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Coauthors
Sebastian Amigorena Institute Curie, PSL Research University, INSERM U932, France
2 protocols

Fiorella Kotsias Institute Curie, PSL Research University, INSERM U932, France
2 protocols

Andrés Alloatti IDICER
2 protocols

Anne-Marie Pauwels VIB Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, Belgium
1 protocol

Eik Hoffmann
  • Institute Curie, PSL Research University, INSERM U932, France
Contributions
  • 2 Author merit

Education

Ph.D. in Cell Biology, Institute of Biological Sciences, University of Rostock, Germany, 2008

Current Position

Senior postdoc in the group of Rudi Beyaert, VIB – Inflammation Research Center, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium

Publications

  1. van de Laar, L., Saelens, W., De Prijck, S., Martens, L., Scott, C. L., Van Isterdael, G., Hoffmann, E., Beyaert, R., Saeys, Y., Lambrecht, B. N. and Guilliams, M. (2016). Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages. Immunity 44(4): 755-768.

  2. Alloatti, A., Kotsias, F., Pauwels, A. M., Carpier, J. M., Jouve, M., Timmerman, E., Pace, L., Vargas, P., Maurin, M., Gehrmann, U., Joannas, L., Vivar, O. I., Lennon-Dumenil, A. M., Savina, A., Gevaert, K., Beyaert, R., Hoffmann, E. and Amigorena, S. (2015). Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens. Immunity 43(6): 1087-1100.
  3. Osorio, F., Tavernier, S. J., Hoffmann, E., Saeys, Y., Martens, L., Vetters, J., Delrue, I., De Rycke, R., Parthoens, E., Pouliot, P., Iwawaki, T., Janssens, S. and Lambrecht, B. N. (2014). The unfolded-protein-response sensor IRE-1alpha regulates the function of CD8alpha+ dendritic cells. Nat Immunol 15(3): 248-257.
  4. Kotsias, F., Hoffmann, E., Amigorena, S. and Savina, A. (2013). Reactive oxygen species production in the phagosome: impact on antigen presentation in dendritic cells. Antioxid Redox Signal 18(6): 714-729.
  5. Hoffmann, E., Kotsias, F., Visentin, G., Bruhns, P., Savina, A. and Amigorena, S. (2012). Autonomous phagosomal degradation and antigen presentation in dendritic cells. Proc Natl Acad Sci U S A 109(36): 14556-14561.
  6. Bhattacharya, K., Hoffmann, E., Schins, R. F., Boertz, J., Prantl, E. M., Alink, G. M., Byrne, H. J., Kuhlbusch, T. A., Rahman, Q., Wiggers, H., Schulz, C. and Dopp, E. (2012). Comparison of micro- and nanoscale Fe+3-containing (hematite) particles for their toxicological properties in human lung cells in vitro. Toxicol Sci 126(1):173-82.
  7. Gopaldass, N., Patel, D., Kratzke, R., Dieckmann, R., Hausherr, S., Hagedorn, M., Monroy, R., Kruger, J., Neuhaus, E. M., Hoffmann, E., Hille, K., Kuznetsov, S. A. and Soldati, T. (2012). Dynamin A, Myosin IB and Abp1 couple phagosome maturation to F-actin binding. Traffic 13(1): 120-130.
  8. Marion, S., Hoffmann, E., Holzer, D., Le Clainche, C., Martin, M., Sachse, M., Ganeva, I., Mangeat, P. and Griffiths, G. (2011). Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion. Traffic 12(4): 421-437.
  9. Hoffmann, E., Marion, S., Mishra, B. B., John, M., Kratzke, R., Ahmad, S. F., Holzer, D., Anand, P. K., Weiss, D. G., Griffiths, G. and Kuznetsov, S. A. (2010). Initial receptor-ligand interactions modulate gene expression and phagosomal properties during both early and late stages of phagocytosis. Eur J Cell Biol 89(9): 693-704.
  10. Bhattacharya, K., Davoren, M., Boertz, J., Schins, R. P., Hoffmann, E. and Dopp, E. (2009). Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells. Part Fibre Toxicol 6: 17.
  11. Kuehnel, M. P., Reiss, M., Anand, P. K., Treede, I., Holzer, D., Hoffmann, E., Klapperstueck, M., Steinberg, T. H., Markwardt, F. and Griffiths, G. (2009). Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation. J Cell Sci 122(Pt 4): 505-512.
  12. Schwarz, R., Liang, C., Kaleta, C., Kuhnel, M., Hoffmann, E., Kuznetsov, S., Hecker, M., Griffiths, G., Schuster, S. and Dandekar, T. (2007). Integrated network reconstruction, visualization and analysis using YANAsquare. BMC Bioinformatics 8: 313.
  13. Geh, S., Yucel, R., Duffin, R., Albrecht, C., Borm, P. J., Armbruster, L., Raulf-Heimsoth, M., Bruning, T., Hoffmann, E., Rettenmeier, A. W. and Dopp, E. (2006). Cellular uptake and cytotoxic potential of respirable bentonite particles with different quartz contents and chemical modifications in human lung fibroblasts. Arch Toxicol 80(2): 98-106.
  14. Roder, A., Hoffmann, E., Hagemann, M. and Berg, G. (2005). Synthesis of the compatible solutes glucosylglycerol and trehalose by salt-stressed cells of Stenotrophomonas strains. FEMS Microbiol Lett 243(1): 219-226.
  15. Burmeister, B., Schwerdtle, T., Poser, I., Hoffmann, E., Hartwig, A., Muller, W. U., Rettenmeier, A. W., Seemayer, N. H. and Dopp, E. (2004). Effects of asbestos on initiation of DNA damage, induction of DNA-strand breaks, P53-expression and apoptosis in primary, SV40-transformed and malignant human mesothelial cells. Mutat Res 558(1-2): 81-92.
2 Protocols published
Evaluation of Cross-presentation in Bone Marrow-derived Dendritic Cells in vitro and Splenic Dendritic Cells ex vivo Using Antigen-coated Beads
Authors:  Andrés Alloatti, Fiorella Kotsias, Eik Hoffmann and Sebastian Amigorena, date: 11/20/2016, view: 2254, Q&A: 0
Antigen presentation by MHC class I molecules, also referred to as cross-presentation, elicits cytotoxic immune responses. In particular, dendritic cells (DC) are the most proficient cross-presenting cells, since they have developed unique means to ...
Analysis of Phagosomal Antigen Degradation by Flow Organellocytometry
Professional phagocytes internalize self and non-self particles by phagocytosis to initiate innate immune responses. After internalization, the formed phagosome matures through fusion and fission events with endosomes and lysosomes to obtain a more ...