Education

Ph.D, Joint degree between European Molecular Biology Laboratory, Hamburg, Germany and Faculty of Science and Technology, Institute for Molecular Biology, Aarhus University, Denmark, 2005

Current position

Group Leader/principle investigator. NCMM, Oslo University, Norway

Publications (since 2010)

1. Bjerregaard-Andersen, K., Ostensen, E., Scott, J. D., Tasken, K. and Morth, J. P. (2016). Malonate in the nucleotide-binding site traps human AKAP18gamma/delta in a novel conformational state. Acta Crystallogr F Struct Biol Commun 72(Pt 8): 591-597.

2. Gerner, L., Munack, S., Temmerman, K., Lawrence-Dorner, A. M., Besir, H., Wilmanns, M., Jensen, J. K., Thiede, B., Mills, I. G. and Morth, J. P. (2016). Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli. Data Brief 8: 733-740.

3. Gerner, L., Munack, S., Temmerman, K., Lawrence-Dorner, A. M., Besir, H., Wilmanns, M., Jensen, J. K., Thiede, B., Mills, I. G. and Morth, J. P. (2016). Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2. Biochem Biophys Res Commun 476(2): 102-107.

4. Hong, Z., De Meulemeester, L., Jacobi, A., Pedersen, J. S., Morth, J. P., Andreasen, P. A. and Jensen, J. K. (2016). Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN. J Biol Chem 291(27): 14340-14355.

5. Leo, J. C., Oberhettinger, P., Yoshimoto, S., Udatha, D. B., Morth, J. P., Schutz, M., Hori, K. and Linke, D. (2016). Secretion of the Intimin Passenger Domain Is Driven by Protein Folding. J Biol Chem 291(38): 20096-20112.

6. Subramani, S., Perdreau-Dahl, H. and Morth, J. P. (2016). The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro. Elife 5.

7. Ricanek, P., Lunde, L. K., Frye, S. A., Stoen, M., Nygard, S., Morth, J. P., Rydning, A., Vatn, M. H., Amiry-Moghaddam, M. and Tonjum, T. (2015). Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease. Clin Exp Gastroenterol 8: 49-67.

8. Sommer, T., Bjerregaard-Andersen, K., Simensen, S. M., Jensen, J. K., Jochimsen, B., Riss, P. J., Etzerodt, M. and Morth, J. P. (2015). Enzymatic detection and quantification assay of isatin, a putative stress biomarker in blood. ACS Chem Neurosci 6(8): 1353-1360.

9. Bjerregaard-Andersen, K., Sommer, T., Jensen, J. K., Jochimsen, B., Etzerodt, M. and Morth, J. P. (2014). A proton wire and water channel revealed in the crystal structure of isatin hydrolase. J Biol Chem 289(31): 21351-21359.

10. Ostenfeld, M. S., Jeppesen, D. K., Laurberg, J. R., Boysen, A. T., Bramsen, J. B., Primdal-Bengtson, B., Hendrix, A., Lamy, P., Dagnaes-Hansen, F., Rasmussen, M. H., Bui, K. H., Fristrup, N., Christensen, E. I., Nordentoft, I., Morth, J. P., Jensen, J. B., Pedersen, J. S., Beck, M., Theodorescu, D., Borre, M., Howard, K. A., Dyrskjot, L. and Orntoft, T. F. (2014). Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties. Cancer Res 74(20): 5758-5771.

11. Bjerregaard-Andersen, K., Perdreau-Dahl, H., Guldsten, H., Praetorius, J., Jensen, J. K. and Morth, J. P. (2013). The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening. Front Physiol 4: 320.

12. Bublitz, M., Musgaard, M., Poulsen, H., Thogersen, L., Olesen, C., Schiott, B., Morth, J. P., Moller, J. V. and Nissen, P. (2013). Ion pathways in the sarcoplasmic reticulum Ca2+-ATPase. J Biol Chem 288(15): 10759-10765.

13. Groftehauge, M. K., Therkelsen, M. O., Taaning, R., Skrydstrup, T., Morth, J. P. and Nissen, P. (2013). Identifying ligand-binding hot spots in proteins using brominated fragments. Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 9): 1060-1065.

14. Kotsubei, A., Gorgel, M., Morth, J. P., Nissen, P. and Andersen, J. L. (2013). Probing determinants of cyclopiazonic acid sensitivity of bacterial Ca2+-ATPases. FEBS J 280(21): 5441-5449.

