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Coauthors
Murali Gururajan Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, USA
2 protocols

Sajni Josson Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, USA
2 protocols

Leland W.K. Chung
  • Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, USA
Contributions
  • 2 Author merit

Education

Ph.D in Pharmacology, University of Oregon Medical School

Current position

Professor of Medicine and Surgery, Director of Uro-Oncology Research Program, Cedars-Sinai Medical Center, Los Angeles, CA
Professor of Medicine, University of California at Los Angeles, CA

Publications

  1. Li, Q., Yin, L., Jones, L. W., Chu, G. C., Wu, J. B., Huang, J. M., Li, Q., You, S., Kim, J., Lu, Y. T., Mrdenovic, S., Wang, R., Freeman, M. R., Garraway, I., Lewis, M. S., Chung, L. W. and Zhau, H. E. (2016). Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells. Oncotarget 7(51): 84645-84657.
  2. Gururajan, M., Cavassani, K. A., Sievert, M., Duan, P., Lichterman, J., Huang, J. M., Smith, B., You, S., Nandana, S., Chu, G. C., Mink, S., Josson, S., Liu, C., Morello, M., Jones, L. W., Kim, J., Freeman, M. R., Bhowmick, N., Zhau, H. E., Chung, L. W. and Posadas, E. M. (2015). SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer. Oncotarget 6(42): 44072-44083.
  3. Gururajan, M., Josson, S. and Chung, L. W. (2015). Targeting the tumor-stromal-immune cell axis. Oncoscience 2(9): 743-744.
  4. Josson, S., Chung, L. W. and Gururajan, M. (2015). microRNAs and Prostate Cancer. Adv Exp Med Biol 889: 105-118.
  5. Josson, S., Gururajan, M., Sung, S. Y., Hu, P., Shao, C., Zhau, H. E., Liu, C., Lichterman, J., Duan, P., Li, Q., Rogatko, A., Posadas, E. M., Haga, C. L. and Chung, L. W. (2015). Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis. Oncogene 34(21): 2690-2699.
  6. Josson, S., Gururajan, M., Hu, P., Shao, C., Chu, G. Y., Zhau, H. E., Liu, C., Lao, K., Lu, C. L., Lu, Y. T., Lichterman, J., Nandana, S., Li, Q., Rogatko, A., Berel, D., Posadas, E. M., Fazli, L., Sareen, D. and Chung, L. W. (2014). miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer. Clin Cancer Res 20(17): 4636-4646.
  7. Wu, J. B., Shao, C., Li, X., Li, Q., Hu, P., Shi, C., Li, Y., Chen, Y. T., Yin, F., Liao, C. P., Stiles, B. L., Zhau, H. E., Shih, J. C. and Chung, L. W. (2014). Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest 124(7): 2891-2908.
  8. Chu, G. C., Zhau, H. E., Wang, R., Rogatko, A., Feng, X., Zayzafoon, M., Liu, Y., Farach-Carson, M. C., You, S., Kim, J., Freeman, M. R. and Chung, L. W. (2014). RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization. Endocr Relat Cancer 21(2): 311-326.
  9. Zhao, L., Lu, Y. T., Li, F., Wu, K., Hou, S., Yu, J., Shen, Q., Wu, D., Song, M., OuYang, W. H., Luo, Z., Lee, T., Fang, X., Shao, C., Xu, X., Garcia, M. A., Chung, L. W., Rettig, M., Tseng, H. R. and Posadas, E. M. (2013). High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing. Adv Mater 25(21): 2897-2902.
  10. Qi, J., Tripathi, M., Mishra, R., Sahgal, N., Fazli, L., Ettinger, S., Placzek, W. J., Claps, G., Chung, L. W., Bowtell, D., Gleave, M., Bhowmick, N. and Ronai, Z. A. (2013). The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell 23(3): 332-346.
  11. Jackson, R. S., 2nd, Placzek, W., Fernandez, A., Ziaee, S., Chu, C. Y., Wei, J., Stebbins, J., Kitada, S., Fritz, G., Reed, J. C., Chung, L. W., Pellecchia, M. and Bhowmick, N. A. (2012). Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. Neoplasia 14(7): 656-665.
  12. Josson, S., Nomura, T., Lin, J. T., Huang, W. C., Wu, D., Zhau, H. E., Zayzafoon, M., Weizmann, M. N., Gururajan, M. and Chung, L. W. (2011). beta2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res 71(7): 2600-2610.
  13. Huang, W. C., Zhau, H. E. and Chung, L. W. (2010). Androgen receptor survival signaling is blocked by anti-beta2-microglobulin monoclonal antibody via a MAPK/lipogenic pathway in human prostate cancer cells. J Biol Chem 285(11): 7947-7956.
  14. Yang, X., Shi, C., Tong, R., Qian, W., Zhau, H. E., Wang, R., Zhu, G., Cheng, J., Yang, V. W., Cheng, T., Henary, M., Strekowski, L. and Chung, L. W. (2010). Near IR heptamethine cyanine dye-mediated cancer imaging. Clin Cancer Res 16(10): 2833-2844.
  15. Sung, S. Y., Hsieh, C. L., Law, A., Zhau, H. E., Pathak, S., Multani, A. S., Lim, S., Coleman, I. M., Wu, L. C., Figg, W. D., Dahut, W. L., Nelson, P., Lee, J. K., Amin, M. B., Lyles, R., Johnstone, P. A., Marshall, F. F. and Chung, L. W. (2008). Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis. Cancer Res 68(23): 9996-10003.
  16. Odero-Marah, V. A., Wang, R., Chu, G., Zayzafoon, M., Xu, J., Shi, C., Marshall, F. F., Zhau, H. E. and Chung, L. W. (2008). Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells. Cell Res 18(8): 858-870.
  17. Zhau, H. Y., Chang, S. M., Chen, B. Q., Wang, Y., Zhang, H., Kao, C., Sang, Q. A., Pathak, S. J. and Chung, L. W. (1996). Androgen-repressed phenotype in human prostate cancer. Proc Natl Acad Sci U S A 93(26): 15152-15157.
  18. Thalmann, G. N., Anezinis, P. E., Chang, S. M., Zhau, H. E., Kim, E. E., Hopwood, V. L., Pathak, S., von Eschenbach, A. C. and Chung, L. W. (1994). Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer. Cancer Res 54(10): 2577-2581.
  19. Gleave, M., Hsieh, J. T., Gao, C. A., von Eschenbach, A. C. and Chung, L. W. (1991). Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts. Cancer Res 51(14): 3753-3761.
  20. Camps, J. L., Chang, S. M., Hsu, T. C., Freeman, M. R., Hong, S. J., Zhau, H. E., von Eschenbach, A. C. and Chung, L. W. (1990). Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci U S A 87(1): 75-79.
2 Protocols published
miRNA Characterization from the Extracellular Vesicles
Authors:  Sajni Josson, Murali Gururajan and Leland W.K. Chung, date: 02/20/2017, view: 1151, Q&A: 0
Cancer cells and cancer associated stromal cells co-evolve secrete extracelluar vesicles to the surrounding regions and regulate several processes involved in cancer metastasis. miRNAs have been known to be mediators of cancer progression and ...
In situ Hybridization (ISH) and Quantum Dots (QD) of miRNAs
Authors:  Sajni Josson, Murali Gururajan and Leland W.K. Chung, date: 02/20/2017, view: 1569, Q&A: 0
miRNA are short non-coding RNA which inhibit translation of mRNA. miRNA regulate several cellular processes. Certain miRNA are known to induce oncogenesis. miRNA can be measured by real-time PCR and be imaged using a combination of in situ ...