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Coauthors
Jean Gagnon Labroatoire Adaptation et Pathogénie des Microorganismes (LAPM), France
2 protocols

Marie-France Cesbron-Delauw Université Grenoble Alpes, France
2 protocols

Nicolas Blanchard Centre de Physiopathologie de Toulouse-Purpan (CPTP), France
1 protocol

Gregory Effantin Université Grenoble Alpes, France
1 protocol

Corinne Mercier
  • Université Grenoble Alpes, France
  • 1 Author merit

Education

PhD in Biology. University of Lille I, France, 1994

Current position

Assistant Professor = Instructor-Researcher (“Maître de Conférences”), Department of Chemistry-Biology, Université Grenoble Alpes, .France. Research at TIMC-IMAG, the CNRS UMR 5525 – Université Grenoble Alpes.

Publications (since 2006)

  1. Rommereim, L. M., Bellini, V., Fox, B. A., Petre, G., Rak, C., Touquet, B., Aldebert, D., Dubremetz, J. F., Cesbron-Delauw, M. F., Mercier, C. and Bzik, D. J. (2016). Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii. PLoS One 11(7): e0159306.

  2. Mercier, C. and Cesbron-Delauw, M. F. (2015). Toxoplasma secretory granules: one population or more? Trends Parasitol 31(2): 60-71.

  3. Lopez, J., Bittame, A., Massera, C., Vasseur, V., Effantin, G., Valat, A., Buaillon, C., Allart, S., Fox, B. A., Rommereim, L. M., Bzik, D. J., Schoehn, G., Weissenhorn, W., Dubremetz, J. F., Gagnon, J., Mercier, C., Cesbron-Delauw, M. F. and Blanchard, N. (2015). Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen. Cell Rep 13(10): 2273-2286.

  4. Bittame, A., Effantin, G., Petre, G., Ruffiot, P., Travier, L., Schoehn, G., Weissenhorn, W., Cesbron-Delauw, M. F., Gagnon, J. and Mercier, C. (2015). Toxoplasma gondii: biochemical and biophysical characterization of recombinant soluble dense granule proteins GRA2 and GRA6. Biochem Biophys Res Commun 459(1): 107-112.

  5. Saidani, N., Botte, C. Y., Deligny, M., Bonneau, A. L., Reader, J., Lasselin, R., Merer, G., Niepceron, A., Brossier, F., Cintrat, J. C., Rousseau, B., Birkholtz, L. M., Cesbron-Delauw, M. F., Dubremetz, J. F., Mercier, C., Vial, H., Lopez, R. and Marechal, E. (2014). Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs. Antimicrob Agents Chemother 58(5): 2586-2597.

  6. Azzouz, N., Kamena, F., Laurino, P., Kikkeri, R., Mercier, C., Cesbron-Delauw, M. F., Dubremetz, J. F., De Cola, L. and Seeberger, P. H. (2013). Toxoplasma gondii secretory proteins bind to sulfated heparin structures. Glycobiology 23(1): 106-120.

  7. Persat, F., Mercier, C., Ficheux, D., Colomb, E., Trouillet, S., Bendridi, N., Musset, K., Loeuillet, C., Cesbron-Delauw, M. F. and Vincent, C. (2012). A synthetic peptide derived from the parasite Toxoplasma gondii triggers human dendritic cells' migration. J Leukoc Biol 92(6): 1241-1250.

  8. Hester, J., Mullins, J., Sa, Q., Payne, L., Mercier, C., Cesbron-Delauw, M. F. and Suzuki, Y. (2012). Toxoplasma gondii antigens recognized by IgG antibodies differ between mice with and without active proliferation of tachyzoites in the brain during the chronic stage of infection. Infect Immun 80(10): 3611-3620.

  9. Mercier, C. and Delauw M. F. (2012). Safe living within a parasitophorous vacuole: the recipe of success by Toxoplasma gondii. In: Ghigo, E., Mottola, G. and Mege, J-L. (eds). Host-Pathogen interaction: At the frontier of cellular microbiology. Transworld Res. Network, Kerala, India. pp 217-250.

