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Coreviewers
Yanjie Li Yale University
28 protocols

Editor
Alessandro Didonna
  • Adjunct Instructor, University of California, San Francisco
Research focus
  • Neuroscience
  • Neurodegeneration; Multiple Sclerosis; Autoimmunity; Protein Misfolding; Movement Disorders.
Contributions
  • 2 Reviewer merit

Education

Ph.D. in Functional and Structural Genomics, International School for Advanced Studies (SISSA), 2010

Lab information

Multiple Sclerosis Genetics Research Lab

Publications

1. Didonna A, Oksenberg JR. Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. Ian S. Zagon and Patricia J. McLaughlin (Editors). The Genetics of Multiple Sclerosis. 2017; 3-16.

2. Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33):E6982-E6991.

3. Didonna A, Opal P. Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurol. 2016 Dec 01; 73(12):1485-1490.

4. Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 Aug 22; 6:31603.

5. Didonna A, Benetti F. Post-translational modifications in neurodegeneration. AIMS Biophysics. 2016; 1(3):27-49.

6. Didonna A. Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Curr Med Chem. 2016; 23(14):1442-59.

7. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8.

8. Didonna A, Venturini AC, Hartman K, Vranac T, Curin Šerbec V, Legname G. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 2015; 3:e811.

9. Didonna A, Oksenberg JR. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22.

10. Didonna A, Opal P. The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol. 2015 Jan; 2(1):79-101.

11. Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15; 23(14):3733-45.

12. Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May; 123(5):1964-75.

13. Didonna A. Prion protein and its role in signal transduction. Cell Mol Biol Lett. 2013 Jun; 18(2):209-30.

14. Didonna A, Sussman J, Benetti F, Legname G. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012 Jul 01; 6(3):309-16.

15. Didonna A, Vaccari L, Bek A, Legname G. Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS Chem Neurosci. 2011 Mar 16; 2(3):160-74.

16. Didonna A, Legname G. Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener. 2010 Aug 09; 5:29.

2 Protocols reviewed
Purifying Properly Folded Cysteine-rich, Zinc Finger Containing Recombinant Proteins for Structural Drug Targeting Studies: the CH1 Domain of p300 as a Case Example
Authors:  Yong Joon Kim, Stefan Kaluz, Anil Mehta, Emily Weinert, Shannon Rivera and Erwin G. Van Meir, date: 09/05/2017, view: 637, Q&A: 0
The transcription factor Hypoxia-Inducible Factor (HIF) complexes with the coactivator p300, activating the hypoxia response pathway and allowing tumors to grow. The CH1 and CAD domains of each respective protein form the interface between p300 and ...
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An ex vivo Perifusion Method for Quantitative Determination of Neuropeptide Release from Mouse Hypothalamic Explants
Authors:  Ophélia Le Thuc, Jacques Noël and Carole Rovère, date: 08/20/2017, view: 781, Q&A: 0
The hypothalamus is a primary brain area which, in mammals, regulates several physiological functions that are all related to maintaining general homeostasis, by linking the central nervous system (CNS) and the periphery. The hypothalamus itself can ...
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