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Coauthors
Leland Chung Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, USA
2 protocols

Murali Gururajan Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, USA
2 protocols

Sajni Josson
  • Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, USA
  • 2 Author merit

Education

Ph.D in Toxicology, University of Kentucky, Lexington, KY, USA, 2006

Current position

Research Scientist, NeoStrata Company Inc.

Publications

  1. Josson, S., Chung, L. W. and Gururajan, M. (2015). microRNAs and Prostate Cancer. Adv Exp Med Biol 889: 105-118.
  2. Gururajan, M., Josson, S. and Chung, L. W. (2015). Targeting the tumor-stromal-immune cell axis. Oncoscience 2(9): 743-744.
  3. Gururajan, M., Cavassani, K. A., Sievert, M., Duan, P., Lichterman, J., Huang, J. M., Smith, B., You, S., Nandana, S., Chu, G. C., Mink, S., Josson, S., Liu, C., Morello, M., Jones, L. W., Kim, J., Freeman, M. R., Bhowmick, N., Zhau, H. E., Chung, L. W. and Posadas, E. M. (2015). SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer. Oncotarget 6(42): 44072-44083.
  4. Josson, S., Gururajan, M., Sung, S. Y., Hu, P., Shao, C., Zhau, H. E., Liu, C., Lichterman, J., Duan, P., Li, Q., Rogatko, A., Posadas, E. M., Haga, C. L. and Chung, L. W. (2015). Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis. Oncogene 34(21): 2690-2699.
  5. Josson, S., Gururajan, M., Hu, P., Shao, C., Chu, G. Y., Zhau, H. E., Liu, C., Lao, K., Lu, C. L., Lu, Y. T., Lichterman, J., Nandana, S., Li, Q., Rogatko, A., Berel, D., Posadas, E. M., Fazli, L., Sareen, D. and Chung, L. W. (2014). miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer. Clin Cancer Res 20(17): 4636-4646.
  6. Josson, S., Matsuoka, Y., Gururajan, M., Nomura, T., Huang, W. C., Yang, X., Lin, J. T., Bridgman, R., Chu, C. Y., Johnstone, P. A., Zayzafoon, M., Hu, P., Zhau, H., Berel, D., Rogatko, A. and Chung, L. W. (2013). Inhibition of beta2-microglobulin/hemochromatosis enhances radiation sensitivity by induction of iron overload in prostate cancer cells. PLoS One 8(7): e68366.
  7. Li, X., Chen, Y. T., Josson, S., Mukhopadhyay, N. K., Kim, J., Freeman, M. R. and Huang, W. C. (2013). MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. PLoS One 8(8): e70987.
  8. Nomura, T., Huang, W. C., Zhau, H. E., Josson, S., Mimata, H. and Chung, L. W. (2014). beta2-Microglobulin-mediated signaling as a target for cancer therapy. Anticancer Agents Med Chem 14(3): 343-352.
  9. Liu, C. M., Hsieh, C. L., He, Y. C., Lo, S. J., Liang, J. A., Hsieh, T. F., Josson, S., Chung, L. W., Hung, M. C. and Sung, S. Y. (2013). In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression. PLoS One 8(1): e53795.
  10. Pen, C. C., Liu, C. M., Lin, C. C., Lin, C. C., Hsieh, T. F., Josson, S., He, Y. C., Chung, L. W., Lin, K. L. and Sung, S. Y. (2012). Combined Dynamic Alterations in Urinary VEGF Levels and Tissue ADAM9 Expression as Markers for Lethal Phenotypic Progression of Prostate Cancer. Chin J Physiol 55(6): 390-397.
  11. Josson, S., Nomura, T., Lin, J. T., Huang, W. C., Wu, D., Zhau, H. E., Zayzafoon, M., Weizmann, M. N., Gururajan, M. and Chung, L. W. (2011). beta2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res 71(7): 2600-2610.
  12. Zhang, S., Wang, X., Osunkoya, A. O., Iqbal, S., Wang, Y., Chen, Z., Muller, S., Chen, Z., Josson, S., Coleman, I. M., Nelson, P. S., Wang, Y. A., Wang, R., Shin, D. M., Marshall, F. F., Kucuk, O., Chung, L. W., Zhau, H. E. and Wu, D. (2011). EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis. Oncogene 30(50): 4941-4952.
  13. Josson, S., Anderson, C. S., Sung, S. Y., Johnstone, P. A., Kubo, H., Hsieh, C. L., Arnold, R., Gururajan, M., Yates, C. and Chung, L. W. (2011). Inhibition of ADAM9 expression induces epithelial phenotypic alterations and sensitizes human prostate cancer cells to radiation and chemotherapy. Prostate 71(3): 232-240.
  14. Xu, Y., Fang, F., Zhang, J., Josson, S., St Clair, W. H. and St Clair, D. K. (2010). miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes. PLoS One 5(12): e14356.
  15. Josson, S., Sharp, S., Sung, S. Y., Johnstone, P. A., Aneja, R., Wang, R., Gururajan, M., Turner, T., Chung, L. W. and Yates, C. (2010). Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells. J Oncol 2010.
  16. Gururajan, M., Haga, C. L., Das, S., Leu, C. M., Hodson, D., Josson, S., Turner, M. and Cooper, M. D. (2010). MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol 22(7): 583-592.
  17. Josson, S., Matsuoka, Y., Chung, L. W., Zhau, H. E. and Wang, R. (2010). Tumor-stroma co-evolution in prostate cancer progression and metastasis. Semin Cell Dev Biol 21(1): 26-32.
  18. Xu, Y., Josson, S., Fang, F., Oberley, T. D., St Clair, D. K., Wan, X. S., Sun, Y., Bakthavatchalu, V., Muthuswamy, A. and St Clair, W. H. (2009). RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity. Cancer Res 69(8): 3267-3271.
  19. Xu, Y., Fang, F., St Clair, D. K., Sompol, P., Josson, S. and St Clair, W. H. (2008). SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol Cancer Ther 7(8): 2367-2376.
  20. Josson, S., Sung, S. Y., Lao, K., Chung, L. W. and Johnstone, P. A. (2008). Radiation modulation of microRNA in prostate cancer cell lines. Prostate 68(15): 1599-1606.
  21. Xu, Y., Fang, F., St Clair, D. K., Josson, S., Sompol, P., Spasojevic, I. and St Clair, W. H. (2007). Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1alpha,25-dihydroxyvitamin D(3) in prostate cancer cells. Mol Cancer Ther 6(7): 2048-2056.
  22. Josson, S., Xu, Y., Fang, F., Dhar, S. K., St Clair, D. K. and St Clair, W. H. (2006). RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells. Oncogene 25(10): 1554-1559.
2 Protocols published
miRNA Characterization from the Extracellular Vesicles
Authors:  Sajni Josson, Murali Gururajan and Leland W.K. Chung, date: 02/20/2017, view: 1462, Q&A: 0
Cancer cells and cancer associated stromal cells co-evolve secrete extracellular vesicles to the surrounding regions and regulate several processes involved in cancer metastasis. miRNAs have been known to be mediators of cancer progression and ...
In situ Hybridization (ISH) and Quantum Dots (QD) of miRNAs
Authors:  Sajni Josson, Murali Gururajan and Leland W.K. Chung, date: 02/20/2017, view: 1923, Q&A: 0
miRNA are short non-coding RNA which inhibit translation of mRNA. miRNA regulate several cellular processes. Certain miRNA are known to induce oncogenesis. miRNA can be measured by real-time PCR and be imaged using a combination of in situ ...