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Coauthors
Guo Chen Division of Cancer Biology, Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, USA
1 protocol

Dongsheng Wang Division of Cancer Biology, Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, USA
1 protocol

Dongkyoo Park Emory University School of Medicine and Winship Cancer Institute of Emory University
1 protocol

Xingming Deng
  • Division of Cancer Biology, Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, USA
Contributions
  • 1 Author merit

Education

M.D in Medicine, Hunan Medical University, 1985

Current Position

Associate Professor in the Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA

Publications (since 2013)

  1. Owonikoko, T. K., Zhang, G., Kim, H. S., Stinson, R. M., Bechara, R., Zhang, C., Chen, Z., Saba, N. F., Pakkala, S., Pillai, R., Deng, X., Sun, S. Y., Rossi, M. R., Sica, G. L., Ramalingam, S. S. and Khuri, F. R. (2016). Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer. J Transl Med 14(1): 111.

  2. Deng, J., Park, D., Wang, M., Nooka, A., Deng, Q., Matulis, S., Kaufman, J., Lonial, S., Boise, L. H., Galipeau, J. and Deng, X. (2016). BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth. Oncotarget 7(19): 27753-27763.

  3. Chowdry, R. P., Sica, G. L., Kim, S., Chen, Z., Goodman, A., Alexis, D., Deng, X. and Owonikoko, T. K. (2016). Phosphorylated Bcl-2 and Mcl-1 as prognostic markers in small cell lung cancer. Oncotarget.

  4. Zhang, H., Head, P. E., Daddacha, W., Park, S. H., Li, X., Pan, Y., Madden, M. Z., Duong, D. M., Xie, M., Yu, B., Warren, M. D., Liu, E. A., Dhere, V. R., Li, C., Pradilla, I., Torres, M. A., Wang, Y., Dynan, W. S., Doetsch, P. W., Deng, X., Seyfried, N. T., Gius, D. and Yu, D. S. (2016). ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell Rep 14(6): 1435-1447.

  5. Chen, G. and Deng, X. (2015). Targeting Bcl2 in cancer. Oncoscience 2(10): 813-814.

  6. Xie, M., Doetsch, P. W. and Deng, X. (2015). Bcl2 inhibition of mitochondrial DNA repair. BMC Cancer 15: 586.

  7. Koo, J., Yue, P., Deng, X., Khuri, F. R. and Sun, S. Y. (2015). mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation. Mol Cell Biol 35(13): 2344-2355.

  8. Han, B., Park, D., Li, R., Xie, M., Owonikoko, T. K., Zhang, G., Sica, G. L., Ding, C., Zhou, J., Magis, A. T., Chen, Z. G., Shin, D. M., Ramalingam, S. S., Khuri, F. R., Curran, W. J. and Deng, X. (2015). Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell 27(6): 852-863.

  9. Owonikoko, T. K., Ramalingam, S. S., Miller, D. L., Force, S. D., Sica, G. L., Mendel, J., Chen, Z., Rogatko, A., Tighiouart, M., Harvey, R. D., Kim, S., Saba, N. F., Pickens, A., Behera, M., Fu, R. W., Rossi, M. R., Auffermann, W. F., Torres, W. E., Bechara, R., Deng, X., Sun, S. Y., Fu, H., Gal, A. A. and Khuri, F. R. (2015). A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer. Clin Cancer Res 21(8): 1859-1868.

  10. Xie, M., Park, D., You, S., Li, R., Owonikoko, T. K., Wang, Y., Doetsch, P. W. and Deng, X. (2015). Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation. Nucleic Acids Res 43(2): 960-972.

  11. Xin, M., Li, R., Xie, M., Park, D., Owonikoko, T. K., Sica, G. L., Corsino, P. E., Zhou, J., Ding, C., White, M. A., Magis, A. T., Ramalingam, S. S., Curran, W. J., Khuri, F. R. and Deng, X. (2014). Small-molecule Bax agonists for cancer therapy. Nat Commun 5: 4935.

  12. Wang, H., Wang, X., Chen, G., Zhang, X., Tang, X., Park, D., Cucinotta, F. A., Yu, D. S., Deng, X., Dynan, W. S., Doetsch, P. W. and Wang, Y. (2014). Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. J Biol Chem 289(44): 30635-30644.

  13. Owonikoko, T. K., Zhang, G., Deng, X., Rossi, M. R., Switchenko, J. M., Doho, G. H., Chen, Z., Kim, S., Strychor, S., Christner, S. M., Beumer, J., Li, C., Yue, P., Chen, A., Sica, G. L., Ramalingam, S. S., Kowalski, J., Khuri, F. R. and Sun, S. Y. (2014). Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer. Cancer Med 3(6): 1579-1594.