  10. Muniz-Hernandez, S., Carmen, M. G., Mondragon, M., Mercier, C., Cesbron, M. F., Mondragon-Gonzalez, S. L., Gonzalez, S. and Mondragon, R. (2011). Contribution of the residual body in the spatial organization of Toxoplasma gondii tachyzoites within the parasitophorous vacuole. J Biomed Biotechnol 2011: 473983.

  11. Fox, B. A., Falla, A., Rommereim, L. M., Tomita, T., Gigley, J. P., Mercier, C., Cesbron-Delauw, M. F., Weiss, L. M. and Bzik, D. J. (2011). Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection. Eukaryot Cell 10(9): 1193-1206.

  12. Koethe, M., Pott, S., Ludewig, M., Bangoura, B., Zoller, B., Daugschies, A., Tenter, A. M., Spekker, K., Bittame, A., Mercier, C., Fehlhaber, K. and Straubinger, R. K. (2011). Prevalence of specific IgG-antibodies against Toxoplasma gondii in domestic turkeys determined by kinetic ELISA based on recombinant GRA7 and GRA8. Vet Parasitol 180(3-4): 179-190.

  13. Gendrin, C., Bittame, A., Mercier, C. and Cesbron-Delauw, M. F. (2010). Post-translational membrane sorting of the Toxoplasma gondii GRA6 protein into the parasite-containing vacuole is driven by its N-terminal domain. Int J Parasitol 40(11): 1325-1334.

  14. Mercier, C., Travier, L., Bittame, A., Gendrin, C. and Cesbron-Delauw, M. F. (2010). The dense granule proteins of Toxoplasma gondii. In: De Bruyn, O. and Peeters, S. (eds). Parasitology Research Trends. Nova Science Publishers, pp 1-31.

  15. Michelin, A., Bittame, A., Bordat, Y., Travier, L., Mercier, C., Dubremetz, J. F. and Lebrun, M. (2009). GRA12, a Toxoplasma dense granule protein associated with the intravacuolar membranous nanotubular network. Int J Parasitol 39(3): 299-306.

  16. Cesbron-Delauw, M. F., Gendrin, C., Travier, L., Ruffiot, P. and Mercier, C. (2008). Apicomplexa in mammalian cells: trafficking to the parasitophorous vacuole. Traffic 9(5): 657-664.

  17. Gendrin, C., Mercier, C., Braun, L., Musset, K., Dubremetz, J. F. and Cesbron-Delauw, M. F. (2008). Toxoplasma gondii uses unusual sorting mechanisms to deliver transmembrane proteins into the host-cell vacuole. Traffic 9(10): 1665-1680.

  18. Morisset, S., Peyron, F., Lobry, J. R., Garweg, J., Ferrandiz, J., Musset, K., Gomez-Marin, J. E., de la Torre, A., Demar, M., Carme, B., Mercier, C., Garin, J. F. and Cesbron-Delauw, M. F. (2008). Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America. Microbes Infect 10(7): 742-747.

  19. Golkar, M., Azadmanesh, K., Khalili, G., Khoshkholgh-Sima, B., Babaie, J., Mercier, C., Brenier-Pinchart, M. P., Fricker-Hidalgo, H., Pelloux, H. and Cesbron-Delauw, M. F. (2008). Serodiagnosis of recently acquired Toxoplasma gondii infection in pregnant women using enzyme-linked immunosorbent assays with a recombinant dense granule GRA6 protein. Diagn Microbiol Infect Dis 61(1): 31-39.

  20. Botte, C., Saidani, N., Mondragon, R., Mondragon, M., Isaac, G., Mui, E., McLeod, R., Dubremetz, J. F., Vial, H., Welti, R., Cesbron-Delauw, M. F., Mercier, C. and Marechal, E. (2008). Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii. J Lipid Res 49(4): 746-762.

