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Coauthors
Hexin Chen Department of Biological Science, University of South Carolina, USA
3 protocols

Shou Liu
  • Department of Biological Science, University of South Carolina, USA
Research focus
  • Cancer biology
Contributions
  • 1 Author merit

Education

Ph. D., Biochemistry, Purdue University, West Lafayette, IN, August 2014

Current position

Postdoctoral Research in Tumor biology, University of South Carolina, Columbia

Publications

  1. Patel, Y., Shah, N., Lee, J. S., Markoutsa, E., Jie, C., Liu, S., Botbyl, R., Reisman, D., Xu, P. and Chen, H. (2016). A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth. Oncotarget 7(14): 18295-18308.

  2. Liu, S., Jin, K., Hui, Y., Fu, J., Jie, C., Feng, S., Reisman, D., Wang, Q., Fan, D., Sukumar, S. and Chen, H. (2015). HOXB7 promotes malignant progression by activating the TGFbeta signaling pathway. Cancer Res 75(4): 709-719.

  3. Feng, S., Duan, X., Lo, P. K., Liu, S., Liu, X., Chen, H. and Wang, Q. (2013). Expansion of breast cancer stem cells with fibrous scaffolds. Integr Biol (Camb) 5(5): 768-777.

  4. Liu, X., Johnson, S., Liu, S., Kanojia, D., Yue, W., Singh, U. P., Wang, Q., Wang, Q., Nie, Q. and Chen, H. (2013). Nonlinear growth kinetics of breast cancer stem cells: implications for cancer stem cell targeted therapy. Sci Rep 3: 2473.

  5. Yan, W., Liu, S., Xu, E., Zhang, J., Zhang, Y., Chen, X. and Chen, X. (2013). Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. Oncogene 32(5): 599-609.

  6. Chen, X., Zhang, J., Zhang, M., Liu, S., Yan, W., Jung, J. and Chen, X. (2012). Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation. J Biol Chem 287(41): 34410-34418.

  7. Yan, W., Zhang, Y., Zhang, J., Liu, S., Cho, S. J. and Chen, X. (2011). Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. J Biol Chem 286(20): 17478-17486.

  8. Liu, S., Tan, W. Y., Chen, Q. R., Chen, X. P., Fu, K., Zhao, Y. Y. and Chen, Z. W. (2008). Daintain/AIF-1 promotes breast cancer proliferation via activation of the NF-kappaB/cyclin D1 pathway and facilitates tumor growth. Cancer Sci 99(5): 952-957.

  9. Chen, X. P., Liu, S., Tang, W. X. and Chen, Z. W. (2007). Nuclear thioredoxin-1 is required to suppress cisplatin-mediated apoptosis of MCF-7 cells. Biochem Biophys Res Commun 361(2): 362-366.

1 Protocol published
Isolation of Primary Breast Cancer Cells from HER2 Transgenic Mice
Authors:  Shou Liu and Hexin Chen, date: 10/05/2016, view: 1596, Q&A: 0
HER2 is a tyrosine kinase receptor, which is overexpressed in about 30% of breast cancer patients. Its overexpression leads to mammary tumorigenesis and increased invasion and metastasis (Slamon et al., 1987). HER2 transgenic mouse ...