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Sneh Singh Jawaharlal Nehru University
1 protocol

Sneha Sudha Komath
  • School of Life Sciences, Jawaharlal Nehru University, India
  • 1 Author merit

Education

Ph.D, School of Chemistry, University of Hyderabad (Hyderabad), India, 1998

Current position

Professor, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

Publications

  1. Singh, S. L., Rai, R. C., Sah, S. K. and Komath, S. S. (2016). The catalytic subunit of the first mannosyltransferase in the GPI biosynthetic pathway affects growth, cell wall integrity and hyphal morphogenesis in Candida albicans. Yeast 33(8): 365-383.
  2. Ahmad, M. F., Mann, P. G. and Komath, S. S. (2015). A signal with a difference: the role of GPI anchor signal sequence in dictating conformation and function of the Als5 adhesin in candida albicans. Adv Exp Med Biol 842: 147-163.
  3. Yadav, A., Singh, S. L., Yadav, B. and Komath, S. S. (2014). Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homolog in Candida albicans. Glycoconj J 31(6-7): 497-507.
  4. Yadav, B., Bhatnagar, S., Ahmad, M. F., Jain, P., Pratyusha, V. A., Kumar, P. and Komath, S. S. (2014). First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans. J Biol Chem 289(6): 3365-3382.
  5. Ashraf, M., Sreejith, P., Yadav, U. and Komath, S. S. (2013). Catalysis by N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase (PIG-L) from Entamoeba histolytica: new roles for conserved residues. J Biol Chem 288(11): 7590-7595.
  6. Victoria, G. S., Yadav, B., Hauhnar, L., Jain, P., Bhatnagar, S. and Komath, S. S. (2012). Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans. Biochem J 443(3): 619-625.
  7. Ahmad, M. F., Yadav, B., Kumar, P., Puri, A., Mazumder, M., Ali, A., Gourinath, S., Muthuswami, R. and Komath, S. S. (2012). The GPI anchor signal sequence dictates the folding and functionality of the Als5 adhesin from Candida albicans. PLoS One 7(4): e35305.
  8. Ashraf, M., Yadav, B., Perinthottathil, S., Kumar, K. S., Vats, D., Muthuswami, R. and Komath, S. S. (2011). N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase from Entamoeba histolytica: metal alters catalytic rates but not substrate affinity. J Biol Chem 286(4): 2543-2549.
  9. Victoria, G. S., Kumar, P. and Komath, S. S. (2010). The Candida albicans homologue of PIG-P, CaGpi19p: gene dosage and role in growth and filamentation. Microbiology 156(Pt 10): 3041-3051.
1 Protocol published
Fluorescently Labelled Aerolysin (FLAER) Labelling of Candida albicans Cells
Authors:  Sneh Lata Singh and Sneha Sudha Komath, date: 06/05/2017, view: 1151, Q&A: 0
In this protocol we describe a nonradiolabelled labelling of GPI anchor in Candida albicans. The method uses a fluorescent probe to bind specifically to GPI anchors so that the level of GPI-anchored proteins at the cell surface can be ...