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Coauthors
Marie-Cécile Didiot University of Massachusetts Medical School, United States
2 protocols

Anastasia Khvorova RNA Therapeutics Institute, University of Massachusetts Medical School, USA
2 protocols

Lauren Hall RNA Therapeutics Institute, University of Massachusetts Medical School, USA
1 protocol

Andrew Coles RNA Therapeutics Institute, University of Massachusetts Medical School, USA
2 protocols

Neil Aronin
  • RNA Therapeutics Institute, University of Massachusetts Medical School, USA
Contributions
  • 2 Author merit
2 Protocols published
A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics
Primary neurons represent an ideal cellular system for the identification of therapeutic oligonucleotides for the treatment of neurodegenerative diseases. However, due to the sensitive nature of primary cells, the transfection of small interfering ...
Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System
Authors:  Reka A. Haraszti, Andrew Coles, Neil Aronin, Anastasia Khvorova and Marie-Cécile Didiot, date: 06/20/2017, view: 1155, Q&A: 0
Efficient delivery of oligonucleotide therapeutics, i.e., siRNAs, to the central nervous system represents a significant barrier to their clinical advancement for the treatment of neurological disorders. Small, endogenous extracellular ...