Sriram Ayyaswamy Department of Pathology, Texas Children’s Hospital and Baylor College of Medicine, USA
1 protocol

Thuy L. Phung
  • Department of Pathology, Texas Children’s Hospital and Baylor College of Medicine, USA
  • 1 Author merit


Ph.D, Cell Biology, Medical Scientist Training Program, University of Rochester School of Medicine and Dentistry, Rochester, NY. 

Ph.D Thesis Title: Physiological Function of Phosphoinositide 3-Kinase in Insulin-Dependent Regulation of Apolipoprotein B Metabolism in Rat Hepatocytes. 

Advisors: Janet D. Sparks, Ph.D and Charles Sparks, M.D, Department of Pathology and Laboratory Medicine

Current position

Associate Professor (with tenure), Associate Director of Global Pathology, Attending Dermatopathologist, Department of Pathology & Immunology, Baylor College of Medicine and Texas Children's Hospital


  1. Tian, L., Goldstein, A., Wang, H., Ching Lo, H., Sun Kim, I., Welte, T., Sheng, K., Dobrolecki, L. E., Zhang, X., Putluri, N., Phung, T. L., Mani, S. A., Stossi, F., Sreekumar, A., Mancini, M. A., Decker, W. K., Zong, C., Lewis, M. T. and Zhang, X. H. (2017). Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature 544(7649): 250-254.
  2. Phung, T. L., Wright, T. S., Pourciau, C. Y. and Smoller, B. R. (2017). Pediatric Dermatopathology. Spinger-Verlag.
  3. Phung, T. L. (Section Editor). (2016). Topical Collection on Tropical Dermatology. Current Tropical Medicine Reports.
  4. Van Minh, H., Van Duc, B. and Phung, T. L. (2016). Clinical Characteristics and Treatment of Leprosy. Current Tropical Medicine Report.
  5. Bokhary, M. and Phung, T. L. (2016). Molecular Pathogenesis of Leprosy. Current Tropical Medicine Reports.
  6. Hoang, M. V., Dang, P. V., Bui, D. V., Mejbel, H., Mani, D. T., Smoller, B. R. and Phung, T. L. (2015). Acquired cutis laxa associated with cutaneous mastocytosis. Dermatol Online J 21(7).
  7. Tran, T. T., Van Hoang, M., Phan, Q. N., Phung, T., Purschke, M., Farinelli, B., Sabir, S., Ziegler, A., Nelson, S. and Anderson, R. R. (2015). Fractional epidermal grafting in combination with laser therapy as a novel approach in treating radiation dermatitis. Semin Cutan Med Surg 34(1): 42-7.
  8. Phung, T. L., Du, W., Xue, Q., Ayyaswamy, S., Gerald, D., Antonello, Z., Nhek, S., Perruzzi, C. A., Acevedo, I., Ramanna-Valmiki, R., Rodriguez-Waitkus, P., Enayati, L., Hochman, M. L., Lev, D., Geeganage, S. and Benjamin, L. E. (2015). Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth. Cancer Res 75(1): 40-50.
  9. Jessup, C. J., Dishop, M. K., Metry, D. W., Rozell-Shannon, L., Phung, T. L. and Mihm Jr., M. C. (2015). Pathology of Congenital Vascular Lesions. In: Persky, Waner, Blei and Berenstein (Eds). Vascular Lesions of the Head and Neck: Diagnosis and Management. Thiema Medical Publishers.
  10. Phung, T. L. (2013). Molecular signaling pathways in infantile hemangioma. J SciMed Central Cell 1: 1004.
  11. Du, W., Gerald, D., Perruzzi, C. A., Rodriguez-Waitkus, P., Enayati, L., Krishnan, B., Edmonds, J., Hochman, M. L., Lev, D. C. and Phung, T. L. (2013). Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin. Lab Invest 93(10): 1115-1127.
  12. Kazerounian, S., Gerald, D., Huang, M., Chin, Y. R., Udayakumar, D., Zheng, N., O'Donnell, R. K., Perruzzi, C., Mangiante, L., Pourat, J., Phung, T. L., Bravo-Nuevo, A., Shechter, S., McNamara, S., Duhadaway, J. B., Kocher, O. N., Brown, L. F., Toker, A., Prendergast, G. C. and Benjamin, L. E. (2013). RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res 73(1): 50-61.
  13. Phung, T. L. and Hochman, M. (2012). Pathogenesis of infantile hemangioma. Facial Plast Surg 28(6): 554-562.
  14. Haws, A. L., Rojano, R., Tahan, S. R. and Phung, T. L. (2012). Accuracy of biopsy sampling for subtyping basal cell carcinoma. J Am Acad Dermatol 66(1): 106-111.
  15. Nelson, J. S., Jia, W., Phung, T. L. and Mihm, M. C., Jr. (2011). Observations on enhanced port wine stain blanching induced by combined pulsed dye laser and rapamycin administration. Lasers Surg Med 43(10): 939-942.
  16. Jia, W., Sun, V., Tran, N., Choi, B., Liu, S. W., Mihm, M. C., Jr., Phung, T. L. and Nelson, J. S. (2010). Long-term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: implications for effective port wine stain treatment. Lasers Surg Med 42(2): 105-112.
