Education
Ph.D. in Molecular and Cell Biology, Oxford University, UK, 1996
Current position
Associate Professor of Cancer Biology, School of Medicine, University of Leeds
Publications (since 2009)
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Hayes, J., Thygesen, H., Bellamy, C., Droop, A., Boissinot, M., Hughes, T. A., Westhead, D., Alder, J. E., Shaw, L. and Short, S. C. (2014). Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature. Mol Oncol.
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Langlands, F. E., Dodwell, D., Hanby, A. M., Horgan, K., Millican-Slater, R. A., Speirs, V., Verghese, E. T., Smith, L. and Hughes, T. A. (2014). PSMD9 expression predicts radiotherapy response in breast cancer. Mol Cancer 13: 73.
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Verghese, E. T., Drury, R., Green, C. A., Holliday, D. L., Lu, X., Nash, C., Speirs, V., Thorne, J. L., Thygesen, H. H., Zougman, A., Hull, M. A., Hanby, A. M. and Hughes, T. A. (2013). MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion. J Pathol 231(3): 388-399.
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Kim, B., Fatayer, H., Hanby, A. M., Horgan, K., Perry, S. L., Valleley, E. M., Verghese, E. T., Williams, B. J., Thorne, J. L. and Hughes, T. A. (2013). Neoadjuvant chemotherapy induces expression levels of breast cancer resistance protein that predict disease-free survival in breast cancer. PLoS One 8(5): e62766.
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Tiernan, J. P., Perry, S. L., Verghese, E. T., West, N. P., Yeluri, S., Jayne, D. G. and Hughes, T. A. (2013). Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. Br J Cancer 108(3): 662-667.
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Cookson, V. J., Bentley, M. A., Hogan, B. V., Horgan, K., Hayward, B. E., Hazelwood, L. D. and Hughes, T. A. (2012). Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours. Cell Oncol (Dordr) 35(4): 301-308.
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Drury, R., Verghese, E. T. and Hughes, T. A. (2012). The roles of microRNAs in sarcomas. J Pathol 227(4): 385-391.
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Tiernan, J. P., Ansari, I., Hirst, N. A., Millner, P. A., Hughes, T. A. and Jayne, D. G. (2012). Intra-operative tumour detection and staging in colorectal cancer surgery. Colorectal Dis 14(9): e510-520.
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Verghese, E. T., Shenoy, H., Cookson, V. J., Green, C. A., Howarth, J., Partanen, R. H., Pollock, S., Waterworth, A., Speirs, V., Hughes, T. A. and Hanby, A. M. (2011). Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear localized beta-catenin in carcinoma-associated fibroblasts. Histopathology 59(4): 609-618.
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Hogan, B. V., Peter, M. B., Achuthan, R., Beaumont, A. J., Langlands, F. E., Shakes, S., Wood, P. M., Shenoy, H. G., Orsi, N. M., Horgan, K., Carter, C. R. and Hughes, T. A. (2011). Perioperative reductions in circulating lymphocyte levels predict wound complications after excisional breast cancer surgery. Ann Surg 253(2): 360-364.
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Satheesha, S., Cookson, V. J., Coleman, L. J., Ingram, N., Madhok, B., Hanby, A. M., Suleman, C. A., Sabine, V. S., Macaskill, E. J., Bartlett, J. M., Dixon, J. M., McElwaine, J. N. and Hughes, T. A. (2011). Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer. Mol Cancer 10: 19.
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Hogan, B. V., Peter, M. B., Shenoy, H. G., Horgan, K. and Hughes, T. A. (2011). Surgery induced immunosuppression. Surgeon 9(1): 38-43.
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Madhok, B. M., Yeluri, S., Perry, S. L., Hughes, T. A. and Jayne, D. G. (2011). Targeting glucose metabolism: an emerging concept for anticancer therapy. Am J Clin Oncol 34(6): 628-635.
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Smith, L., Coleman, L. J., Cummings, M., Satheesha, S., Shaw, S. O., Speirs, V. and Hughes, T. A. (2010). Expression of oestrogen receptor beta isoforms is regulated by transcriptional and post-transcriptional mechanisms. Biochem J 429(2): 283-290.
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Smith, L., Brannan, R. A., Hanby, A. M., Shaaban, A. M., Verghese, E. T., Peter, M. B., Pollock, S., Satheesha, S., Szynkiewicz, M., Speirs, V. and Hughes, T. A. (2010). Differential regulation of oestrogen receptor beta isoforms by 5' untranslated regions in cancer. J Cell Mol Med 14(8): 2172-2184.
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Al-Nakhle, H., Burns, P. A., Cummings, M., Hanby, A. M., Hughes, T. A., Satheesha, S., Shaaban, A. M., Smith, L. and Speirs, V. (2010). Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer. Cancer Res 70(11): 4778-4784.
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Madhok, B. M., Yeluri, S., Perry, S. L., Hughes, T. A. and Jayne, D. G. (2010). Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. Br J Cancer 102(12): 1746-1752.
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Smith, L., Speirs, V. and Hughes, T. A. (2010). Estrogen receptor regulation: don't forget translation. Breast Cancer Res Treat 121(1): 251-252.
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Coleman, L. J., Peter, M. B., Teall, T. J., Brannan, R. A., Hanby, A. M., Honarpisheh, H., Shaaban, A. M., Smith, L., Speirs, V., Verghese, E. T., McElwaine, J. N. and Hughes, T. A. (2009). Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity. Br J Cancer 100(9): 1393-1399.