Paula Hurley The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, USA
1 protocol

Robert Hughes The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, USA
1 protocol

Brian W. Simons
  • The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, USA
  • 1 Author merit


Ph.D. Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, 2014

Current position

Assistant Professor, Johns Hopkins University School of Medicine


  1. Benzon, B., Zhao, S. G., Haffner, M. C., Takhar, M., Erho, N., Yousefi, K., Hurley, P., Bishop, J. L., Tosoian, J., Ghabili, K., Alshalalfa, M., Glavaris, S., Simons, B. W., Tran, P., Davicioni, E., Karnes, R. J., Boudadi, K., Antonarakis, E. S., Schaeffer, E. M., Drake, C. G., Feng, F. and Ross, A. E. (2017). Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis. Prostate Cancer Prostatic Dis 20(1): 28-35.
  2. Sharrow, A. C., Perkins, B., Collector, M. I., Yu, W., Simons, B. W. and Jones, R. J. (2016). Characterization of aldehyde dehydrogenase 1 high ovarian cancer cells: Towards targeted stem cell therapy. Gynecol Oncol 142(2): 341-348.
  3. Hurley, P. J., Sundi, D., Shinder, B., Simons, B. W., Hughes, R. M., Miller, R. M., Benzon, B., Faraj, S. F., Netto, G. J., Vergara, I. A., Erho, N., Davicioni, E., Karnes, R. J., Yan, G., Ewing, C., Isaacs, S. D., Berman, D. M., Rider, J. R., Jordahl, K. M., Mucci, L. A., Huang, J., An, S. S., Park, B. H., Isaacs, W. B., Marchionni, L., Ross, A. E. and Schaeffer, E. M. (2016). Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. Clin Cancer Res 22(2): 448-458.
  4. Hurley, P. J., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. S. and Schaeffer, E. M. (2015). Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression. Cancer Res 75(20): 4322-4334.
  5. Sfanos, K. S., Canene-Adams, K., Hempel, H., Yu, S. H., Simons, B. W., Schaeffer, A. J., Schaeffer, E. M., Nelson, W. G. and De Marzo, A. M. (2015). Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP)-Induced Cancer at Multiple Sites. Cancer Prev Res (Phila) 8(8): 683-692.
  6. Kelly, K. M., Wack, A. N., Bradway, D., Simons, B. W., Bronson, E., Osterhout, G., Parrish, N. M. and Montali, R. J. (2015). Identification Of Mycobacterium Genavense In a Diana Monkey (Cercopithecus Diana) by Polymerase Chain Reaction And High-Performance Liquid Chromatography. J Zoo Wildl Med 46(2): 339-344.
  7. Simons, B. W., Durham, N. M., Bruno, T. C., Grosso, J. F., Schaeffer, A. J., Ross, A. E., Hurley, P. J., Berman, D. M., Drake, C. G., Thumbikat, P. and Schaeffer, E. M. (2015). A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression. J Pathol 235(3): 478-489.
  8. Yang, M., Yu, T., Wang, Y. Y., Lai, S. K., Zeng, Q., Miao, B., Tang, B. C., Simons, B. W., Ensign, L. M., Liu, G., Chan, K. W., Juang, C. Y., Mert, O., Wood, J., Fu, J., McMahon, M. T., Wu, T. C., Hung, C. F. and Hanes, J. (2014). Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth. Adv Healthc Mater 3(7): 1044-1052.
  9. Saxena, P., Simons, B. W., Gabrielson, K., Haito-Chavez, Y., Valeshabad, A. K., Kumbhari, V., Singh, V. K., Lennon, A. M., Canto, M. I., Pasricha, P. J., Kalloo, A. and Khashab, M. A. (2014). A novel viscous dissecting gel for endoscopic submucosal dissection: a prospective survival study in a porcine model. Endoscopy 46(7): 605-609.