  17. Lahat, G., Dhuka, A. R., Hallevi, H., Xiao, L., Zou, C., Smith, K. D., Phung, T. L., Pollock, R. E., Benjamin, R., Hunt, K. K., Lazar, A. J. and Lev, D. (2010). Angiosarcoma: clinical and molecular insights. Ann Surg 251(6): 1098-1106.
  18. Xue, Q., Nagy, J. A., Manseau, E. J., Phung, T. L., Dvorak, H. F. and Benjamin, L. E. (2009). Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase. Arterioscler Thromb Vasc Biol 29(8): 1172-1178.
  19. Hu, S., Kim, C. C., Jessup, C., Phung, T. L. and Curiel-Lewandrowski, C. (2009). Primary cutaneous melanomas seen as inflamed pigmented lesions in patients undergoing adjuvant interferon treatment: a possible diagnostic clue for physicians. Arch Dermatol 145(5): 565-568.
  20. Karnes, J. C., Lee, B. T., Phung, T., Alomari, A. I., Mulliken, J. B. and Greene, A. K. (2009). Adult-onset kaposiform hemangioendothelioma in a posttraumatic site. Ann Plast Surg 62(4): 456-458.
  21. Metry, D. W., Garzon, M. C., Drolet, B. A., Frommelt, P., Haggstrom, A., Hall, J., Hess, C. P., Heyer, G. L., Siegel, D., Baselga, E., Katowitz, W., Levy, M. L., Mancini, A., Maronn, M. L., Phung, T., Pope, E., Sun, G. and Frieden, I. J. (2009). PHACE syndrome: current knowledge, future directions. Pediatr Dermatol 26(4): 381-398.
  22. Phung, T. L., Oble, D. A., Jia, W., Benjamin, L. E., Mihm, M. C., Jr. and Nelson, J. S. (2008). Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks. Lasers Surg Med 40(1): 1-5.
  23. Phung, T. L., Eyiah-Mensah, G., O'Donnell, R. K., Bieniek, R., Shechter, S., Walsh, K., Kuperwasser, C. and Benjamin, L. E. (2007). Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression. Cancer Res 67(11): 5070-5075.
  24. Phung, T. L., Ziv, K., Dabydeen, D., Eyiah-Mensah, G., Riveros, M., Perruzzi, C., Sun, J., Monahan-Earley, R. A., Shiojima, I., Nagy, J. A., Lin, M. I., Walsh, K., Dvorak, A. M., Briscoe, D. M., Neeman, M., Sessa, W. C., Dvorak, H. F. and Benjamin, L. E. (2006). Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell 10(2): 159-170.
  25. Sun, J. F., Phung, T., Shiojima, I., Felske, T., Upalakalin, J. N., Feng, D., Kornaga, T., Dor, T., Dvorak, A. M., Walsh, K. and Benjamin, L. E. (2005). Microvascular patterning is controlled by fine-tuning the Akt signal. Proc Natl Acad Sci U S A 102(1): 128-133.
  26. Phung, T. L., Hochman, M. and Mihm, M. C. (2005). Current knowledge of the pathogenesis of infantile hemangiomas. Arch Facial Plast Surg 7(5): 319-321.
  27. Phung, T. L., Pipkin, C. A., Tahan, S. R. and Chiu, D. S. (2004). Beta-lactam antibiotic-induced pseudoporphyria. J Am Acad Dermatol 51(2 Suppl): S80-82.
  28. Sparks, J. D., Phung, T. L., Bolognino, M., Cianci, J., Khurana, R., Peterson, R. G., Sowden, M. P., Corsetti, J. P. and Sparks, C. E. (1998). Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: hyperinsulinemic versus insulinopenic hyperglycemia. Metabolism 47(11): 1315-1324.
  29. Phung, T. L., Roncone, A., Jensen, K. L., Sparks, C. E. and Sparks, J. D. (1997). Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum. J Biol Chem 272(49): 30693-30702.
  30. Phung, T. L., Mooney, R. A., Kulas, D. T., Sparks, C. E. and Sparks, J. D. (1997). Suppression of the protein tyrosine phosphatase LAR reduces apolipoprotein B secretion by McA-RH7777 rat hepatoma cells. Biochem Biophys Res Commun 237(2): 367-371.
  31. Sparks, J. D., Phung, T. L., Bolognino, M. and Sparks, C. E. (1996). Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes. Biochem J 313 ( Pt 2): 567-574.
  32. Phung, T. L., Sowden, M. P., Sparks, J. D., Sparks, C. E. and Smith, H. C. (1996). Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat. Metabolism 45(9): 1056-1058.
1 Protocol published
A Novel Mouse Skin Graft Model of Vascular Tumors Driven by Akt1
Authors:  Thuy L. Phung and Sriram Ayyaswamy, date: 07/05/2017, view: 1157, Q&A: 0
To investigate whether endothelial Akt1 activation is sufficient to induce vascular tumor formation in the skin, we have developed a skin graft model in which a skin fragment from transgenic donor mice with inducible and endothelial cell-specific ...