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Coauthors
Kim Midwood Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
1 protocol

Lorena Zuliani-Alvarez Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
1 protocol

Anna Maria Piccinini
  • Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
Contributions
  • 1 Author merit

Education

Ph.D, Karl Franzens University, Graz, Austria, 2007

Current position

Anne McLaren Fellow, School of Pharmacy, The University of Nottingham, United Kingdom

Publications

  1. Piccinini, A. M., Zuliani-Alvarez, L., Lim, J. M. and Midwood, K. S. (2016). Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages. Sci Signal 9(443): ra86.
  2. Gschwandtner, M., Piccinini, A. M., Gerlza, T., Adage, T. and Kungl, A. J. (2016). Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation. Neurosci Lett 626: 164-173.
  3. Piccinini, A. M., Williams, L., McCann, F. E. and Midwood, K. S. (2016). Investigating the Role of Toll-Like Receptors in Models of Arthritis. Methods Mol Biol 1390: 351-381.
  4. Piccinini, A. M. and Midwood, K. S. (2014). Illustrating the interplay between the extracellular matrix and microRNAs. Int J Exp Pathol 95(3): 158-180.
  5. Piccinini, A. M. and Midwood, K. S. (2012). Endogenous control of immunity against infection: tenascin-C regulates TLR4-mediated inflammation via microRNA-155. Cell Rep 2(4): 914-926.
  6. Page, T. H., Charles, P. J., Piccinini, A. M., Nicolaidou, V., Taylor, P. C. and Midwood, K. S. (2012). Raised circulating tenascin-C in rheumatoid arthritis. Arthritis Res Ther 14(6): R260.
  7. Adage, T., Piccinini, A. M., Falsone, A., Trinker, M., Robinson, J., Gesslbauer, B. and Kungl, A. J. (2012). Structure-based design of decoy chemokines as a way to explore the pharmacological potential of glycosaminoglycans. Br J Pharmacol 167(6): 1195-1205.
  8. Ruhmann, M., Piccinini, A. M., Kong, P. L. and Midwood, K. S. (2012). Endogenous activation of adaptive immunity: tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease. Arthritis Rheum 64(7): 2179-2190.
  9. Liehn, E. A., Piccinini, A. M., Koenen, R. R., Soehnlein, O., Adage, T., Fatu, R., Curaj, A., Popescu, A., Zernecke, A., Kungl, A. J. and Weber, C. (2010). A new monocyte chemotactic protein-1/chemokine CC motif ligand-2 competitor limiting neointima formation and myocardial ischemia/reperfusion injury in mice. J Am Coll Cardiol 56(22): 1847-1857.
  10. Piccinini, A. M. and Midwood, K. S. (2010). DAMPening inflammation by modulating TLR signalling. Mediators Inflamm 2010.
  11. Goh, F. G., Piccinini, A. M., Krausgruber, T., Udalova, I. A. and Midwood, K. S. (2010). Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation. J Immunol 184(5): 2655-2662.
  12. Piccinini, A. M., Knebl, K., Rek, A., Wildner, G., Diedrichs-Mohring, M. and Kungl, A. J. (2010). Rationally evolving MCP-1/CCL2 into a decoy protein with potent anti-inflammatory activity in vivo. J Biol Chem 285(12): 8782-8792.
  13. Midwood, K. S., Piccinini, A. M. and Sacre, S. (2009). Targeting Toll-like receptors in autoimmunity. Curr Drug Targets 10(11): 1139-1155.
  14. Midwood, K., Sacre, S., Piccinini, A. M., Inglis, J., Trebaul, A., Chan, E., Drexler, S., Sofat, N., Kashiwagi, M., Orend, G., Brennan, F. and Foxwell, B. (2009). Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med 15(7): 774-780.
  15. Koenen, R. R., von Hundelshausen, P., Nesmelova, I. V., Zernecke, A., Liehn, E. A., Sarabi, A., Kramp, B. K., Piccinini, A. M., Paludan, S. R., Kowalska, M. A., Kungl, A. J., Hackeng, T. M., Mayo, K. H. and Weber, C. (2009). Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Nat Med 15(1): 97-103.
  16. Potzinger, H., Geretti, E., Brandner, B., Wabitsch, V., Piccinini, A. M., Rek, A. and Kungl, A. J. (2006). Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs. Biochem Soc Trans 34(Pt 3): 435-437.
  17. Falsone, S. F., Gesslbauer, B., Tirk, F., Piccinini, A. M. and Kungl, A. J. (2005). A proteomic snapshot of the human heat shock protein 90 interactome. FEBS Lett 579(28): 6350-6354.
  18. Piccinini, A. M., Schmid, M. G., Pajpanova, T., Pancheva, S., Grueva, E. and Gubitz, G. (2004). Chiral separation of natural and unnatural amino acid derivatives by micro-HPLC on a Ristocetin A stationary phase. J Biochem Biophys Methods 61(1-2): 11-21.
1 Protocol published
Screening for Novel Endogenous Inflammatory Stimuli Using the Secreted Embryonic Alkaline Phosphatase NF-κB Reporter Assay
Authors:  Lorena Zuliani-Alvarez, Anna M. Piccinini and Kim S Midwood, date: 04/05/2017, view: 1520, Q&A: 0
An immune response can be activated by pathogenic stimuli, as well as endogenous danger signals, triggering the activation of pattern recognition receptors and initiating signalling cascades that lead to inflammation. This method uses THP1-BlueTM ...