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Coauthors
Ming Li Immunology Program, Memorial Sloan Kettering Cancer Center, USA
3 protocols
Coreviewers
Benoit Chassaing Georgia State University
11 protocols

Filipa Vaz University of Glasgow
6 protocols

Jalaj Gupta Georg Speyer Haus
7 protocols

Lee-Hwa Tai Universite de Sherbrooke
20 protocols

Editor
Ruth A. Franklin
  • Yale University
Research focus
  • Immunology
  • 1 Author merit

Education

Ph.D. in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, 2014

Current position

Postdoctoral Research Fellow, Department of Immunobiology, Yale School of Medicine, New Haven, CT

Publications

  1. Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. S. and Li, M. O. (2016). Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells. Cell 164(3): 365-377.
  2. Franklin, R. A. and Li, M. O. (2016). Ontogeny of tumor-associated macrophages and its implication in cancer regulation. Trends Cancer 2(1): 20-34.      
  3. Franklin, R. A. and Li, M. O. (2014). The ontogeny of tumor-associated macrophages: a new understanding of cancer-elicited inflammation. Oncoimmunology 3(9): e955346.
  4. Franklin, R. A., Liao, W., Sarkar, A., Kim, M. V., Bivona, M. R., Liu, K., Pamer, E. G. and Li, M. O. (2014). The cellular and molecular origin of tumor-associated macrophages. Science 344(6186): 921-925.
  5. Donkor, M. K., Sarkar, A., Savage, P. A., Franklin, R. A., Johnson, L. K., Jungbluth, A. A., Allison, J. P. and Li, M. O. (2011). T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-beta1 cytokine. Immunity 35(1): 123-134.
  6. Dorrell, M. I., Aguilar, E., Jacobson, R., Trauger, S. A., Friedlander, J., Siuzdak, G. and Friedlander, M. (2010). Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy. Glia 58(1): 43-54.
  7. Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., Siuzdak, G. and Friedlander, M. (2009). Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest 119(3): 611-623.
  8. Aguilar, E., Dorrell, M. I., Friedlander, D., Jacobson, R. A., Johnson, A., Marchetti, V., Moreno, S. K., Ritter, M. R. and Friedlander, M. (2008). Chapter 6. Ocular models of angiogenesis. Methods Enzymol 444: 115-158.
  9. Scheppke, L., Aguilar, E., Gariano, R. F., Jacobson, R., Hood, J., Doukas, J., Cao, J., Noronha, G., Yee, S., Weis, S., Martin, M. B., Soll, R., Cheresh, D. A. and Friedlander, M. (2008). Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits. J Clin Invest 118(6): 2337-2346.

1 Protocol published
Determining Leukocyte Origins Using Parabiosis in the PyMT Breast Tumor Model
Authors:  Ruth A. Franklin and Ming O. Li, date: 08/20/2015, view: 3197, Q&A: 0
Tumors develop in a complex microenvironment alongside numerous cell types that impact their survival. Immune cells make up a large proportion of these accessory cells and many are known to promote tumor progression. Macrophages, in particular, are ...
4 Protocols reviewed
In vivo Efficacy Studies in Cell Line and Patient-derived Xenograft Mouse Models
Authors:  Elizabeth A. Tovar, Curt J. Essenburg and Carrie Graveel, date: 01/05/2017, view: 2535, Q&A: 0
In vivo xenograft models derived from human cancer cells have been a gold standard for evaluating the genetic drivers of cancer and are valuable preclinical models for evaluating the efficacy of cancer therapeutics. Recently, ...
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Phagocytosis Assay to Measure Uptake of Necroptotic Cancer Cells by BMDCs
Authors:  Tania Løve Aaes, Dmitri V. Krysko and Peter Vandenabeele, date: 11/05/2016, view: 2424, Q&A: 0
This protocol is a flow cytometry-based method to measure the phagocytosis efficiency of necroptotic target cells by bone marrow-derived dendritic cells (BMDCs) in vitro (Aaes et al., 2016). The method is a slightly modified and ...
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5 Protocols edited
Isolation and Infection of Drosophila Primary Hemocytes
Authors:  Charles Tracy and Helmut Krämer, date: 06/05/2017, view: 1328, Q&A: 0
Phagocytosis of invading pathogens and their subsequent clearance in lysosomes is important for organismal fitness. We have devised the following protocol to extract phagocytic hemocytes from wild-type and mutant Drosophila larvae and ...
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Escherichia coli Infection of Drosophila
Authors:  Charles Tracy and Helmut Krämer, date: 05/05/2017, view: 1204, Q&A: 0
Following septic insults, healthy insects, just like vertebrates, mount a complex immune response to contain and destroy pathogens. The failure to efficiently clear bacterial infections in immuno-compromised fly mutants leads to higher mortality ...
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