Alfred Robison Department of Physiology and Neuroscience Program, Michigan State University, USA
2 protocols

Andrew Eagle Michigan State University
2 protocols

Hongbing Wang
  • Department of Physiology and Neuroscience Program, Michigan State University, USA
  • 1 Author merit


Ph.D. in Molecular and Medical Pharmacology, University of California, Los Angeles, USA

Current position

Associate professor of Physiology and Nueroscience, Michigan State University, East Lansing, USA

Publications (since 2005)

  1. Ding, Q., Sethna, F. and Wang, H. (2014). Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background. Behav Brain Res 271: 72-78. (Epub ahead of print)
  2. Son, Y., Yang, M., Kim, J. S., Kim, J., Kim, S. H., Kim, J. C., Shin, T., Wang, H., Jo, S. K., Jung, U. and Moon, C. (2014). Hippocampal dysfunction during the chronic phase following a single exposure to cranial irradiation. Exp Neurol 254: 134-144.
  3. Sethna, F., Moon, C. and Wang, H. (2014). From FMRP function to potential therapies for fragile X syndrome. Neurochem Res 39(6): 1016-1031.
  4. Yang, M., Kim, J., Kim, J. S., Kim, S. H., Kim, J. C., Kang, M. J., Jung, U., Shin, T., Wang, H. and Moon, C. (2014). Hippocampal dysfunctions in tumor-bearing mice. Brain Behav Immun 36: 147-155.
  5. Zhou, X., Ding, Q., Chen, Z., Yun, H. and Wang, H. (2013). Involvement of the GluN2A and GluN2B subunits in synaptic and extrasynaptic N-methyl-D-aspartate receptor function and neuronal excitotoxicity. J Biol Chem 288(33): 24151-24159.
  6. Kim, J., Yang, M., Kim, S. H., Kim, J. C., Wang, H., Shin, T. and Moon, C. (2013). Possible role of the glycogen synthase kinase-3 signaling pathway in trimethyltin-induced hippocampal neurodegeneration in mice. PLoS One 8(8): e70356.
  7. Zhang, M. and Wang, H. (2013). Mice overexpressing type 1 adenylyl cyclase show enhanced spatial memory flexibility in the absence of intact synaptic long-term depression. Learn Mem 20(7): 352-357.
  8. Packiriswamy, N., Lee, T., Raghavendra, P. B., Durairaj, H., Wang, H. and Parameswaran, N. (2013). G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice. J Innate Immun 5(4): 401-413.
  9. Zhou, X., Hollern, D., Liao, J., Andrechek, E. and Wang, H. (2013). NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors. Cell Death Dis 4: e560.
  10. Yang, M., Kim, J. S., Kim, J., Jang, S., Kim, S. H., Kim, J. C., Shin, T., Wang, H. and Moon, C. (2012). Acute treatment with methotrexate induces hippocampal dysfunction in a mouse model of breast cancer. Brain Res Bull 89(1-2): 50-56.
  11. Zheng, F., Zhou, X., Moon, C. and Wang, H. (2012). Regulation of brain-derived neurotrophic factor expression in neurons. Int J Physiol Pathophysiol Pharmacol 4(4): 188-200.
  12. Wang, H. and Zhang, M. (2012). The role of Ca(2)(+)-stimulated adenylyl cyclases in bidirectional synaptic plasticity and brain function. Rev Neurosci 23(1): 67-78.
  13. Zhou, X., Zheng, F., Moon, C., Schluter, O. M. and Wang, H. (2012). Bi-directional regulation of CaMKIIalpha phosphorylation at Thr286 by NMDA receptors in cultured cortical neurons. J Neurochem 122(2): 295-307.
  14. Zhou, X., Xiao, H. and Wang, H. (2011). Developmental changes of TrkB signaling in response to exogenous brain-derived neurotrophic factor in primary cortical neurons. J Neurochem 119(6): 1205-1216.
  15. Zheng, F., Zhou, X., Luo, Y., Xiao, H., Wayman, G. and Wang, H. (2011). Regulation of brain-derived neurotrophic factor exon IV transcription through calcium responsive elements in cortical neurons. PLoS One 6(12): e28441.
  16. Zhang, M., Storm, D. R. and Wang, H. (2011). Bidirectional synaptic plasticity and spatial memory flexibility require Ca2+-stimulated adenylyl cyclases. J Neurosci 31(28): 10174-10183.
  17. Kujjo, L. L., Chang, E. A., Pereira, R. J., Dhar, S., Marrero-Rosado, B., Sengupta, S., Wang, H., Cibelli, J. B. and Perez, G. I. (2011). Chemotherapy-induced late transgenerational effects in mice. PLoS One 6(3): e17877.
  18. Yang, M., Kim, J. S., Kim, J., Kim, S. H., Kim, J. C., Kim, J., Wang, H., Shin, T. and Moon, C. (2011). Neurotoxicity of methotrexate to hippocampal cells in vivo and in vitro. Biochem Pharmacol 82(1): 72-80.
  19. Seo, H. S., Yang, M., Song, M. S., Kim, J. S., Kim, S. H., Kim, J. C., Kim, H., Shin, T., Wang, H. and Moon, C. (2010). Toluene inhibits hippocampal neurogenesis in adult mice. Pharmacol Biochem Behav 94(4): 588-594.