  14. Higgins, K. A., Park, D., Lee, G. Y., Curran, W. J. and Deng, X. (2014). Exercise-induced lung cancer regression: mechanistic findings from a mouse model. Cancer 120(21): 3302-3310.

  15. Xiao, L., Hu, Z. Y., Dong, X., Tan, Z., Li, W., Tang, M., Chen, L., Yang, L., Tao, Y., Jiang, Y., Li, J., Yi, B., Li, B., Fan, S., You, S., Deng, X., Hu, F., Feng, L., Bode, A. M., Dong, Z., Sun, L. Q. and Cao, Y. (2014). Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene 33(37): 4568-4578.

  16. Wang, B., Xie, M., Li, R., Owonikoko, T. K., Ramalingam, S. S., Khuri, F. R., Curran, W. J., Wang, Y. and Deng, X. (2014). Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis. Cell Death Differ 21(7): 1160-1169.

  17. Xie, M., Yen, Y., Owonikoko, T. K., Ramalingam, S. S., Khuri, F. R., Curran, W. J., Doetsch, P. W. and Deng, X. (2014). Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase. Cancer Res 74(1): 212-223.

  18. You, S., Li, R., Park, D., Xie, M., Sica, G. L., Cao, Y., Xiao, Z. Q. and Deng, X. (2014). Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. Mol Cancer Ther 13(3): 606-616.

  19. Ren, H., Koo, J., Guan, B., Yue, P., Deng, X., Chen, M., Khuri, F. R. and Sun, S. Y. (2013). The E3 ubiquitin ligases beta-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Mol Cancer 12: 146.

  20. Li, R., You, S., Hu, Z., Chen, Z. G., Sica, G. L., Khuri, F. R., Curran, W. J., Shin, D. M. and Deng, X. (2013). Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PLoS One 8(9): e74670.

  21. Li, R., Hu, Z., Sun, S. Y., Chen, Z. G., Owonikoko, T. K., Sica, G. L., Ramalingam, S. S., Curran, W. J., Khuri, F. R. and Deng, X. (2013). Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther 12(10): 2200-2212.

  22. Park, D., Magis, A. T., Li, R., Owonikoko, T. K., Sica, G. L., Sun, S. Y., Ramalingam, S. S., Khuri, F. R., Curran, W. J. and Deng, X. (2013). Novel small-molecule inhibitors of Bcl-XL to treat lung cancer. Cancer Res 73(17): 5485-5496.

  23. Ma, X., Xu, Z., Yang, L., Xiao, L., Tang, M., Lu, J., Xu, S., Tang, Y., Wen, X., Deng, X., Sun, L. and Cao, Y. (2013). EBV-LMP1-targeted DNAzyme induces DNA damage and causes cell cycle arrest in LMP1-positive nasopharyngeal carcinoma cells. Int J Oncol 43(5): 1541-1548.

  24. Zeng, G. Q., Yi, H., Zhang, P. F., Li, X. H., Hu, R., Li, M. Y., Li, C., Qu, J. Q., Deng, X. and Xiao, Z. Q. (2013). The function and significance of SELENBP1 downregulation in human bronchial epithelial carcinogenic process. PLoS One 8(8): e71865.

  25. Hagen, K. R., Zeng, X., Lee, M. Y., Tucker Kahn, S., Harrison Pitner, M. K., Zaky, S. S., Liu, Y., O'Regan, R. M., Deng, X. and Saavedra, H. I. (2013). Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis. Cell Div 8(1): 10.

  26. Rahman, M. A., Amin, A. R., Wang, D., Koenig, L., Nannapaneni, S., Chen, Z., Wang, Z., Sica, G., Deng, X., Chen, Z. G. and Shin, D. M. (2013). RRM2 regulates Bcl-2 in head and neck and lung cancers: a potential target for cancer therapy. Clin Cancer Res 19(13): 3416-3428.

  27. Ren, H., Zhao, L., Li, Y., Yue, P., Deng, X., Owonikoko, T. K., Chen, M., Khuri, F. R. and Sun, S. Y. (2013). The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis. Cancer Lett 338(2): 229-238.

  28. Li, Y., Wang, X., Yue, P., Tao, H., Ramalingam, S. S., Owonikoko, T. K., Deng, X., Wang, Y., Fu, H., Khuri, F. R. and Sun, S. Y. (2013). Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation. J Biol Chem 288(19): 13215-13224.

1 Protocol published
Establishment of Patient-Derived Xenografts in Mice
Authors:  Dongkyoo Park, Dongsheng Wang, Guo Chen and Xingming Deng, date: 11/20/2016, view: 2656, Q&A: 0
Patient-derived xenograft (PDX) models for cancer research have recently attracted considerable attention in both the academy and industry (Hidalgo et al., 2014; Wilding and Bodmer, 2014). PDX models have been developed from different tumor ...