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Reviewer
Kobe C. Yuen
  • Stowers Institute for Medical Research
Research focus
  • Molecular biology
  • 1 Author merit

Education

Ph.D, Stowers Institute for Medical Research, USA, 2016

Current position

Postdoctoral Research Fellow, Oncology Biomarker Development, Genentech, USA

Publications

  1. Yuen, K. C., Xu, B., Krantz, I. D. and Gerton, J. L. (2016). NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Cell Rep 14(1): 93-102.
  2. Zakari, M., Yuen, K. and Gerton, J. L. (2015). Etiology and pathogenesis of the cohesinopathies. Wiley Interdiscip Rev Dev Biol 4(5): 489-504.
  3. Aoto, K., Sandell, L. L., Butler Tjaden, N. E., Yuen, K. C., Watt, K. E., Black, B. L., Durnin, M. and Trainor, P. A. (2015). Mef2c-F10N enhancer driven beta-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells. Dev Biol 402(1): 3-16.
  4. Yuen, C. Y., Wong, S. L., Lau, C. W., Tsang, S. Y., Xu, A., Zhu, Z., Ng, C. F., Yao, X., Kong, S. K., Lee, H. K. and Huang, Y. (2012). From skeleton to cytoskeleton: osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circ Res 111(3): e55-66.
  5. Yuen, C. Y., Wong, W. T., Tian, X. Y., Wong, S. L., Lau, C. W., Yu, J., Tomlinson, B., Yao, X. and Huang, Y. (2011). Telmisartan inhibits vasoconstriction via PPARgamma-dependent expression and activation of endothelial nitric oxide synthase. Cardiovasc Res 90(1): 122-129.
1 Protocol published
Measurement of RNA-induced PKR Activation in vitro
Author:  Kobe C. Yuen, date: 03/20/2017, view: 1409, Q&A: 0
Protein kinase R (PKR) is one of the key RNA-activated sensors for innate immunity. PKR is activated by pathogenic or aberrant RNAs such as short double-stranded RNAs or those with imperfect secondary structures, as well as a reduction in the amount ...