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Coauthors
Jennifer Jane McGhee Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, the University of Auckland, New Zealand
1 protocol

Salim Ismail Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, the University of Auckland, New Zealand
1 protocol

Jeremy John Mathan Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, the University of Auckland, New Zealand
1 protocol

Trevor Sherwin
  • Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, the University of Auckland, New Zealand
Contributions
  • 1 Author merit

Education

Ph.D, Cell Biology, University of Kent, 1989

Current position

Professor of Ophthalmology and Visual Sciences, University of Auckland, New Zealand
Associate Dean Postgraduate - FMHS

Publications

  1. Sherwin, T., Ismail, S., Loh, I-P. and McGhee, J. J. (2017). Histopathology (from Keratoconus Pathology to Pathogenesis). In: Alio, J. (Ed). Keratoconus: Recent Advances in Diagnosis and Treatment. Springer.
  2. Kim, B. Z., Meyer, J. J., Brookes, N. H., Moffatt, S. L., Twohill, H. C., Pendergrast, D. G., Sherwin, T. and McGhee, C. N. J. (2017). New Zealand trends in corneal transplantation over the 25 years 1991-2015. Br J Ophthalmol 101(6): 834-838.
  3. Naylor, R. W., McGhee, C. N., Cowan, C. A., Davidson, A. J., Holm, T. M. and Sherwin, T. (2016). Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells. PLoS One 11(10): e0165464.
  4. Mathan, J. J., Ismail, S., McGhee, J. J., McGhee, C. N. and Sherwin, T. (2016). Sphere-forming cells from peripheral cornea demonstrate the ability to repopulate the ocular surface. Stem Cell Res Ther 7(1): 81.
  5. Greene, C. A., Green, C. R., Dickinson, M. E., Johnson, V. and Sherwin, T. (2016). Keratocytes are induced to produce collagen type II: A new strategy for in vivo corneal matrix regeneration. Exp Cell Res 347(1): 241-249.
  6. Wilson, P. J., Mathan, J. J., Ismail, S., McGhee, J. J., Sherwin, T. and Mcghee, C. N. J. (2016). Autologous Corneal Repair Using In-Vitro Adult Stem Cell Expansion. J. Stem Cell & Regenerative Biology 2: 1-7.
  7. Oliver, V. F., van Bysterveldt, K. A., Cadzow, M., Steger, B., Romano, V., Markie, D., Hewitt, A. W., Mackey, D. A., Willoughby, C. E., Sherwin, T., Crosier, P. S., McGhee, C. N. and Vincent, A. L. (2016). A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. Ophthalmology 123: 709-722.
  8. Fan Gaskin, J. C., Loh, I-P, McGhee, C. N. J. and Sherwin, T. (2015). An Immuno-histochemical Study of Inflammatory Cell Changes and Matrix Remodeling With and Without Acute Hydrops in Keratoconus. Investigative Opthalmology & Visual Science 56: 5831-5831.
  9. Wilson, P. J. and Sherwin, T. (2015). Amniotic amulet. Clin Exp Ophthalmol 43(5): 403-404.
  10. Huang, S. U., Yoon, J. J., Ismail, S., McGhee, J. J. and Sherwin, T. (2015). Sphere-forming cells from peripheral cornea demonstrate a wound-healing response to injury. Cell Biol Int 39(11): 1274-1287.
  11. Galvis, V., Sherwin, T., Tello, A., Merayo, J., Barrera, R. and Acera, A. (2015). Keratoconus: an inflammatory disorder? Eye (Lond) 29(7): 843-859.
  12. Greene, C. A., Green, C. R. and Sherwin, T. (2015). Transdifferentiation of chondrocytes into neuron-like cells induced by neuronal lineage specifying growth factors. Cell Biol Int 39(2): 185-191.
  13. Cheung, I. M., McGhee, C. N. and Sherwin, T. (2014). Beneficial effect of the antioxidant riboflavin on gene expression of extracellular matrix elements, antioxidants and oxidases in keratoconic stromal cells. Clin Exp Optom 97(4): 349-355.
  14. Yoon, J. J., Ismail, S. and Sherwin, T. (2014). Limbal stem cells: Central concepts of corneal epithelial homeostasis. World J Stem Cells 6(4): 391-403.
