Search
Coauthors
Javier Di Noia Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Astrid Zahn Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Anne-Marie Patenaude Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Stephen Methot Institut de Recherches Cliniques de Montréal, Canada
1 protocol

Ludivine C. Litzler
  • Institut de Recherches Cliniques de Montréal, Canada
Contributions
  • 1 Author merit

Education

M.S. in Biothechnology, Ecole Supérieure de Biotechnologie de Strasbourg, Université de Strasbourg, 2011

Current position

Doctoral student, Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, Canada

Publications

  1. Montamat-Sicotte, D., Litzler, L. C., Abreu, C., Safavi, S., Zahn, A., Orthwein, A., Muschen, M., Oppezzo, P., Munoz, D. P. and Di Noia, J. M. (2015). HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol 45(8): 2365-2376.
  2. Methot, S. P., Litzler, L. C., Trajtenberg, F., Zahn, A., Robert, F., Pelletier, J., Buschiazzo, A., Magor, B. G. and Di Noia, J. M. (2015). Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J Exp Med 212(4): 581-596.
1 Protocol published
Cell-based Assays to Monitor AID Activity
The enzyme Activation induced deaminase (AID) underpins antibody affinity maturation and isotype switching through its mutagenic activity of deaminating deoxycytidine to deoxyuridine in DNA. Subsequent processing of the deoxyuridine initiates the ...