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Coauthors
Joan Cadillac Animal Resources Program, the University of Alabama at Birmingham, USA, USA,
1 protocol

Daniel Kennedy Department of Genetics, the University of Alabama at Birmingham, USA, USA,
1 protocol

Larry Johnson UAB, AL
2 protocols

Laura Lambert The University of Alabama at Birmingham
2 protocols

Robert A. Kesterson
  • Genetics, UAB, USA
  • 2 Author merit

Education

Ph.D. in Cell Biology from Baylor College of Medicine, 1993

Current position

Director, Transgenic & Genetically Engineered Models (TGEMs) Facility University of Alabama at Birmingham

Publications

  1. Toonen, J. A., Anastasaki, C., Smithson, L. J., Gianino, S. M., Li, K., Kesterson, R. A. and Gutmann, D. H. (2016). NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1. Hum Mol Genet 25(9): 1703-1713.

  2. Li, K., Turner, A. N., Chen, M., Brosius, S. N., Schoeb, T. R., Messiaen, L. M., Bedwell, D. M., Zinn, K. R., Anastasaki, C., Gutmann, D. H., Korf, B. R. and Kesterson, R. A. (2016). Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I. Dis Model Mech 9(7): 759-767.

  3. Lewis, W. R., Malarkey, E. B., Tritschler, D., Bower, R., Pasek, R. C., Porath, J. D., Birket, S. E., Saunier, S., Antignac, C., Knowles, M. R., Leigh, M. W., Zariwala, M. A., Challa, A. K., Kesterson, R. A., Rowe, S. M., Drummond, I. A., Parant, J. M., Hildebrandt, F., Porter, M. E., Yoder, B. K. and Berbari, N. F. (2016). Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. PLoS Genet 12(7): e1006220.

  4. Challa, A. K., Boitet, E. R., Turner, A. N., Johnson, L. W., Kennedy, D., Downs, E. R., Hymel, K. M., Gross, A. K. and Kesterson, R. A. (2016). Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes. PLoS One 11(5): e0155812.

  5. Feeley, K. P., Bray, A. W., Westbrook, D. G., Johnson, L. W., Kesterson, R. A., Ballinger, S. W. and Welch, D. R. (2015). Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential. Cancer Res 75(20): 4429-4436.

  6. O'Connor, A. K., Malarkey, E. B., Berbari, N. F., Croyle, M. J., Haycraft, C. J., Bell, P. D., Hohenstein, P., Kesterson, R. A. and Yoder, B. K. (2013). An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue. Cilia 2(1): 8.

  7. Fetterman, J. L., Zelickson, B. R., Johnson, L. W., Moellering, D. R., Westbrook, D. G., Pompilius, M., Sammy, M. J., Johnson, M., Dunham-Snary, K. J., Cao, X., Bradley, W. E., Zhang, J., Wei, C. C., Chacko, B., Schurr, T. G., Kesterson, R. A., Dell'italia, L. J., Darley-Usmar, V. M., Welch, D. R. and Ballinger, S. W. (2013). Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload. Biochem J 455(2): 157-167.

  8. Kesterson, R. A., Berbari, N. F., Pasek, R. C. and Yoder, B. K. (2009). Utilization of conditional alleles to study the role of the primary cilium in obesity. Methods Cell Biol 94: 163-179.

  9. Davenport, J. R., Watts, A. J., Roper, V. C., Croyle, M. J., van Groen, T., Wyss, J. M., Nagy, T. R., Kesterson, R. A. and Yoder, B. K. (2007). Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol 17(18): 1586-1594.

  10. Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S. E., Hill, J. K., Pantely, G. A., Hohimer, A. R., Hatton, D. C., Phillips, T. J., Finn, D. A., Low, M. J., Rittenberg, M. B., Stenzel, P. and Stenzel-Poore, M. P. (2000). Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet 24(4): 403-409.

  11. Kesterson, R. A., Huszar, D., Lynch, C. A., Simerly, R. B. and Cone, R. D. (1997). Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol Endocrinol 11(5): 630-637.

  12. Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., Smith, F. J., Campfield, L. A., Burn, P. and Lee, F. (1997). Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88(1): 131-141.

  13. Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J. and Cone, R. D. (1997). Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385(6612): 165-168.

  14. Hughes, M. R., Malloy, P. J., Kieback, D. G., Kesterson, R. A., Pike, J. W., Feldman, D. and O'Malley, B. W. (1988). Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 242(4886): 1702-1705.

2 Protocols published
Improved Oviduct Transfer Surgery for Genetically Modified Rat Production
Rat embryo transfer surgeries are becoming more common with targeted nucleases increasing the demand for rat models. This protocol details pre-surgical preparation, improved surgical techniques for placing embryos into the oviduct, and post-surgical ...
Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer
The mitochondrial paradigm for common disease proposes that mitochondrial DNA (mtDNA) sequence variation can contribute to disease susceptibility and progression. To test this concept, we developed the Mitochondrial-nuclear eXchange (MNX) model, in ...