Ana Perez-Villalba Centro de Investigaciones Biomédicas en Red sobre Enfermedades Neurodegenerativas, Universidad de Valencia, Spain
2 protocols

Emmanuelle Berret Brain Mind Institute, Laboratory of Synaptic Mechanisms (LSYM), Ecole Polytechnique Fédérale de Lausanne (EPFL)
7 protocols

Manuel Gahete IMIBIC - Maimonides Institute for Biomedical Research of Córdoba
4 protocols

Shai Berlin
  • The Ruth and Bruce Rappaport Faculty of Medicine, Technion- Israel Institute of Technology (+972)-4-829-5346 1 Efron st. Bat Galim Haifa, 3525433, Israel
Research focus
  • Neuroscience
  • 5 Reviewer merit


Ph.D. in Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel, 2011

Current position

I am currently an assistant professor at the Rappaport Faculty of Medicine- Technion, Israel. My research focuses on the development of sensors and optogenetic tools for the study of synaptic plasticity.


  1. Snir, S. and Berlin S. (2017). Bringing Synthetic Optogenetics to the Clinic. J Cell Signal 2(2): 152-153.
  2. Kahanovitch, U., Berlin, S. and Dascal, N. (2017). Collision coupling in the GABAB receptor - G protein - GIRK signaling cascade. FEBS Lett.
  3. Berlin, S. and Isacoff, E. Y. (2017). Synapses in the spotlight with synthetic optogenetics. EMBO Rep 18(5): 677-692.
  4. Berlin, S. and Isacoff, E. Y. (2017). Optical Control of Glutamate Receptors of the NMDA-kind in Mammalian Neurons, with the use of Photoswitchable Ligands. In: Parrot, S. (ed). Biochemical Approaches to Glutamatergic Neurotransmission, Neuromethods, Chapter 10; vol. 130. Springer Science+Business Media LLC. (FRONT COVER article)
  5. Berlin, S., Szobota, S., Reiner, A., Carroll, E. C., Kienzler, M. A., Guyon, A., Xiao, T., Tauner, D. and Isacoff, E. Y. (2016). A family of photoswitchable NMDA receptors. Elife 5. (Epub ahead of print) 
  6. Berlin, S., Carroll, E. C., Newman, Z. L., Okada, H. O., Quinn, C. M., Kallman, B., Rockwell, N. C., Martin, S. S., Lagarias, J. C. and Isacoff, E. Y. (2015). Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging. Nat Methods. (Epub ahead of print)
  7. Yakubovich, D.*, Berlin, S.*, Kahanovitch, U.*, Rubinstein, M., Farhy-Tselnicker, I., Styr, B., Keren-Raifman, T., Dessauer, C. W. and Dascal, N. (2015). A quantitative model of the GIRK1/2 channel reveals that its basal and evoked activities are controlled by unequal stoichiometry of galpha and gbetagamma. PLoS Comput Biol 11(11): e1004598. (*Co-1st authors) 
  8. Berlin, S. (2015). Paper-trail index: Can a metric that captures a paper's history of submission and rejection give insight into its value and encourage good authorship practices? EMBO Rep 16(8): 889-893.   
  9. Carroll, E. C., Berlin, S., Levitz, J., Kienzler, M. A., Yuan, Z., Madsen, D., Larsen, D. S. and Isacoff, E. Y. (2015). Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. Proc Natl Acad Sci U S A 112(7): E776-785.
  10. Friedmann, D., Hoagland, A., Berlin, S. and Isacoff, E. Y. (2015). A spinal opsin controls early neural activity and drives a behavioral light response. Curr Biol 25(1): 69-74.   
  11. Kahanovitch, U., Tsemakhovich, V., Berlin, S., Rubinstein, M., Styr, B., Castel, R., Peleg, S., Tabak, G., Dessauer, C. W., Ivanina, T. and Dascal, N. (2014). Recruitment of Gbetagamma controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1. J Physiol 592(Pt 24): 5373-5390.
  12. Greitzer-Antes, D., Barak-Broner, N., Berlin, S., Oron, Y., Chikvashvili, D. and Lotan, I. (2013). Tracking Ca2+-dependent and Ca2+-independent conformational transitions in syntaxin 1A during exocytosis in neuroendocrine cells. J Cell Sci 126(Pt 13): 2914-2923.
  13. Berlin, S., Tsemakhovich, V. A., Castel, R., Ivanina, T., Dessauer, C. W., Keren-Raifman, T. and Dascal, N. (2011). Two distinct aspects of coupling between Galpha(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Galpha(i3) protein subunits. J Biol Chem 286(38): 33223-33235.
  14.  Berlin, S. (2010). It takes two to tango. EMBO Rep 11(3): 150-151; author reply 151-152. 
  15. Berlin, S. (2009). Do bigger and "better" labs have easier access to high impact factor journals? Science signaling. E-letter.
  16. Berlin, S., Keren-Raifman, T., Castel, R., Rubinstein, M., Dessauer, C. W., Ivanina, T. and Dascal, N. (2010). G alpha(i) and G betagamma jointly regulate the conformations of a G betagamma effector, the neuronal G protein-activated K+ channel (GIRK). J Biol Chem 285(9): 6179-6185.
  17. Lvov, A., Greitzer, D., Berlin, S., Chikvashvili, D., Tsuk, S., Lotan, I. and Michaelevski, I. (2009). Rearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gating. J Biol Chem 284(41): 28276-28291.
  18. Rubinstein, M., Peleg, S., Berlin, S., Brass, D., Keren-Raifman, T., Dessauer, C. W., Ivanina, T. and Dascal, N. (2009). Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma. J Physiol 587(Pt 14): 3473-3491.
  19. Rubinstein, M., Peleg, S., Berlin, S., Brass, D. and Dascal, N. (2007). Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes. J Physiol 581(Pt 1): 17-32.
  20.  Eliyahu, U., Berlin, S., Hadad, E., Heled, Y. and Moran, D. S. (2007). Psychostimulants and military operations. Mil Med 172(4): 383-387.
  21. Berlin, S., Shalit, L., Yarom, Y. and Moran, D. S. (2007). Metabolic rate prediction by massless actigraphy for outdoor activities. Mil Med 172(8): 882-887.
  22. Berlin, S., Hadad, E., Heled, Y. and Moran, S. D. (2004). The efficacy of nutritional supplements upon physical exercise. Journal of Israeli Military Medicine 1(2): 72-80.
5 Protocols reviewed
In vitro Brainstem-spinal Cord Preparation from Newborn Rat
Authors:  Jean-Patrick Le Gal, Angelo Nicolosi, Laurent Juvin and Didier Morin, date: 11/20/2016, view: 1720, Q&A: 0
The brainstem-spinal cord preparation of newborn rat contains neural networks able to produce motor output in absence of sensory feedback. These neural structures, commonly called central pattern generators (CPGs), are involved in many vital ...
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In vitro Assay for Dendritic Spine Retraction of Hippocampal Neurons with Sparse Labeling
Authors:  Ryohei Iwata and Takuji Iwasato, date: 09/20/2016, view: 1775, Q&A: 0
Dendritic spines are the post-synaptic structures that play a central role in excitatory synaptic transmission. Developmental spinogenesis relies on a variety of stimuli such as those derived from cell-cell communication and their downstream ...
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