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Coauthors
Remco Megens Institute for Cardiovascular Prevention (IPEK), Klinikum der Universität München, Ludwig-Maximilians-University, Germany
1 protocol

Christian Weber Institute for Cardiovascular Prevention, Germany
3 protocols

Yvonne Döring Institute for Cardiovascular Prevention (IPEK), Klinikum der Universität München, Ludwig-Maximilians-University, Germany
1 protocol

Oliver Soehnlein Institute for Cardiovascular Prevention (IPEK), Klinikum der Universität München, Ludwig-Maximilians-University, Germany
1 protocol

Reviewer
Emiel van der Vorst
  • Ludwig Maximilians University
Research focus
  • Immunology
  • 1 Author merit

Education

Ph.D in Vascular Inflammation, Maastricht University, The Netherlands, 2010

Current position

Postdoctoral Research Fellow, Institute for Cardiovascular Prevention , Ludwig-Maximilians-University, Germany

Publications

  1. Doring, Y., Noels, H., van der Vorst, E. P. C., Neideck, C., Egea, V., Drechsler, M., Mandl, M., Pawig, L. B., Jansen, Y., Schroder, K., Bidzhekov, K., Megens, R. T. A., Theelen, W., Klinkhammer, B. M., Boor, P., Schurgers, L. J., van Gorp, R. H., Ries, C., Kusters, P. J. H., van der Wal, A. C., Hackeng, T. M., Gabel, G., Brandes, R. P., Soehnlein, O., Lutgens, E., Vestweber, D., Teupser, D., Holdt, L. M., Rader, D. J., Saleheen, D. and Weber, C. (2017). Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence from Mouse and Human Studies. Circulation.
  2. van der Vorst, E. P. C., Theodorou, K., Biessen, E. A. L. and Donners, M. (2017). HDL and macrophages: explaining the clinical failures and advancing HDL-based therapeutics in cardiovascular diseases? Expert Rev Cardiovasc Ther 15(5): 343-344.
  3. Rinne, P., Rami, M., Nuutinen, S. L., Santovito, D., van der Vorst, E. P. C., Guillamat-Prats, R., Lyytikainen, L. P., Raitoharju, E., Oksala, N., Ring, L., Cai, M., Hruby, V. J., Lehtimaki, T. J., Weber, C. and Steffens, S. (2017). Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation.
  4. Rademakers, T., van der Vorst, E. P., Daissormont, I. T., Otten, J. J., Theodorou, K., Theelen, T. L., Gijbels, M., Anisimov, A., Nurmi, H., Lindeman, J. H., Schober, A., Heeneman, S., Alitalo, K. and Biessen, E. A. (2017). Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Sci Rep 7: 45263.
  5. Weber, C., Badimon, L., Mach, F. and van der Vorst, E. P. C. (2017). Therapeutic strategies for atherosclerosis and atherothrombosis: Past, present and future. Thromb Haemost 117(7): 1258-1264.
  6. van der Vorst, E. P., Zhao, Z., Rami, M., Holdt, L. M., Teupser, D., Steffens, S. and Weber, C. (2017). Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development. Thromb Haemost 117(3): 644-646.
  7. van der Vorst, E. P., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., Aliyev, T., Huitema, L. F., Tas, S. W., Wolfs, I. M., Kuijpers, M. J., Gijbels, M. J., Schalkwijk, C. G., Koonen, D. P., Abdollahi-Roodsaz, S., McDaniels, K., Wang, C. C., Leitges, M., Lawrence, T., Plat, J., Van Eck, M., Rye, K. A., Touqui, L., de Winther, M. P., Biessen, E. A. and Donners, M. M. (2017). High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappaB/STAT1-IRF1 Signaling. Cell Metab 25(1): 197-207.
  8. Hyafil, F., Pelisek, J., Laitinen, I., Schottelius, M., Mohring, M., Doring, Y., van der Vorst, E. P., Kallmayer, M., Steiger, K., Poschenrieder, A., Notni, J., Fischer, J., Baumgartner, C., Rischpler, C., Nekolla, S. G., Weber, C., Eckstein, H. H., Wester, H. J. and Schwaiger, M. (2017). Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer 68Ga-Pentixafor for PET. J Nucl Med 58(3): 499-506.
