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Coauthors
Javier Di Noia Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Astrid Zahn Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Stephen Methot Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Ludivine Litzler Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Anne-Marie Patenaude
  • Institut de Recherches Cliniques de Montréal, Canada
  • 1 Author merit

Education

M.S., McGill University

Current position

Research assistant, IRCM, Montreal, QC, Canada

Publications

  1. Zahn, A., Eranki, A. K., Patenaude, A. M., Methot, S. P., Fifield, H., Cortizas, E. M., Foster, P., Imai, K., Durandy, A., Larijani, M., Verdun, R. E. and Di Noia, J. M. (2014). Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc Natl Acad Sci U S A 111(11): E988-997.
  2. Cortizas, E. M., Zahn, A., Hajjar, M. E., Patenaude, A. M., Di Noia, J. M. and Verdun, R. E. (2013). Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination. J Immunol 191(11): 5751-5763.
  3. Campo, V. A., Patenaude, A. M., Kaden, S., Horb, L., Firka, D., Jiricny, J. and Di Noia, J. M. (2013). MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils. Nucleic Acids Res 41(5): 3032-3046.
  4. Orthwein, A., Patenaude, A. M., Affar el, B., Lamarre, A., Young, J. C. and Di Noia, J. M. (2010). Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. J Exp Med 207(12): 2751-2765.
  5. Patenaude, A. M. and Di Noia, J. M. (2010). The mechanisms regulating the subcellular localization of AID. Nucleus 1(4): 325-331.
  6. Patenaude, A. M., Orthwein, A., Hu, Y., Campo, V. A., Kavli, B., Buschiazzo, A. and Di Noia, J. M. (2009). Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol 16(5): 517-527.
  7. Torban, E., Patenaude, A. M., Leclerc, S., Rakowiecki, S., Gauthier, S., Andelfinger, G., Epstein, D. J. and Gros, P. (2008). Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci U S A 105(9): 3449-3454.
  8. Iglesias, D. M., Hueber, P. A., Chu, L., Campbell, R., Patenaude, A. M., Dziarmaga, A. J., Quinlan, J., Mohamed, O., Dufort, D. and Goodyer, P. R. (2007). Canonical WNT signaling during kidney development. Am J Physiol Renal Physiol 293(2): F494-500.
  9. Torban, E., Wang, H. J., Patenaude, A. M., Riccomagno, M., Daniels, E., Epstein, D. and Gros, P. (2007). Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation. Gene Expr Patterns 7(3): 346-354.
1 Protocol published
Cell-based Assays to Monitor AID Activity
The enzyme Activation induced deaminase (AID) underpins antibody affinity maturation and isotype switching through its mutagenic activity of deaminating deoxycytidine to deoxyuridine in DNA. Subsequent processing of the deoxyuridine initiates the ...