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Coauthors
Anna Krasnodembskaya Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Northern Ireland
1 protocol

Megan V Jackson
  • Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Northern Ireland
  • 1 Author merit

Education

Ph.D, Queen's University Belfast, Northern Ireland, 2011

Current position

Postdoctoral research fellow, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland

Publications

  1. Jackson, M. V., Morrison, T. J., Doherty, D. F., McAuley, D. F., Matthay, M. A., Kissenpfennig, A., O'Kane, C. M. and Krasnodembskaya, A. D. (2016). Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS. Stem Cells 34(8): 2210-2223.
    Figure from paper chosen for front cover for Stem Cells Aug 2016 edition (http://onlinelibrary.wiley.com/doi/10.1002/stem.v34.8/issuetoc) and 4th most downloaded manuscript in 2016 (Jan Nolta, Editor, Stem Cells http://onlinelibrary.wiley.com/doi/10.1002/stem.2547/full)
  2. Jackson, M., Morrison, T., McAuley, D., O'Kane, C., Matthay, M. and Krasnodembskaya, A. (2016). Mesenchymal stromal cells (MSC) anti-microbial effect in acute respiratory distress syndrome (ARDS) is mediated in part by enhanced alveolar macrophage phagocytosis through cell contact-dependent mitochondrial transfer leading to improved macrophage bioenergetics. Eur Respir J 48: PA939.
  3. Jackson, M. V., Morrison, T. J., McAuley, D. F., Matthay, M. A., O'Kane, C. M., Krasnodembskaya, A. D. (2016). Mitochondrial Transfer Via Tunnelling Nanotubes (TNT) Is A Novel Mechanism By Which Mesenchymal Stromal Cells Enhance Macrophage Phagocytosis In In Vivo Models Of Acute Lung Injury. Am J Respir Crit Care Med 193: A6607.
  4. Jackson, M. V., Morrison, T. J., O'Kane, C., McAuley, D. F. and Krasnodembskaya, A. D. (2015). Mitochondrial transfer is an important mechanism by which Mesenchymal Stromal Cells (MSC) facilitate macrophage phagocytosis in the in vitro and in vivo models of Acute Respiratory Distress Syndrome (ARDS). Thorax 70: A1-A2.
  5. O'Kane, D., Jackson, M. V., Kissenpfennig, A., Spence, S., Damkat-Thomas, L., Tolland, J. P., Smyth, A. E., Denton, C. P., Elborn, J. S., McAuley, D. F. and O'Kane, C. M. (2014). SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in vitro. Exp Dermatol 23(7): 497-503.
  6. Jackson, M. V., Tunny, M. M., Elborn, J. S. and O'Kane, C. (2013). A clinical isolate of Prevotella histicola drives MMP-9 secretion through mitogen activated protein kinase dependent mechanisms in Monocytes. Pediatr Pulmonol 48: 319-319.
  7. Jackson, M. V., O'Kane, C. M., Tunny, M. M. and Elborn, J. S. (2012). WS9.1 Clinical isolates of Prevotella histicola drive MMP-9 secretion by mononuclear cells. J Cyst Fibros 11: S19.
1 Protocol published
Analysis of Mitochondrial Transfer in Direct Co-cultures of Human Monocyte-derived Macrophages (MDM) and Mesenchymal Stem Cells (MSC)
Authors:  Megan V. Jackson and Anna D. Krasnodembskaya, date: 05/05/2017, view: 1680, Q&A: 0
Mesenchymal stem/stromal cells (MSC) are adult stem cells which have been shown to improve survival, enhance bacterial clearance and alleviate inflammation in pre-clinical models of acute respiratory distress syndrome (ARDS) and sepsis. These ...