  9. Chubanov, V., Ferioli, S., Wisnowsky, A., Simmons, D. G., Leitzinger, C., Einer, C., Jonas, W., Shymkiv, Y., Bartsch, H., Braun, A., Akdogan, B., Mittermeier, L., Sytik, L., Torben, F., Jurinovic, V., van der Vorst, E. P., Weber, C., Yildirim, O. A., Sotlar, K., Schurmann, A., Zierler, S., Zischka, H., Ryazanov, A. G. and Gudermann, T. (2016). Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5.
  10. Van der Vorst, E. P., Döring, Y. and Weber, C. (2015). Chemokines and their receptors in Atherosclerosis. J Mol Med 93(9): 963-71.
  11. van der Vorst, E. P., Doring, Y. and Weber, C. (2015). MIF and CXCL12 in Cardiovascular Diseases: Functional Differences and Similarities. Front Immunol 6: 373.
  12. Kusters, D. H., Chatrou, M. L., Willems, B. A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E. A., Perretti, M., Schurgers, L. J. and Reutelingsperger, C. P. (2015). Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. PLoS One 10(6): e0130484.
  13. van der Vorst, E. P., Jeurissen, M., Wolfs, I. M., Keijbeck, A., Theodorou, K., Wijnands, E., Schurgers, L., Weber, S., Gijbels, M. J., Hamers, A. A., Dreymueller, D., Rose-John, S., de Winther, M. P., Ludwig, A., Saftig, P., Biessen, E. A. and Donners, M. M. (2015). Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis. Am J Pathol 185(4): 1145-1155.
  14. Van der Vorst, E. P., Döring, Y. and Weber, C. (2015). Recent Highlights of ATVB: Chemokines. ATVB 35(11): 52-6.
  15. Burgmaier, M., Schutters, K., Willems, B., van der Vorst, E. P., Kusters, D., Chatrou, M., Norling, L., Biessen, E. A., Cleutjens, J., Perretti, M., Schurgers, L. J. and Reutelingsperger, C. P. (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. J Cell Mol Med 18(10): 2117-2124.
  16. Pruessmeyer, J., Hess, F. M., Ahlert, H., Groth, E., Pasqualon, T., Schwarz, N., Nyamoya, S., Kollert, J., Van der Vorst, E. P., Donners, M. M., Martin, C., Uhlig, S., Saftig, P., Dreymueller, D. and Ludwig, A. (2014). Leukocytes require the metalloproteinase ADAM10 but not ADAM17 for efficient cell migration and for inflammatory leukocyte recruitment into the alveolar space. Blood 123(26): 4077-88.
  17. Wolfs, I. M., Stoger, J. L., Goossens, P., Pottgens, C., Gijbels, M. J., Wijnands, E., van der Vorst, E. P., van Gorp, P., Beckers, L., Engel, D., Biessen, E. A., Kraal, G., van Die, I., Donners, M. M. and de Winther, M. P. (2014). Reprogramming macrophages to an anti-inflammatory phenotype by helminth antigens reduces murine atherosclerosis. FASEB J 28(1): 288-299.
  18. van der Vorst, E. P., Vanags, L. Z., Dunn, L. L., Prosser, H. C., Rye, K. A. and Bursill, C. A. (2013). High-density lipoproteins suppress chemokine expression and proliferation in human vascular smooth muscle cells. FASEB J 27(4): 1413-1425.
  19. van der Vorst, E. P., Keijbeck, A. A., de Winther, M. P. and Donners, M. M. (2012). A disintegrin and metalloproteases: molecular scissors in angiogenesis, inflammation and atherosclerosis. Atherosclerosis 224(2): 302-308.
  20. Donners, M. M., Wolfs, I. M., Stoger, L. J., van der Vorst, E. P., Pottgens, C. C., Heymans, S., Schroen, B., Gijbels, M. J. and de Winther, M. P. (2012). Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice. PLoS One 7(4): e35877.
  21. Bursill, C. A., Castro, M. L., Beattie, D. T., Nakhla, S., van der Vorst, E., Heather, A. K., Barter, P. J. and Rye, K. A. (2010). High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo. Arterioscler Thromb Vasc Biol 30(9): 1773-1778.
1 Protocol published
Functional ex-vivo Imaging of Arterial Cellular Recruitment and Lipid Extravasation
The main purpose of this sophisticated and highly versatile method is to visualize and quantify structural vessel wall properties, cellular recruitment, and lipid/dextran extravasation under physiological conditions in living arteries. This will be ...