  10. Carvalho, F. L., Simons, B. W., Eberhart, C. G. and Berman, D. M. (2014). Notch signaling in prostate cancer: a moving target. Prostate 74(9): 933-945.
  11. Yang, M., Yu, T., Wood, J., Wang, Y. Y., Tang, B. C., Zeng, Q., Simons, B. W., Fu, J., Chuang, C. M., Lai, S. K., Wu, T. C., Hung, C. F. and Hanes, J. (2014). Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model. Drug Deliv Transl Res 4(2): 203-209.
  12. Pascal, L. E., Ai, J., Masoodi, K. Z., Wang, Y., Wang, D., Eisermann, K., Rigatti, L. H., O'Malley, K. J., Ma, H. M., Wang, X., Dar, J. A., Parwani, A. V., Simons, B. W., Ittman, M. M., Li, L., Davies, B. J. and Wang, Z. (2013). Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice. PLoS One 8(11): e79542.
  13. Ittmann, M., Huang, J., Radaelli, E., Martin, P., Signoretti, S., Sullivan, R., Simons, B. W., Ward, J. M., Robinson, B. D., Chu, G. C., Loda, M., Thomas, G., Borowsky, A. and Cardiff, R. D. (2013). Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. Cancer Res 73(9): 2718-2736.
  14. Carvalho, F. L., Simons, B. W., Antonarakis, E. S., Rasheed, Z., Douglas, N., Villegas, D., Matsui, W. and Berman, D. M. (2013). Tumorigenic potential of circulating prostate tumor cells. Oncotarget 4(3): 413-421.
  15. Simons, B. W., Hurley, P. J., Huang, Z., Ross, A. E., Miller, R., Marchionni, L., Berman, D. M. and Schaeffer, E. M. (2012). Wnt signaling though beta-catenin is required for prostate lineage specification. Dev Biol 371(2): 246-255.
  16. Hurley, P. J., Marchionni, L., Simons, B. W., Ross, A. E., Peskoe, S. B., Miller, R. M., Erho, N., Vergara, I. A., Ghadessi, M., Huang, Z., Gurel, B., Park, B. H., Davicioni, E., Jenkins, R. B., Platz, E. A., Berman, D. M. and Schaeffer, E. M. (2012). Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome. Proc Natl Acad Sci U S A 109(37): 14977-14982.
  17. Huang, Z., Hurley, P. J., Simons, B. W., Marchionni, L., Berman, D. M., Ross, A. E. and Schaeffer, E. M. (2012). Sox9 is required for prostate development and prostate cancer initiation. Oncotarget 3(6): 651-663.
  18. Kedziorek, D. A., Hofmann, L. V., Fu, Y., Gilson, W. D., Cosby, K. M., Kohl, B., Barnett, B. P., Simons, B. W., Walczak, P., Bulte, J. W., Gabrielson, K. and Kraitchman, D. L. (2012). X-ray-visible microcapsules containing mesenchymal stem cells improve hind limb perfusion in a rabbit model of peripheral arterial disease. Stem Cells 30(6): 1286-1296.
  19. Boylan, N. J., Kim, A. J., Suk, J. S., Adstamongkonkul, P., Simons, B. W., Lai, S. K., Cooper, M. J. and Hanes, J. (2012). Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-L-lysine. Biomaterials 33(7): 2361-2371.
  20. Shabbeer, S., Williams, S. A., Simons, B. W., Herman, J. G. and Carducci, M. A. (2012). Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence. Cancer Prev Res (Phila) 5(2): 229-239.
1 Protocol published
A Murine Orthotopic Allograft to Model Prostate Cancer Growth and Metastasis
Authors:  Robert M. Hughes, Brian W. Simons and Paula J. Hurley, date: 02/20/2017, view: 2035, Q&A: 0
Prostate cancer is one of the most common cancers in men in the United States. Comprehensive understanding of the biology contributing to prostate cancer will have important clinical implications. Animal models have greatly impacted our knowledge of ...