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Coauthors
Matthew Strain University of California San Diego, USA
1 protocol

Douglas Richman University of California San Diego, USA
1 protocol

Steven Lada University of California San Diego, La Jolla
1 protocol

Sara Gianella University of California San Diego, USA
2 protocols

Marta Massanella
  • University of California San Diego, USA
Contributions
  • 2 Author merit

Education

Ph.D. in Biomedicine, Pompeu Fabra University, Barcelona, Spain, 2012

Current position

Post-doctoral fellow in Center for AIDS Research (CFAR), Department of Pathology, University of California, San Diego, USA

Publications

  1. Beliakova-Bethell, N.*, Massanella, M.*, White, C., Lada, S. M., Du, P., Vaida, F., Blanco, J., Spina, C. A. and Woelk, C. H. (2014). The effect of cell subset isolation method on gene expression in leukocytes. Cytometry A 85(1): 94-104. (*Both authors contributed equally to this work)
  2. Puertas, M. C.*, Massanella, M.*, Llibre, J. M.*, Ballestero, M., Buzon, M. J., Ouchi, D., Esteve, A., Boix, J., Manzardo, C., Miro, J. M., Gatell, J. M., Clotet, B., Blanco, J., Martinez-Picado, J. and MaraviBoost Collaborative, G. (2014). Intensification of a raltegravir-based regimen with maraviroc in early HIV-1 infection. AIDS 28(3): 325-334. (*Both authors contributed equally to this work)
  3. Chaillon, A., Gianella, S., Luna, M. M., Little, S., Richman, D. and Mehta, S. (2014). A case cluster demonstrating the relationship between HLA concordance and virologic and disease outcomes in human immunodeficiency virus infection. Virology 449: 104-108.
  4. Gianella, S.*, Massanella, M.*, Richman, D. D., Little, S. J., Spina, C. A., Vargas, M. V., Lada, S. M., Daar, E. S., Dube, M. P., Haubrich, R. H., Morris, S. R., Smith, D. M. and California Collaborative Treatment Group, T. (2014). Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment. J Virol 88(14): 7818-7827. (*Both authors contributed equally to this work)
  5. Massanella, M., Ouchi, D., Marfil, S., Llibre, J. M., Puertas, M. C., Buzon, M. J., Richman, D. D., Orna, E., Stevenson, M., Gatell, J. M., Domingo, P., Negredo, E., Martinez-Picado, J., Clotet, B. and Blanco, J. (2014). Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individuals. PLoS One 9(12): e114142.
  6. Massanella, M., Esteve, A., Buzon, M. J., Llibre, J. M., Puertas, M. C., Gatell, J. M., Domingo, P., Stevenson, M., Clotet, B., Martinez-Picado, J., Blanco, J. and IntegRal Collaborative, G. (2013). Dynamics of CD8 T-cell activation after discontinuation of HIV treatment intensification. J Acquir Immune Defic Syndr 63(2): 152-160.
  7. Carrillo, J., Restrepo, C., Rallon, N. I., Massanella, M., del Romero, J., Rodriguez, C., Soriano, V., Clotet, B., Benito, J. M. and Blanco, J. (2013). HIV exposed seronegative individuals show antibodies specifically recognizing native HIV envelope glycoprotein. AIDS 27(9): 1375-1385.
  8. Perez-Santiago, J., Gianella, S., Massanella, M., Spina, C. A., Karris, M. Y., Var, S. R., Patel, D., Jordan, P. S., Young, J. A., Little, S. J., Richman, D. D. and Smith, D. M. (2013). Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS 27(12): 1921-1931.
  9. Curriu, M.*, Carrillo, J.*, Massanella, M.*, Rigau, J., Alegre, J., Puig, J., Garcia-Quintana, A. M., Castro-Marrero, J., Negredo, E., Clotet, B., Cabrera, C. and Blanco, J. (2013). Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome. J Transl Med 11: 68. (*All the authors contributed equally to this work)
  10. Massanella, M., Curriu, M., Carrillo, J., Gomez, E., Puig, J., Navarro, J., Dalmau, J., Martinez-Picado, J., Crespo, M., Cabrera, C., Negredo, E., Clotet, B. and Blanco, J. (2013). Assessing main death pathways in T lymphocytes from HIV infected individuals. Cytometry A 83(7): 648-658.
  11. Negredo, E.*, Massanella, M.*, Puertas, M. C., Buzon, M. J., Puig, J., Perez-Alvarez, N., Perez-Santiago, J., Bonjoch, A., Molto, J., Jou, A., Echeverria, P., Llibre, J. M., Martinez-Picado, J., Clotet, B. and Blanco, J. (2013). Early but limited effects of raltegravir intensification on CD4 T cell reconstitution in HIV-infected patients with an immunodiscordant response to antiretroviral therapy. J Antimicrob Chemother 68(10): 2358-2362. (*Both authors contributed equally to this work)
  12. Massanella, M.*, Singhania, A.*, Beliakova-Bethell, N., Pier, R., Lada, S. M., White, C. H., Perez-Santiago, J., Blanco, J., Richman, D. D., Little, S. J. and Woelk, C. H. (2013). Differential gene expression in HIV-infected individuals following ART. Antiviral Res 100(2): 420-428. (*Both authors contributed equally to this work)
  13. Llibre, J. M.*, Buzon, M. J.*, Massanella, M.*, Esteve, A., Dahl, V., Puertas, M. C., Domingo, P., Gatell, J. M., Larrouse, M., Gutierrez, M., Palmer, S., Stevenson, M., Blanco, J., Martinez-Picado, J. and Clotet, B. (2012). Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study. Antivir Ther 17(2): 355-364. (*Both authors contributed equally to this work)
