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Coauthors
Catharina Svanborg Department of Microbiology, Immunology and Glycobiology (MIG), Institute of Laboratory Medicine, Lund University, Sweden
1 protocol

Andreas Wieser Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität, Germany
1 protocol

Manoj Puthia Department of Microbiology, Immunology and Glycobiology (MIG), Institute of Laboratory Medicine, Lund University, Sweden
1 protocol

Anna Waldhuber Molekulare Pädiatrie, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität, Germany
1 protocol

Thomas Miethke
  • Institute of Medical Microbiology and Hygiene, Medical Faculty of Mannheim, University of Heidelberg, Germany
Contributions
  • 1 Author merit

Education

M.D, Technische Universität München, 1985

Current position

Professor and Chair, Medical Microbiology and Hygiene, Medical Faculty of Mannheim, University of Heidelberg, Germany

Publications

  1. Ambite, I., Puthia, M., Nagy, K., Cafaro, C., Nadeem, A., Butler, D. S., Rydstrom, G., Filenko, N. A., Wullt, B., Miethke, T. and Svanborg, C. (2016). Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets. PLoS Pathog 12(10): e1005848.
  2. Boch, T., Buchheidt, D., Spiess, B., Miethke, T., Hofmann, W. K. and Reinwald, M. (2016). Direct comparison of galactomannan performance in concurrent serum and bronchoalveolar lavage samples in immunocompromised patients at risk for invasive pulmonary aspergillosis. Mycoses 59(2): 80-85.
  3. Waldhuber, A., Puthia, M., Wieser, A., Cirl, C., Durr, S., Neumann-Pfeifer, S., Albrecht, S., Rommler, F., Muller, T., Zheng, Y., Schubert, S., Gross, O., Svanborg, C. and Miethke, T. (2016). Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation. J Clin Invest 126(7): 2425-2436.
  4. Burrer, A., Findeisen, P., Jager, E., Ghebremedhin, B., Grundt, A., Ahmad-Nejad, P., Miethke, T. and Neumaier, M. (2015). Rapid detection of cefotaxime-resistant Escherichia coli by LC-MS. Int J Med Microbiol 305(8): 860-864.
  5. Rommler, F., Hammel, M., Waldhuber, A., Muller, T., Jurk, M., Uhlmann, E., Wagner, H., Vollmer, J. and Miethke, T. (2015). Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One 10(2): e0116703.
  6. Hildebrand, D., Bode, K. A., Riess, D., Cerny, D., Waldhuber, A., Rommler, F., Strack, J., Korten, S., Orth, J. H., Miethke, T., Heeg, K. and Kubatzky, K. F. (2014). Granzyme A produces bioactive IL-1beta through a nonapoptotic inflammasome-independent pathway. Cell Rep 9(3): 910-917.
  7. Spiess, B., Postina, P., Reinwald, M., Cornely, O. A., Hamprecht, A., Hoenigl, M., Lass-Florl, C., Rath, P. M., Steinmann, J., Miethke, T., Lauten, M., Will, S., Merker, N., Hofmann, W. K. and Buchheidt, D. (2014). Incidence of Cyp51 A key mutations in Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995-2013. PLoS One 9(7): e103113.
  8. Traves, P. G., Pimentel-Santillana, M., Rico, D., Rodriguez, N., Miethke, T., Castrillo, A., Theodorakis, E. A., Martin-Sanz, P., Palladino, M. A. and Bosca, L. (2014). Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110gamma/delta subunits and inhibition of NF-kappaB. Chem Biol 21(8): 955-966.
  9. Snyder, G. A., Deredge, D., Waldhuber, A., Fresquez, T., Wilkins, D. Z., Smith, P. T., Durr, S., Cirl, C., Jiang, J., Jennings, W., Luchetti, T., Snyder, N., Sundberg, E. J., Wintrode, P., Miethke, T. and Xiao, T. S. (2014). Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J Biol Chem 289(2): 669-679.
  10. Prodinger, P. M., Pilge, H., Banke, I. J., Burklein, D., Gradinger, R., Miethke, T. and Holzapfel, B. M. (2013). Acute osteomyelitis of the humerus mimicking malignancy: Streptococcus pneumoniae as exceptional pathogen in an immunocompetent adult. BMC Infect Dis 13: 266.
  11. Rommler, F., Jurk, M., Uhlmann, E., Hammel, M., Waldhuber, A., Pfeiffer, L., Wagner, H., Vollmer, J. and Miethke, T. (2013). Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol 191(6): 3240-3253.
  12. Snyder, G. A., Cirl, C., Jiang, J., Chen, K., Waldhuber, A., Smith, P., Rommler, F., Snyder, N., Fresquez, T., Durr, S., Tjandra, N., Miethke, T. and Xiao, T. S. (2013). Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proc Natl Acad Sci U S A 110(17): 6985-6990.
  13. Grundt, A., Findeisen, P., Miethke, T., Jager, E., Ahmad-Nejad, P. and Neumaier, M. (2012). Rapid detection of ampicillin resistance in Escherichia coli by quantitative mass spectrometry. J Clin Microbiol 50(5): 1727-1729.
  14. Mackern Oberti, J. P., Breser, M. L., Nunez, N., Maccioni, M., Rodriguez, N., Wantia, N., Ertl, T., Miethke, T. and Rivero, V. E. (2011). Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells. Reproduction 142(3): 427-437.
  15. Gradl, G., Horn, C., Postl, L. K., Miethke, T. and Gollwitzer, H. (2011). Antibiotic prophylaxis in primary and revision hip arthroplasty: what is the evidence?. Orthopade 40(6): 520-527.
  16. Mackern-Oberti, J. P., Maccioni, M., Breser, M. L., Eley, A., Miethke, T. and Rivero, V. E. (2011). Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures. J Med Microbiol 60(Pt 3): 307-316.
  17. Yadav, M., Zhang, J., Fischer, H., Huang, W., Lutay, N., Cirl, C., Lum, J., Miethke, T. and Svanborg, C. (2010). Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence. PLoS Pathog 6(9): e1001120.
  18. Seifert, H., Dalhoff, A. and Group, P. S. (2010). German multicentre survey of the antibiotic susceptibility of Bacteroides fragilis group and Prevotella species isolated from intra-abdominal infections: results from the PRISMA study. J Antimicrob Chemother 65(11): 2405-2410.
  19. Rodriguez, N., Dietrich, H., Mossbrugger, I., Weintz, G., Scheller, J., Hammer, M., Quintanilla-Martinez, L., Rose-John, S., Miethke, T. and Lang, R. (2010). Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6. J Leukoc Biol 88(3): 579-587.
  20. Peschel, G., Kernschmidt, L., Cirl, C., Wantia, N., Ertl, T., Durr, S., Wagner, H., Miethke, T. and Rodriguez, N. (2010). Chlamydophila pneumoniae downregulates MHC-class II expression by two cell type-specific mechanisms. Mol Microbiol 76(3): 648-661.
1 Protocol published
Analysis of the Virulence of Uropathogenic Escherichia coli Strain CFT073 in the Murine Urinary Tract
Authors:  Anna Waldhuber, Manoj Puthia, Andreas Wieser, Catharina Svanborg and Thomas Miethke , date: 02/05/2017, view: 2003, Q&A: 0
This urinary tract infection model was used to monitor the efficacy of a new virulence factor of the uropathogenic Escherichia coli strain CFT073 in vivo. The new virulence factor which we designated TIR-containing protein C (TcpC) ...