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Coauthors
Klaus Willecke LIMES Institute, Molecular Genetics, University of Bonn, Germany
1 protocol

Philipp Wörsdörfer
  • Institute of Anatomy and Cell Biology, University of Würzburg, Germany
Contributions
  • 1 Author merit

Education

Ph.D, University of Bonn, Germany, 2010

Current position

PostDoc, Institute of Anatomy and Cell Biology, University of Würzburg, Germany

Publications

  1. Worsdorfer, P., Bosen, F., Gebhardt, M., Russ, N., Zimmermann, K., Komla Kessie, D., Sekaran, T., Egert, A., Ergun, S., Schorle, H., Pfeifer, A., Edenhofer, F. and Willecke, K. (2017). Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies. Stem Cells 35(4): 859-871.
  2. Worsdorfer, P., Mekala, S. R., Bauer, J., Edenhofer, F., Kuerten, S. and Ergun, S. (2017). The vascular adventitia: An endogenous, omnipresent source of stem cells in the body. Pharmacol Ther 171: 13-29.
  3. Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M. C., Altamura, S., Reyes, A., Prendergast, A. M., Baumgartner, D., Carnevalli, L. S., Atzberger, A., Haas, S., von Paleske, L., Boroviak, T., Worsdorfer, P., Essers, M. A., Kloz, U., Eisenman, R. N., Edenhofer, F., Bertone, P., Huber, W., van der Hoeven, F., Smith, A. and Trumpp, A. (2016). Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell 164(4): 668-680.
  4. Bung, R., Worsdorfer, P., Thier, M. C., Lemke, K., Gebhardt, M. and Edenhofer, F. (2016). Partial Dedifferentiation of Murine Radial Glia-Type Neural Stem Cells by Brn2 and c-Myc Yields Early Neuroepithelial Progenitors. J Mol Biol 428(7): 1476-1483.
  5. Meyer, S., Worsdorfer, P., Gunther, K., Thier, M. and Edenhofer, F. (2015). Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells. J Vis Exp (101): e52831.
  6. Worsdorfer, P., Thier, M., Kadari, A. and Edenhofer, F. (2013). Roadmap to cellular reprogramming--manipulating transcriptional networks with DNA, RNA, proteins and small molecules. Curr Mol Med 13(5): 868-878.
  7. Hennen, E., Safina, D., Haussmann, U., Worsdorfer, P., Edenhofer, F., Poetsch, A. and Faissner, A. (2013). A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice. J Biol Chem 288(23): 16538-16545.
  8. Schmidt, V. J., Jobs, A., von Maltzahn, J., Worsdorfer, P., Willecke, K. and de Wit, C. (2012). Connexin45 is expressed in vascular smooth muscle but its function remains elusive. PLoS One 7(7): e42287.
  9. Thier, M., Worsdorfer, P., Lakes, Y. B., Gorris, R., Herms, S., Opitz, T., Seiferling, D., Quandel, T., Hoffmann, P., Nothen, M. M., Brustle, O. and Edenhofer, F. (2012). Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 10(4): 473-479.
  10. Zlomuzica, A., Reichinnek, S., Maxeiner, S., Both, M., May, E., Worsdorfer, P., Draguhn, A., Willecke, K. and Dere, E. (2010). Deletion of connexin45 in mouse neurons disrupts one-trial object recognition and alters kainate-induced gamma-oscillations in the hippocampus. Physiol Behav 101(2): 245-253.
  11. Dobrowolski, R., Hertig, G., Lechner, H., Worsdorfer, P., Wulf, V., Dicke, N., Eckert, D., Bauer, R., Schorle, H. and Willecke, K. (2009). Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum Mol Genet 18(15): 2899-2911.
  12. von Maltzahn, J., Kreuzberg, M. M., Matern, G., Euwens, C., Hoher, T., Worsdorfer, P. and Willecke, K. (2009). C-terminal tagging with eGFP yields new insights into expression of connexin45 but prevents rescue of embryonic lethal connexin45-deficient mice. Eur J Cell Biol 88(9): 481-494.
  13. Worsdorfer, P., Maxeiner, S., Markopoulos, C., Kirfel, G., Wulf, V., Auth, T., Urschel, S., von Maltzahn, J. and Willecke, K. (2008). Connexin expression and functional analysis of gap junctional communication in mouse embryonic stem cells. Stem Cells 26(2): 431-439.
  14. Schnichels, M., Worsdorfer, P., Dobrowolski, R., Markopoulos, C., Kretz, M., Schwarz, G., Winterhager, E. and Willecke, K. (2007). The connexin31 F137L mutant mouse as a model for the human skin disease erythrokeratodermia variabilis (EKV). Hum Mol Genet 16(10): 1216-1224.
  15. Urschel, S., Hoher, T., Schubert, T., Alev, C., Sohl, G., Worsdorfer, P., Asahara, T., Dermietzel, R., Weiler, R. and Willecke, K. (2006). Protein kinase A-mediated phosphorylation of connexin36 in mouse retina results in decreased gap junctional communication between AII amacrine cells. J Biol Chem 281(44): 33163-33171.
1 Protocol published
Functional Analysis of Connexin Channels in Cultured Cells by Neurobiotin Injection and Visualization
Authors:  Philipp Wörsdörfer and Klaus Willecke, date: 06/05/2017, view: 946, Q&A: 0
Functional gap junction channels between neighboring cells can be assessed by microinjection of low molecular weight tracer substances into cultured cells. The extent of direct intercellular communication can be precisely quantified by this method. ...