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Coauthors
Javier Di Noia Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Anne-Marie Patenaude Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Stephen Methot Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Ludivine Litzler Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Astrid Zahn
  • Institut de Recherches Cliniques de Montréal, Canada
  • 1 Author merit

Education

Ph.D., University of Cambridge, UK

Current position

Research associate, IRCM, Montreal, Canada

Publications

  1. Montamat-Sicotte, D., Litzler, L. C., Abreu, C., Safavi, S., Zahn, A., Orthwein, A., Muschen, M., Oppezzo, P., Munoz, D. P. and Di Noia, J. M. (2015). HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol 45(8): 2365-2376.
  2. Methot, S. P., Litzler, L. C., Trajtenberg, F., Zahn, A., Robert, F., Pelletier, J., Buschiazzo, A., Magor, B. G. and Di Noia, J. M. (2015). Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J Exp Med 212(4): 581-596.
  3. Collin, R., Dugas, V., Chabot-Roy, G., Salem, D., Zahn, A., Di Noia, J. M., Rauch, J. and Lesage, S. (2015). Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12. J Autoimmun 58: 90-99.
  4. Zahn, A., Eranki, A. K., Patenaude, A. M., Methot, S. P., Fifield, H., Cortizas, E. M., Foster, P., Imai, K., Durandy, A., Larijani, M., Verdun, R. E. and Di Noia, J. M. (2014). Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc Natl Acad Sci U S A 111(11): E988-997.
  5. Cortizas, E. M., Zahn, A., Hajjar, M. E., Patenaude, A. M., Di Noia, J. M. and Verdun, R. E. (2013). Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination. J Immunol 191(11): 5751-5763.
  6. Zahn, A., Daugan, M., Safavi, S., Godin, D., Cheong, C., Lamarre, A. and Di Noia, J. M. (2013). Separation of function between isotype switching and affinity maturation in vivo during acute immune responses and circulating autoantibodies in UNG-deficient mice. J Immunol 190(12): 5949-5960.
  7. Orthwein, A., Zahn, A., Methot, S. P., Godin, D., Conticello, S. G., Terada, K. and Di Noia, J. M. (2012). Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. EMBO J 31(3): 679-691.
  8. Zahn, A., Li, C., Danso, K., Candotti, D., Owusu-Ofori, S., Temple, J. and Allain, J. P. (2008). Molecular characterization of occult hepatitis B virus in genotype E-infected subjects. J Gen Virol 89(Pt 2): 409-418.
  9. Zahn, A. and Allain, J. P. (2005). Hepatitis C virus and hepatitis B virus bind to heparin: purification of largely IgG-free virions from infected plasma by heparin chromatography. J Gen Virol 86(Pt 3): 677-685.
  10. Zahn, A. and Allain, J. P. (2005). Hepatitis C virus and hepatitis B virus bind to heparin: purification of largely IgG-free virions from infected plasma by heparin chromatography. J Gen Virol 86(Pt 3): 677-685.
  11. Zahn, A., Furlong, L. I., Biancotti, J. C., Ghiringhelli, P. D., Marijn-Briggiler, C. I. and Vazquez-Levin, M. H. (2002). Evaluation of the proacrosin/acrosin system and its mechanism of activation in human sperm extracts. J Reprod Immunol 54(1-2): 43-63.
1 Protocol published
Cell-based Assays to Monitor AID Activity
The enzyme Activation induced deaminase (AID) underpins antibody affinity maturation and isotype switching through its mutagenic activity of deaminating deoxycytidine to deoxyuridine in DNA. Subsequent processing of the deoxyuridine initiates the ...