  20. Yang, M., Kim, J. S., Song, M. S., Kim, S. H., Kang, S. S., Bae, C. S., Kim, J. C., Wang, H., Shin, T. and Moon, C. (2010). Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: Possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits. Neurobiol Learn Mem 93(4): 487-494.
  21. Ottem, E. N., Poort, J. E., Wang, H., Jordan, C. L. and Breedlove, S. M. (2010). Differential expression and regulation of brain-derived neurotrophic factor (BDNF) mRNA isoforms in androgen-sensitive motoneurons of the rat lumbar spinal cord. Mol Cell Endocrinol 328(1-2): 40-46.
  22. Zhou, X., Lin, D. S., Zheng, F., Sutton, M. A. and Wang, H. (2010). Intracellular calcium and calmodulin link brain-derived neurotrophic factor to p70S6 kinase phosphorylation and dendritic protein synthesis. J Neurosci Res 88(7): 1420-1432.
  23. Wang, Y.*, Zhang, M.*, Moon, C., Hu, Q., Wang, B., Martin, G., Sun, Z. and Wang, H. (2009). The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation. Learn Mem 16(9): 537-544.   
  24. Wang, Y., Zheng, F., Zhou, X., Sun, Z. and Wang, H. (2009). Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription. Neurosci Lett 460(1): 36-40.
  25. Zhou, X., Moon, C., Zheng, F., Luo, Y., Soellner, D., Nunez, J. L. and Wang, H. (2009). N-methyl-D-aspartate-stimulated ERK1/2 signaling and the transcriptional up-regulation of plasticity-related genes are developmentally regulated following in vitro neuronal maturation. J Neurosci Res 87(12): 2632-2644.
  26. Song, M. S., Seo, H. S., Yang, M., Kim, J. S., Kim, S. H., Kim, J. C., Wang, H., Sim, K. B., Kim, H., Shin, T. and Moon, C. (2009). Activation of Ca2+/calmodulin-dependent protein kinase II alpha in the spinal cords of rats with clip compression injury. Brain Res 1271: 114-120.
  27. Zheng, F. and Wang, H. (2009). NMDA-mediated and self-induced bdnf exon IV transcriptions are differentially regulated in cultured cortical neurons. Neurochem Int 54(5-6): 385-392.
  28. Kim, J. S., Jung, J., Lee, H. J., Kim, J. C., Wang, H., Kim, S. H., Shin, T. and Moon, C. (2009). Differences in immunoreactivities of Ki-67 and doublecortin in the adult hippocampus in three strains of mice. Acta Histochem 111(2): 150-156.
  29. Kim, J. S., Lee, H. J., Kim, J. C., Kang, S. S., Bae, C. S., Shin, T., Jin, J. K., Kim, S. H., Wang, H. and Moon, C. (2008). Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. J Radiat Res 49(5): 517-526.
  30. Eckel-Mahan, K. L., Phan, T., Han, S., Wang, H., Chan, G. C., Scheiner, Z. S. and Storm, D. R. (2008). Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence. Nat Neurosci 11(9): 1074-1082.
  31. Zheng, F., Luo, Y. and Wang, H. (2009). Regulation of brain-derived neurotrophic factor-mediated transcription of the immediate early gene Arc by intracellular calcium and calmodulin. J Neurosci Res 87(2): 380-392.
  32. Zheng, F., Soellner, D., Nunez, J. and Wang, H. (2008). The basal level of intracellular calcium gates the activation of phosphoinositide 3-kinase-Akt signaling by brain-derived neurotrophic factor in cortical neurons. J Neurochem 106(3): 1259-1274.
  33. Zhang, M.*, Moon, C.*, Chan, G. C., Yang, L., Zheng, F., Conti, A. C., Muglia, L., Muglia, L. J., Storm, D. R. and Wang, H. (2008). Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory. J Neurosci 28(18): 4736-4744. (*Co-first author)
  34. Moon, C., Kim, H., Ahn, M., Jin, J. K., Wang, H., Matsumoto, Y. and Shin, T. (2006). Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder. J Neuroimmunol 172(1-2): 66-72.
  35. Chen, X., Garelick, M. G., Wang, H., Lil, V., Athos, J. and Storm, D. R. (2005). PI3 kinase signaling is required for retrieval and extinction of contextual memory. Nat Neurosci 8(7): 925-931.
  36. Wang, H, and Storm, D. (2005). Ca2+-stimulated Adenylyl Cyclases and Hippocampal Neuroplasticity. Cellscience. 2, 73-91.
1 Protocol published
Sensitive Assessment of Hippocampal Learning Using Temporally Dissociated Passive Avoidance Task
Authors:  Andrew L. Eagle, Hongbing Wang and Alfred J. Robison, date: 06/05/2016, view: 2186, Q&A: 0
The temporally dissociated passive avoidance (TDPA) paradigm is a variant of passive avoidance testing, and allows for more sensitive investigation of mild impairments in avoidance learning. Passive avoidance learning measures the latency to enter a ...