  15. Greene, C. A., Chang, C. Y., Fraser, C. J., Nelidova, D. E., Chen, J. A., Lim, A., Brebner, A., McGhee, J., Sherwin, T. and Green, C. R. (2014). Cells from the adult corneal stroma can be reprogrammed to a neuron-like cell using exogenous growth factors. Exp Cell Res 322(1): 122-132.
  16. Cheung, I. M., McGhee, C. and Sherwin, T. (2014). Deficient repair regulatory response to injury in keratoconic stromal cells. Clin Exp Optom 97(3): 234-239.
  17. Yoon, J. J., Wang, E. F., Ismail, S., McGhee, J. J. and Sherwin, T. (2013). Sphere-forming cells from peripheral cornea demonstrate polarity and directed cell migration. Cell Biol Int 37(9): 949-960.
  18. Cheung, I. M., McGhee, C. N. and Sherwin, T. (2013). A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species-associated processes. Clin Exp Optom 96(2): 188-196.
  19. Patel, D. V., McKelvie, J., Sherwin, T. and McGhee, C. (2013). Keratocyte progenitor cell transplantation: A novel therapeutic strategy for corneal disease. Med Hypotheses 80(2): 122-124.
  20. Cheung, I., McGhee, C. N. J. and Sherwin, T. (2012). Are defects in wound healing and reactive oxygen species-associated pathways implicated in the pathobiology of keratoconus? Clinical and Experimental Ophthalmology 40: 32-33.
  21. Ormonde, S., Chou, C. Y., Goold, L., Petsoglou, C., Al-Taie, R., Sherwin, T., McGhee, C. N. and Green, C. R. (2012). Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds. J Membr Biol 245(7): 381-388.
  22. Nelidova, D. and Sherwin, T. (2012). The matrix metalloproteinase hypothesis of keratoconus: layer by layer. In: ADVANCES IN OPHTHALMOLOGY, InTech.
  23. Chang, C. Y., McGhee, J. J., Green, C. R. and Sherwin, T. (2011). Comparison of stem cell properties in cell populations isolated from human central and limbal corneal epithelium. Cornea 30(10): 1155-1162.
  24. Vincent, A. L. and Sherwin, T. (2010). Utility and efficacy of TGFBI mutational analysis for disease detection. Expert Rev Mol Diagn 10(5): 569-573.
  25. Sherwin, T. and McGhee, C. N. (2010). Corneal epithelial homeostasis. Ophthalmology 117(1): 190-191; author reply 191-192.
  26. Sherwin, T. (2009). A new niche for the corneal epithelial stem cell. Clin Exp Ophthalmol 37(7): 644-645.
  27. Chang, C. Y., Laux-Fenton, W. T., Law, L. Y., Becker, D. L., Sherwin, T. and Green, C. R. (2009). Antisense down regulation of connexin31.1 reduces apoptosis and increases thickness of human and animal corneal epithelia. Cell Biol Int 33(3): 376-385.
  28. Brookes, N. H., Niederer, R. L., Hickey, D., McGhee, C. N. and Sherwin, T. (2009). Recurrence of keratoconic pathology in penetrating keratoplasty buttons originally transplanted for keratoconus. Cornea 28(6): 688-693.
  29. Sherwin, T., Cartwright, V. A. and Foggin, S. (2009). Finding Information in Medical Sciences. In: Gupta, Y. K., Jagadeesh, G. and Prakash, A. (Eds). from getting started in research to presenting data in a scientific paper.
  30. Chang, C. Y., Green, C. R., McGhee, C. N. J. and Sherwin, T. (2008). Corneal central epithelial wound healing occurs independently of the limbus. Investigative Ophthalmology and Visual Science 49: 5279-86.
  31. Wheeldon, C. E., de Karolyi, B. H., Patel, D. V., Sherwin, T., McGhee, C. N. and Vincent, A. L. (2008). A novel phenotype-genotype relationship with a TGFBI exon 14 mutation in a pedigree with a unique corneal dystrophy of Bowman's layer. Mol Vis 14: 1503-1512.
  32. Niederer, R. L., Johnson, R. A., Patel, D. V., Sherwin, T. and McGhee, C. N. J. (2008). Quantitative comparison of slit scanning and laser scanning in vivo confocal microscopy for evaluation of normal human corneal architecture. Ophthalmology.