15. Nagelhus, E. A., Amiry-Moghaddam, M., Bergersen, L. H., Bjaalie, J. G., Eriksson, J., Gundersen, V., Leergaard, T. B., Morth, J. P., Storm-Mathisen, J., Torp, R., Walhovd, K. B. and Tonjum, T. (2013). The glia doctrine: addressing the role of glial cells in healthy brain ageing. Mech Ageing Dev 134(10): 449-459.

16. Voronkov, A., Holsworth, D. D., Waaler, J., Wilson, S. R., Ekblad, B., Perdreau-Dahl, H., Dinh, H., Drewes, G., Hopf, C., Morth, J. P. and Krauss, S. (2013). Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor. J Med Chem 56(7): 3012-3023.

17. Hein, K. L., Nissen, P. and Morth, J. P. (2012). Purification, crystallization and preliminary crystallographic studies of a PacL homologue from Listeria monocytogenes. Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 4): 424-427.

18. Preu, J., Panjikar, S., Morth, P., Jaiswal, R., Karunakar, P. and Tucker, P. A. (2012). The sensor region of the ubiquitous cytosolic sensor kinase, PdtaS, contains PAS and GAF domain sensing modules. J Struct Biol 177(2): 498-505.

19. Andersen, J. L., Gourdon, P., Moller, J. V., Morth, J. P. and Nissen, P. (2011). Crystallization and preliminary structural analysis of the Listeria monocytogenes Ca(2+)-ATPase LMCA1. Acta Crystallogr Sect F Struct Biol Cryst Commun 67(Pt 6): 718-722.

20. Arnou, B., Montigny, C., Morth, J. P., Nissen, P., Jaxel, C., Moller, J. V. and Maire, M. (2011). The Plasmodium falciparum Ca(2+)-ATPase PfATP6: insensitive to artemisinin, but a potential drug target. Biochem Soc Trans 39(3): 823-831.

21. Bublitz, M., Morth, J. P. and Nissen, P. (2011). P-type ATPases at a glance. J Cell Sci 124(Pt 15): 2515-2519.

22. Faxen, K., Andersen, J. L., Gourdon, P., Fedosova, N., Morth, J. P., Nissen, P. and Moller, J. V. (2011). Characterization of a Listeria monocytogenes Ca(2+) pump: a SERCA-type ATPase with only one Ca(2+)-binding site. J Biol Chem 286(2): 1609-1617.

23. Gourdon, P., Liu, X. Y., Skjorringe, T., Morth, J. P., Moller, L. B., Pedersen, B. P. and Nissen, P. (2011). Crystal structure of a copper-transporting PIB-type ATPase. Nature 475(7354): 59-64.

24. Jensen, J. K., Thompson, L. C., Bucci, J. C., Nissen, P., Gettins, P. G., Peterson, C. B., Andreasen, P. A. and Morth, J. P. (2011). Crystal structure of plasminogen activator inhibitor-1 in an active conformation with normal thermodynamic stability. J Biol Chem 286(34): 29709-29717.

25. Morth, J. P., Pedersen, B. P., Buch-Pedersen, M. J., Andersen, J. P., Vilsen, B., Palmgren, M. G. and Nissen, P. (2011). A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps. Nat Rev Mol Cell Biol 12(1): 60-70.

26. Bublitz, M., Poulsen, H., Morth, J. P. and Nissen, P. (2010). In and out of the cation pumps: P-type ATPase structure revisited. Curr Opin Struct Biol 20(4): 431-439.

27. Hein, K. L., Kragh-Hansen, U., Morth, J. P., Jeppesen, M. D., Otzen, D., Moller, J. V. and Nissen, P. (2010). Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin. J Struct Biol 171(3): 353-360.

28. Pedersen, B. P., Morth, J. P. and Nissen, P. (2010). Structure determination using poorly diffracting membrane-protein crystals: the H+-ATPase and Na+,K+-ATPase case history. Acta Crystallogr D Biol Crystallogr 66(Pt 3): 309-313.

29. Poulsen, H., Khandelia, H., Morth, J. P., Bublitz, M., Mouritsen, O. G., Egebjerg, J. and Nissen, P. (2010). Neurological disease mutations compromise a C-terminal ion pathway in the na(+)/K(+)-ATPase. Nature 467 (2010) 99-102.

30. Poulsen, H., Morth, P., Egebjerg, J. and Nissen, P. (2010). Phosphorylation of the Na+,K+-ATPase and the H+,K+-ATPase. FEBS Lett 584(12): 2589-2595.