  14. Curriu, M., Fausther-Bovendo, H., Pernas, M., Massanella, M., Carrillo, J., Cabrera, C., Lopez-Galindez, C., Clotet, B., Debre, P., Vieillard, V. and Blanco, J. (2012). Viremic HIV infected individuals with high CD4 T cells and functional envelope proteins show anti-gp41 antibodies with unique specificity and function. PLoS One 7(2): e30330.
  15. Curriu, M., Carrillo, J., Massanella, M., Garcia, E., Cunyat, F., Pena, R., Wienberg, P., Carrato, C., Areal, J., Bofill, M., Clotet, B., Blanco, J. and Cabrera, C. (2012). Susceptibility of human lymphoid tissue cultured ex vivo to xenotropic murine leukemia virus-related virus (XMRV) infection. PLoS One 7(5): e37415.
  16. Massanella, M.*, Negredo, E.*, Puig, J., Puertas, M. C., Buzon, M. J., Perez-Alvarez, N., Carrillo, J., Clotet, B., Martinez-Picado, J. and Blanco, J. (2012). Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery. AIDS 26(18): 2285-2293. (*Both authors contributed equally to this work)
  17. Casanova, V.*, Naval-Macabuhay, I.*, Massanella, M., Rodriguez-Garcia, M., Blanco, J., Gatell, J. M., Garcia, F., Gallart, T., Lluis, C., Mallol, J., Franco, R.*, Climent, N.* and McCormick, P. J.* (2012). Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals. PLoS One 7(12): e51287.
  18. Rotger, M.*, Dalmau, J.*, Rauch, A.*, McLaren, P.*, Bosinger, S. E.*, Martinez, R., Sandler, N. G., Roque, A., Liebner, J., Battegay, M., Bernasconi, E., Descombes, P., Erkizia, I., Fellay, J., Hirschel, B., Miro, J. M., Palou, E., Hoffmann, M., Massanella, M., Blanco, J., Woods, M., Gunthard, H. F., de Bakker, P., Douek, D. C., Silvestri, G., Martinez-Picado, J. and Telenti, A. (2011). Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Invest 121(6): 2391-2400.(*All the authors contributed equally to this work)
  19. Plana, M., Garcia, F., Darwich, L., Romeu, J., Lopez, A., Cabrera, C., Massanella, M., Canto, E., Ruiz-Hernandez, R., Blanco, J., Sanchez, M., Gatell, J. M., Clotet, B., Ruiz, L., Bofill, M. and Red de Investigacion en, S. (2011). The reconstitution of the thymus in immunosuppressed individuals restores CD4-specific cellular and humoral immune responses. Immunology 133(3): 318-328.
  20. Sanchez-Palomino, S.*, Massanella, M.*, Carrillo, J., Garcia, A., Garcia, F., Gonzalez, N., Merino, A., Alcami, J., Bofill, M., Yuste, E., Gatell, J. M., Clotet, B. and Blanco, J. (2011). A cell-to-cell HIV transfer assay identifies humoral responses with broad neutralization activity. Vaccine 29(32): 5250-5259. (*Both authors contributed equally to this work)
  21. Buzon, M. J.*, Codoner, F. M.*, Frost, S. D., Pou, C., Puertas, M. C., Massanella, M., Dalmau, J., Llibre, J. M., Stevenson, M., Blanco, J., Clotet, B., Paredes, R. and Martinez-Picado, J. (2011). Deep molecular characterization of HIV-1 dynamics under suppressive HAART. PLoS Pathog 7(10): e1002314.
  22. Massanella, M., Tural, C., Papagno, L., Garcia, E., Jou, A., Bofill, M., Autran, B., Clotet, B. and Blanco, J. (2010). Changes in T-cell subsets in HIV-HCV-coinfected patients during pegylated interferon-alpha2a plus ribavirin treatment. Antivir Ther 15(3): 333-342.
  23. Massanella, M.*, Negredo, E.*, Perez-Alvarez, N., Puig, J., Ruiz-Hernandez, R., Bofill, M., Clotet, B. and Blanco, J. (2010). CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART. AIDS 24(7): 959-968. (*Both authors contributed equally to this work)
  24. Negredo, E.*, Massanella, M.*, Puig, J., Perez-Alvarez, N., Gallego-Escuredo, J. M., Villarroya, J., Villarroya, F., Molto, J., Santos, J. R., Clotet, B. and Blanco, J. (2010). Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications. Clin Infect Dis 50(9): 1300-1308. (*Both authors contributed equally to this work)
  25. Buzon, M. J.*, Massanella, M.*, Llibre, J. M., Esteve, A., Dahl, V., Puertas, M. C., Gatell, J. M., Domingo, P., Paredes, R., Sharkey, M., Palmer, S., Stevenson, M., Clotet, B., Blanco, J. and Martinez-Picado, J. (2010). HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nat Med 16(4): 460-465. (*Both authors contributed equally to this work)
  26. Massanella, M.*, Puigdomenech, I.*, Cabrera, C., Fernandez-Figueras, M. T., Aucher, A., Gaibelet, G., Hudrisier, D., Garcia, E., Bofill, M., Clotet, B. and Blanco, J. (2009). Antigp41 antibodies fail to block early events of virological synapses but inhibit HIV spread between T cells. AIDS 23(2): 183-188. (*Both authors contributed equally to this work)
  27. Puigdomenech, I., Massanella, M., Cabrera, C., Clotet, B. and Blanco, J. (2009). On the steps of cell-to-cell HIV transmission between CD4 T cells. Retrovirology 6: 89.
  28. Puigdomenech, I., Massanella, M., Izquierdo-Useros, N., Ruiz-Hernandez, R., Curriu, M., Bofill, M., Martinez-Picado, J., Juan, M., Clotet, B. and Blanco, J. (2008). HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4. Retrovirology 5: 32.