  33. Niederer, R. L., Perumal, D., Sherwin, T. and McGhee, C. N. (2008). Laser scanning in vivo confocal microscopy reveals reduced innervation and reduction in cell density in all layers of the keratoconic cornea. Invest Ophthalmol Vis Sci 49(7): 2964-2970.
  34. Ku, J. Y., Niederer, R. L., Patel, D. V., Sherwin, T. and McGhee, C. N. (2008). Laser scanning in vivo confocal analysis of keratocyte density in keratoconus. Ophthalmology 115(5): 845-850.
  35. Brightbill, F. S., McDonnell, P. J., McGhee, CN. J., Farjo, A. A. and O. Serdarevic, M. D. (2008). Corneal Wound Healing by Sherwin T and Green CR in Corneal surgery, theory, and technique and tissue, Fourth Edition.
  36. Niederer, R. L., Sherwin, T. and McGhee, C. N. (2007). In vivo confocal microscopy of subepithelial infiltrates in human corneal transplant rejection. Cornea 26(4): 501-504.
  37. Niederer, R. L., Perumal, D., Sherwin, T. and McGhee, C. N. (2007). Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study. Br J Ophthalmol 91(9): 1165-1169.
  38. Niederer, R. L., Perumal, D., Sherwin, T. and McGhee, C. N. J. (2007). Corneal innervation and cellular changes following transplantation: an in vivo confocal microscopy study. Investigative Ophthalmology and Visual Science 48: 621-6.
  39. Patel, D. V., Sherwin, T. and McGhee, C. N. (2006). Laser scanning in vivo confocal microscopy of the normal human corneoscleral limbus. Invest Ophthalmol Vis Sci 47(7): 2823-2827.
  40. Patel, H. Y., Brookes, N. H., Moffatt, L., Sherwin, T., Ormonde, S., Clover, G. M. and McGhee, C. N. (2005). The New Zealand National Eye Bank study 1991-2003: a review of the source and management of corneal tissue. Cornea 24(5): 576-582.
  41. Sherwin, T. and Brookes, N. H. (2004). Morphological changes in keratoconus: pathology or pathogenesis. Clin Exp Ophthalmol 32(2): 211-217.
  42. Brookes, N. H., Loh, I-P., Clover, G. M., Poole, C. A. and Sherwin, T. (2003). Involvement of corneal nerves in the progression of kertoconus. Experimental Eye Research 77: 515-24.
  43. Craig, J. P., Grupcheva, C. N., Sherwin, T., McGhee, C. N. J. (2002). The role of in vivo confocal microscopy in the differential diagnosis of corneal oedema. Contact Lens and Anterior Eye 25: 37-38.
  44. Sherwin, T., Brookes, N. H., Loh, I. P., Poole, C. A. and Clover, G. M. (2002). Cellular incursion into Bowman's membrane in the peripheral cone of the keratoconic cornea. Exp Eye Res 74(4): 473-482.
  45. Craig, J. P., Sherwin, T., Grupcheva, C. N. and McGhee, C. N. J. (2002). Evolution of mucin balls; common, space-occupying, post-lens phenomena in high-Dk, silicone-hydrogel contact lens wear. Contact Lens and Anterior Eye 25: 38.
  46. Grupcheva, C. N., Malik, T. Y., Craig, J. P., Sherwin, T. and McGhee, C. N. (2001). Microstructural assessment of rare corneal dystrophies using real-time in vivo confocal microscopy. Clin Exp Ophthalmol 29(5): 281-285.
  47. Brookes, N. H., Sherwin, T., Poole, C. A. and Clover, G. (2001). Three dimensional multi-channel imaging in large volumes of the corneal stroma. Microscopy and Analysis 23: 5-7.
1 Protocol published
Implantation of Human Peripheral Corneal Spheres into Cadaveric Human Corneal Tissue
Authors:  Jeremy John Mathan, Salim Ismail, Jennifer Jane McGhee and Trevor Sherwin, date: 07/20/2017, view: 737, Q&A: 0
Stem and progenitor cells isolated from human limbal tissue can be cultured in vitro as spheres. These spheres have potential for use as transplantable elements for the repopulation of corneal tissue (Mathan et al., 2016). Herein ...