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Coauthors
Luigi Terracciano Institute of Pathology, University Hospital Basel, Switzerland
1 protocol

Luigi Tornillo Institute of Pathology, University Hospital Basel, Switzerland
1 protocol

Sandra Schneider Institute of Pathology, University Hospital Basel, Switzerland
1 protocol

Leila Arabi Institute of Pathology, University Hospital Basel, Switzerland
1 protocol

Luca Quagliata
  • Institute of Pathology, University Hospital Basel, Switzerland
Research focus
  • Molecular biology
Contributions
  • 1 Author merit

Education

Ph.D. in Vascular Medicine Magna cum Laude, Faculties for Natural Sciences and for Mathematics, Ruperto-Carola University of Heidelberg, Germany, 2011

Current position

NGS Unit Responsible,Institute of Pathology, University Hospital Basel (since 04/2014)

Publications

  1. Hansen, M. T., Forst, B., Cremers, N., Quagliata, L., Ambartsumian, N., Grum-Schwensen, B., Klingelhofer, J., Abdul-Al, A., Herrmann, P., Osterland, M., Stein, U., Nielsen, G. H., Scherer, P. E., Lukanidin, E., Sleeman, J. P. and Grigorian, M. (2015). A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4. Oncogene 34(4): 424-435.
  2. Rothweiler, S., Dill, M. T., Terracciano, L., Makowska, Z., Quagliata, L., Hlushchuk, R., Djonov, V., Heim, M. H. and Semela, D. (2015). Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model. Lab Invest 95(3): 351-362.
  3. Zavattari, P., Perra, A., Menegon, S., Kowalik, M. A., Petrelli, A., Angioni, M. M., Follenzi, A., Quagliata, L., Ledda-Columbano, G. M., Terracciano, L., Giordano, S. and Columbano, A. (2015). Nrf2, but not beta-catenin, mutation represents an early event in rat hepatocarcinogenesis. Hepatology.
  4. Andreozzi, M., Quagliata, L., Gsponer, J. R., Ruiz, C., Vuaroqueaux, V., Eppenberger-Castori, S., Tornillo, L. and Terracciano, L. M. (2014). VEGFA gene locus analysis across 80 human tumour types reveals gene amplification in several neoplastic entities. Angiogenesis 17(3): 519-527.
  5. Crea, F., Watahiki, A., Quagliata, L., Xue, H., Pikor, L., Parolia, A., Wang, Y., Lin, D., Lam, W. L., Farrar, W. L., Isogai, T., Morant, R., Castori-Eppenberger, S., Chi, K. N., Wang, Y. and Helgason, C. D. (2014). Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget 5(3): 764-774. 
  6. Quagliata, L., Andreozzi, M., Kovac, M., Tornillo, L., Makowska, Z., Moretti, F., Heim, M. H., Heinimann, K., Piscuoglio, S. and Terracciano, L. M. (2014). SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules. Eur J Cancer 50(4): 731-738.
  7. Quagliata, L., Klusmeier, S., Cremers, N., Pytowski, B., Harvey, A., Pettis, R. J., Thiele, W. and Sleeman, J. P. (2014). Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model. Clin Exp Metastasis 31(3): 351-365. 
  8. Horwitz, E., Stein, I., Andreozzi, M., Nemeth, J., Shoham, A., Pappo, O., Schweitzer, N., Tornillo, L., Kanarek, N., Quagliata, L., Zreik, F., Porat, R. M., Finkelstein, R., Reuter, H., Koschny, R., Ganten, T., Mogler, C., Shibolet, O., Hess, J., Breuhahn, K., Grunewald, M., Schirmacher, P., Vogel, A., Terracciano, L., Angel, P., Ben-Neriah, Y. and Pikarsky, E. (2014). Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. Cancer Discov 4(6): 730-743.
  9. Arabi, L., Gsponer, J. R., Smida, J., Nathrath, M., Perrina, V., Jundt, G., Ruiz, C., Quagliata, L. and Baumhoer, D. (2014). Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences. Genes Cancer 5(1-2): 56-63.
  10. Lepore, M., Kalinichenko, A., Colone, A., Paleja, B., Singhal, A., Tschumi, A., Lee, B., Poidinger, M., Zolezzi, F., Quagliata, L., Sander, P., Newell, E., Bertoletti, A., Terracciano, L., De Libero, G. and Mori, L. (2014). Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRbeta repertoire. Nat Commun 5: 3866.
  11. Cornu, M., Oppliger, W., Albert, V., Robitaille, A. M., Trapani, F., Quagliata, L., Fuhrer, T., Sauer, U., Terracciano, L. and Hall, M. N. (2014). Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. Proc Natl Acad Sci U S A 111(32): 11592-11599.
  12. Quagliata, L. and Terracciano, L. M. (2014). Liver Diseases and Long Non-Coding RNAs: New Insight and Perspective. Front Med (Lausanne) 1: 35.
  13. Hefetz-Sela, S., Stein, I., Klieger, Y., Porat, R., Sade-Feldman, M., Zreik, F., Nagler, A., Pappo, O., Quagliata, L., Dazert, E., Eferl, R., Terracciano, L., Wagner, E. F., Ben-Neriah, Y., Baniyash, M. and Pikarsky, E. (2014). Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation. Proc Natl Acad Sci U S A 111(49): 17582-17587.
  14. Quagliata, L., Matter, M. S., Piscuoglio, S., Arabi, L., Ruiz, C., Procino, A., Kovac, M., Moretti, F., Makowska, Z., Boldanova, T., Andersen, J. B., Hammerle, M., Tornillo, L., Heim, M. H., Diederichs, S., Cillo, C. and Terracciano, L. M. (2014). Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology 59(3): 911-923.
  15. Quagliata, L., Schlageter, M., Quintavalle, C., Tornillo, L. and Terracciano, L. (2014). Identification of new players in hepatocarcinogenesis: Limits and opportunities of using tissue microarray (TMA). Microarray 3(2): 91-102.
  16. Thiele, W., Rothley, M., Teller, N., Jung, N., Bulat, B., Plaumann, D., Vanderheiden, S., Schmaus, A., Cremers, N., Goppert, B., Dimmler, A., Eschbach, V., Quagliata, L., Thaler, S., Marko, D., Brase, S. and Sleeman, J. P. (2013). Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats. Carcinogenesis 34(12): 2804-2813.
  17. Thiele, W., Krishnan, J., Rothley, M., Weih, D., Plaumann, D., Kuch, V., Quagliata, L., Weich, H. A. and Sleeman, J. P. (2012). VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis. Blood 120(9): 1899-1907.
  18. Bimonte, S., De Angelis, A., Quagliata, L., Giusti, F., Tammaro, R., Dallai, R., Ascenzi, M. G., Diez-Roux, G. and Franco, B. (2011). Ofd1 is required in limb bud patterning and endochondral bone development. Dev Biol 349(2): 179-191.
1 Protocol published
DNA in situ Hybridizations for VEGFA Gene Locus (6p12) in Human Tumor Tissue
Over the last decades numerous regulators of angiogenesis have been identified and characterized. Among the others the vascular endothelial growth factor (VEGFA) appears undoubtedly important in several pathophysiological processes. Moreover, VEGFA ...