Reviews

  1. Gianella, S., Massanella, M., Wertheim, J. O. and Smith, D. M. (2015). The Sordid Affair Between Human Herpesvirus and HIV. J Infect Dis.
  2. Massanella, M., Martinez-Picado, J. and Blanco, J. (2013). Attacking the HIV reservoir from the immune and viral perspective. Current HIV/AIDS Reports 10(1): 33-41.
  3. Massanella, M., Negredo, E., Clotet, B. and Blanco, J. (2013). Immunodiscordant responses to HAART--mechanisms and consequences. Expert Rev Clin Immunol 9(11): 1135-1149.
  4. Massanella, M. and Blanco, J. (2011). Apoptosis en la infección por VIH. AIDS Cyber J  14(6). (Review)
2 Protocols published
Quantification of Total and 2-LTR (Long terminal repeat) HIV DNA, HIV RNA and Herpesvirus DNA in PBMCs
Authors:  Marta Massanella, Sara Gianella, Steven M. Lada, Douglas D. Richman and Matthew C. Strain, date: 06/05/2015, view: 3822, Q&A: 0
Almost all individuals infected with human immunodeficiency virus (HIV) are also infected with cytomegalovirus (CMV) and Epstein Barr virus (EBV). The aims of our studies have included characterizing and measuring the latent HIV reservoir and ...
Quantification of HIV RNA and Human Herpesvirus DNA in Seminal Plasma
Authors:  Milenka V. Vargas-Meneses, Marta Massanella, Caroline C. Ignacio and Sara Gianella, date: 05/05/2015, view: 2850, Q&A: 0
Multiple viruses can co-infect the genital tract, modifying the immunologic and virologic milieu and possibly playing a role in viral transmission and pathogenesis. The aim of our studies has been to understand the complex relationships between ...