Xiaoyu Liu Division of Biosciences, The Ohio State University, USA
1 protocol

Ning Quan
  • Division of Biosciences, The Ohio State University, USA
  • 1 Author merit


Ph.D. in Physiology, University of Tennessee, Memphis, TN, 1991

Current position

Tenure Professor, Oral Biology and Institute of Behavior Medicine, Ohio State University (2009-present)
Chair, Oral Biology Graduate Program, Ohio State University (2009-present)


  1. Chen, Q., Tarr, A. J., Liu, X., Wang, Y., Reed, N. S., Demarsh, C. P., Sheridan, J. F. and Quan, N. (2013). Controlled progressive innate immune stimulation regimen prevents the induction of sickness behavior in the open field test. J Inflamm Res 6: 91-98.
  2. Qian, J., Zhu, L., Li, Q., Belevych, N., Chen, Q., Zhao, F., Herness, S. and Quan, N. (2012). Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proc Natl Acad Sci U S A 109(30): 12189-12194.
  3. Tarr, A. J., Chen, Q., Wang, Y., Sheridan, J. F. and Quan, N. (2012). Neural and behavioral responses to low-grade inflammation. Behav Brain Res 235(2): 334-341.
  4. An, Y., Chen, Q. and Quan, N. (2011). Interleukin-1 exerts distinct actions on different cell types of the brain in vitro. J Inflamm Res 2011(4): 11-20.
  5. Li, Q., Powell, N., Zhang, H., Belevych, N., Ching, S., Chen, Q., Sheridan, J., Whitacre, C. and Quan, N. (2011). Endothelial IL-1R1 is a critical mediator of EAE pathogenesis. Brain Behav Immun 25(1): 160-167.
  6. Belevych, N., Buchanan, K., Chen, Q., Bailey, M. and Quan, N. (2010). Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation. Brain Behav Immun 24(7): 1137-1147.
  7. Li, Q., Zhang, H., Chen, Q. and Quan, N. (2010). Existence of seven human IL-1R1 promoters. J Inflamm Res 2010(3): 17-24.
  8. Reiser, P. J., Bicer, S., Chen, Q., Zhu, L. and Quan, N. (2009). Masticatory (;superfast') myosin heavy chain and embryonic/atrial myosin light chain 1 in rodent jaw-closing muscles. J Exp Biol 212(Pt 16): 2511-2519.
  9. Chen, Q., Zhang, H., Li, Q., An, Y., Herkenham, M., Lai, W., Popovich, P., Agarwal, S. and Quan, N. (2009). Three Promoters Regulate Tissue- and Cell Type-specific Expression of Murine Interleukin-1 Receptor Type I. J Biol Chem 284(13): 8703-8713.
  10. Bicer, S., Reiser, P. J., Ching, S. and Quan, N. (2009). Induction of muscle weakness by local inflammation: an experimental animal model. Inflamm Res 58(4): 175-183.
  11. Zhang, H., Ching, S., Chen, Q., Li, Q., An, Y. and Quan, N. (2008). Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain. Neuroscience 157(4): 895-907.
  12. Engler, H., Bailey, M. T., Engler, A., Stiner-Jones, L. M., Quan, N. and Sheridan, J. F. (2008). Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen. Psychoneuroendocrinology 33(1): 108-117.
  13. Ching, S., Zhang, H., Belevych, N., He, L., Lai, W., Pu, X. A., Jaeger, L. B., Chen, Q. and Quan, N. (2007). Endothelial-specific knockdown of interleukin-1 (IL-1) type 1 receptor differentially alters CNS responses to IL-1 depending on its route of administration. J Neurosci 27(39): 10476-10486.
  14. Ching, S., Zhang, H., Chen, Q. and Quan, N. (2007). Differential expression of extracellular matrix and adhesion molecule genes in the brain of juvenile versus adult mice in responses to intracerebroventricular administration of IL-1. Neuroimmunomodulation 14(1): 46-56.
  15. Dossumbekova, A., Anghelina, M., Madhavan, S., He, L., Quan, N., Knobloch, T. and Agarwal, S. (2007). Inhibition of IKK activity mediates attenuation of proinflammatory gene induction by Biomechanical signals in chondrocytes. Arthritis and Rheumatism 56: 3284-96.
  16. Ching, S., Zhang, H., Lai, W. and Quan, N. (2006). Peripheral injection of lipopolysaccharide prevents brain recruitment of leukocytes induced by central injection of interleukin-1. Neuroscience 137(2): 717-726.
  17. Chen, R., Tilley, M. R., Wei, H., Zhou, F., Zhou, F. M., Ching, S., Quan, N., Stephens, R. L., Hill, E. R., Nottoli, T., Han, D. D. and Gu, H. H. (2006). Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci U S A 103(24): 9333-9338.
  18. Dunn, A. J., Swiergiel, A. H., Zhang, H. and Quan, N. (2006). Reduced ingestion of sweetened milk induced by interleukin-1 and lipopolysaccharide is associated with induction of cyclooxygenase-2 in brain endothelia. Neuroimmunomodulation 13(2): 96-104.
  19. Quan, N. (2006). Brain's firewall: blood-brain barrier actively regulates neuroimmune information flow. Brain Behav Immun 20(5): 447-448.
  20. Ching, S., He, L., Lai, W. and Quan, N. (2005). IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav Immun 19(2): 127-137.
  21. Horan, M. P., Quan, N., Subramanian, S. V., Strauch, A. R., Gajendrareddy, P. K. and Marucha, P. T. (2005). Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice. Brain Behav Immun 19(3): 207-216.
  22. Pyter, L. M., Samuelsson, A. R., Quan, N. and Nelson, R. J. (2005). Photoperiod alters hypothalamic cytokine gene expression and sickness responses following immune challenge in female Siberian hamsters (Phodopus sungorus). Neuroscience 131(4): 779-784.
  23. Ledeboer, A., Gamanos, M., Lai, W., Maier, S. F., Watkins, L. R. and Quan, N. (2005). Role of spinal cord nuclear factor B (NF-B) activation in rat models of pain facilitation. Eur J Neurosci 22 8: 1977-1986.
1 Protocol published
Immune Cell Isolation from Mouse Femur Bone Marrow
Authors:  Xiaoyu Liu and Ning Quan, date: 10/20/2015, view: 5033, Q&A: 0
The bone marrow is the site of hematopoiesis and contains mixed population of blood cells including erythrocytes, granulocytes, monocytes, dendritic cells, lymphocytes and hematopoietic stem cells. The following protocol provides a simple and fast ...