  21. Travier, L., Mondragon, R., Dubremetz, J. F., Musset, K., Mondragon, M., Gonzalez, S., Cesbron-Delauw, M. F. and Mercier, C. (2008). Functional domains of the Toxoplasma GRA2 protein in the formation of the membranous nanotubular network of the parasitophorous vacuole. Int J Parasitol 38(7): 757-773.

  22. Braun, L., Travier, L., Kieffer, S., Musset, K., Garin, J., Mercier, C. and Cesbron-Delauw, M. F. (2008). Purification of Toxoplasma dense granule proteins reveals that they are in complexes throughout the secretory pathway. Mol Biochem Parasitol 157(1): 13-21.

  23. Aldebert, D., Durand, F., Mercier, C., Brenier-Pinchart, M. P., Cesbron-Delauw, M. F. and Pelloux, H. (2007). Toxoplasma gondii triggers secretion of interleukin-12 but low level of interleukin-10 from the THP-1 human monocytic cell line. Cytokine 37(3): 206-211.

  24. Golkar, M., Rafati, S., Abdel-Latif, M. S., Brenier-Pinchart, M. P., Fricker-Hidalgo, H., Sima, B. K., Babaie, J., Pelloux, H., Cesbron-Delauw, M. F. and Mercier, C. (2007). The dense granule protein GRA2, a new marker for the serodiagnosis of acute Toxoplasma infection: comparison of sera collected in both France and Iran from pregnant women. Diagn Microbiol Infect Dis 58(4): 419-426.

  25. Golkar, M., Shokrgozar, M. A., Rafati, S., Musset, K., Assmar, M., Sadaie, R., Cesbron-Delauw, M. F. and Mercier, C. (2007). Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma chronic infection in mice. Vaccine 25(21): 4301-4311.

  26. Mercier, C., Cesbron-Delauw, M. F. and Ferguson, D. J. P. (2007). Dense granules of the infectious stages of Toxoplasma gondii: Their central role in the host/parasite relationship. In: Soldati, D. and Ajioka, J. (eds). Toxoplasma: Molecular and Cellular Biology, Horizon Bioscience, Norfolk, UK. pp 475-492.

  27. Azzouz, N., Shams-Eldin, H., Niehus, S., Debierre-Grockiego, F., Bieker, U., Schmidt, J., Mercier, C., Cesbron-Delauw, M. F., Dubremetz, J. F., Smith, T. K. and Schwarz, R. T. (2006). Toxoplasma grown in human cells use GalNAc- containing glycosylphosphatidylinositol precursors to anchor plasma surface antigens while the immunogenic Glc-GalNAc- containing precursors remain free at the parasite cell surface. Int. J. Biochem. Cell Biol. 38:1914-1925.

  28. Peyron, F., Lobry, J. R., Musset, K., Ferrandiz, J., Gomez-Marin, J. E., Petersen, E., Meroni, V., Rausher, B., Mercier, C., Picot, S. and Cesbron-Delauw, M. F. (2006). Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America). Microbes Infect 8(9-10): 2333-2340.

  29. Brenier-Pinchart, M. P., Villena, I., Mercier, C., Durand, F., Simon, J., Cesbron-Delauw, M. F. and Pelloux, H. (2006). The Toxoplasma surface protein SAG1 triggers efficient in vitro secretion of chemokine ligand 2 (CCL2) from human fibroblasts. Microbes Infect 8(1): 254-261.

1 Protocol published
Lipid Extraction from HeLa Cells, Quantification of Lipids, Formation of Large Unilamellar Vesicles (LUVs) by Extrusion and in vitro Protein-lipid Binding Assays, Analysis of the Incubation Product by Transmission Electron Microscopy (TEM) and by Flotation across a Discontinuous Sucrose Gradient
Dissecting the interactions established between proteins and membranes in a given type of cells is not an easy task. Using a cell-free system of large unilamellar vesicles (LUVs) to analyze these interactions may help decipher these interactions and ...