., Cole, D. K., Fuller, A., Carlson, J., Beck, K., Schauenburg, A. J., Rizkallah, P. J., Buus, S., Sewell, A. K. and Goulder, P. (2015). A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12: 20.
  9. Vassilakopoulou, V., Calver, B. L., Thanassoulas, A., Beck, K., Hu, H., Buntwal, L., Smith, A., Theodoridou, M., Kashir, J., Blayney, L., Livaniou, E., Nounesis, G., Lai, F. A. and Nomikos, M. (2015). Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease. Biochim Biophys Acta 1850(11): 2168-2176.
  10. Motozono, C., Pearson, J. A., De Leenheer, E., Rizkallah, P. J., Beck, K., Trimby, A., Sewell, A. K., Wong, F. S. and Cole, D. K. (2015). Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide. J Biol Chem 290(31): 18924-18933.
  11. Knight, R. R., Dolton, G., Kronenberg-Versteeg, D., Eichmann, M., Zhao, M., Huang, G. C., Beck, K., Cole, D. K., Sewell, A. K., Skowera, A. and Peakman, M. (2015). A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clin Exp Immunol 179(1): 100-107.
  12. Borko, L., Bauerova-Hlinkova, V., Hostinova, E., Gasperik, J., Beck, K., Lai, F. A., Zahradnikova, A. and Sevcik, J. (2014). Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias. Acta Crystallogr D Biol Crystallogr 70(Pt 11): 2897-2912.
  13. Nomikos, M., Thanassoulas, A., Beck, K., Vassilakopoulou, V., Hu, H., Calver, B. L., Theodoridou, M., Kashir, J., Blayney, L., Livaniou, E., Rizkallah, P., Nounesis, G. and Lai, F. A. (2014). Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death. FEBS Lett 588(17): 2898-2902.
  14. Blayney, L., Beck, K., MacDonald, E., D'Cruz, L., Nomikos, M., Griffiths, J., Thanassoulas, A., Nounesis, G. and Lai, F. A. (2013). ATP interacts with the CPVT mutation-associated central domain of the cardiac ryanodine receptor. Biochim Biophys Acta 1830(10): 4426-4432.
  15. Thomas, H., Beck, K., Adamczyk, M., Aeschlimann, P., Langley, M., Oita, R. C., Thiebach, L., Hils, M. and Aeschlimann, D. (2013). Transglutaminase 6: a protein associated with central nervous system development and motor function. Amino Acids 44(1): 161-177.
  16. Rousselle, P. and Beck, K. (2013). Laminin 332 processing impacts cellular behavior. Cell Adh Migr 7(1): 122-134.
  17. Morris, C. J., Beck, K., Fox, M. A., Ulaeto, D., Clark, G. C. and Gumbleton, M. (2012). Pegylation of antimicrobial peptides maintains the active peptide conformation, model membrane interactions, and antimicrobial activity while improving lung tissue biocompatibility following airway delivery. Antimicrob Agents Chemother 56(6): 3298-3308.
  18. Carulli, S., Beck, K., Dayan, G., Boulesteix, S., Lortat-Jacob, H. and Rousselle, P. (2012). Cell surface proteoglycans syndecan-1 and -4 bind overlapping but distinct sites in laminin alpha3 LG45 protein domain. J Biol Chem 287(15): 12204-12216.
  19. Bauerová-Hlinková, V., Bauer, J., Hostinová, E., Gašperík, J., Beck, K., Borko, L., Faltínová, A., Zahradníková, A. and Ševčík, J. (2011). Bioinformatics Domain Structure Prediction and Homology Modeling of Human Ryanodine Receptor 2. Bioinformatics - Trends and Methodologies.
  20. Deacon, S. P., Apostolovic, B., Carbajo, R. J., Schott, A. K., Beck, K., Vicent, M. J., Pineda-Lucena, A., Klok, H. A. and Duncan, R. (2011). Polymer coiled-coil conjugates: potential for development as a new class of therapeutic "molecular switch". Biomacromolecules 12(1): 19-27.
  21. Bauerova-Hlinkova, V., Hostinova, E., Gasperik, J., Beck, K., Borko, L., Lai, F. A., Zahradnikova, A. and Sevcik, J. (2010). Bioinformatic mapping and production of recombinant N-terminal domains of human cardiac ryanodine receptor 2. Protein Expr Purif 71(1): 33-41.
1 Protocol published
Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy
T cell receptor (TCR) recognition of foreign peptide fragments, presented by peptide major histocompatibility complex (pMHC), governs T-cell mediated protection against pathogens and cancer. Many factors govern T-cell sensitivity, including the ...