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Coauthors
Yong-Xiang Wang King’s Lab, Shanghai Jiao Tong University School of Pharmacy, China
1 protocol

Shuai Ma King’s Lab, Shanghai Jiao Tong University School of Pharmacy, China
1 protocol

Meng Xu King’s Lab, Shanghai Jiao Tong University School of Pharmacy, China
1 protocol

Yuan Chen Shanghai Jiao Tong University School of Pharmacy
1 protocol

Reviewer
Nian Gong
  • Shanghai Jiao Tong University School of Pharmacy
Research focus
  • Neuroscience
Contributions
  • 1 Author merit
  • 3 Reviewer merit

Education

Ph.D. in Pharmacology, Shanghai Jiao Tong University, Shanghai, China, 2013

Current position

Post-Doctoral Research Fellow, Department of Anesthesiology & Perioperative Care, University of California, Irvine (2014-present)

Publications

  1. Gong, N., Huang, Q., Chen, Y., Xu, M., Ma, S. and Wang, Y. X. (2014). Pain Assessment Using the Rat and Mouse Formalin Tests. Bio-protocol 4(21): e1288.
  2. Fan, H., Gong, N., Li, T. F., Ma, A. N., Wu, X. Y., Wang, M. W. and Wang, Y. X. (2014). Nonpeptidic GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating beta-endorphin release from spinal microglia. Br J Pharmacol. (Epub ahead of print)
  3. Zhu, B., Gong, N., Fan, H., Peng, C. S., Ding, X. J., Jiang, Y. and Wang, Y. X. (2014). Lamiophlomis rotata, an Orally Available Tibetan Herbal Painkiller, Specifically Reduces Pain Hypersensitivity States through the Activation of Spinal Glucagon-like Peptide-1 Receptors. Anesthesiology 121(4): 835-851.
  4. Gong, N., Fan, H., Ma, A. N., Xiao, Q. and Wang, Y. X. (2014). Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors. Neuropharmacology 84: 31-45.
  5. Gong, N., Xiao, Q., Zhu, B., Zhang, C. Y., Wang, Y. C., Fan, H., Ma, A. N. and Wang, Y. X. (2014). Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. J Neurosci 34(15): 5322-5334.
  6. Gong, N., Li, X. Y., Xiao, Q. and Wang, Y. X. (2014). Identification of a novel spinal dorsal horn astroglial D-amino acid oxidase-hydrogen peroxide pathway involved in morphine antinociceptive tolerance. Anesthesiology 120(4): 962-975.
  7. Wang, Y. C., Lu, J. M., Jin, H. Z., Ma, A. N., Zhang, J. Y., Gong, N., Xiao, Q., Zhu, B., Lv, Y. F., Yu, N., Zhang, W. D. and Wang, Y. X. (2014). Beneficial effects of natural Jeju groundwaters on lipid metabolism in high-fat diet-induced hyperlipidemic rats. Nutr Res Pract 8(2): 165-171.
  8. Zhang, J. Y., Gong, N., Huang, J. L., Guo, L. C. and Wang, Y. X. (2013). Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal alpha3 glycine receptors. Pain 154(11): 2452-2462.
  9. Wei, H., Gong, N., Huang, J. L., Fan, H., Ma, A. N., Li, X. Y., Wang, Y. X. and Pertovaara, A. (2013). Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat. Pharmacol Biochem Behav 111: 30-36.
  10. Ma, A. N., Gong, N., Lu, J. M., Huang, J. L., Hao, B., Guo, Y., Zhong, J., Xu, Y., Chang, J. and Wang, Y. X. (2013). Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals. J Mater Sci Mater Med 24(3): 803-809.
  11. Gong, N., Wang, Y. C., Wang, H. L., Ma, A. N., Hashimoto, K. and Wang, Y. X. (2012). Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia. Neuropharmacology 63(3): 460-468.
  12. Wang, Y. X., Gong, N., Xin, Y. F., Hao, B., Zhou, X. J. and Pang, C. C. (2012). Biological implications of oxidation and unidirectional chiral inversion of D-amino acids. Curr Drug Metab 13(3): 321-331.
  13. Lu, J. M., Gong, N., Wang, Y. C. and Wang, Y. X. (2012). D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. Br J Pharmacol 165(6): 1941-1955.
  14. Wei, H., Huang, J.-L., Hao, B., Wang, Y.-C., Nian, G., Ma, A.-N., Li, X.-Y., Wang, Y.-X. and Pertovaara, A. (2011). Intrathecal administration of antioxidants attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat. Scandinavian Journal of Pain 2(2): 64-69.
  15. Gong, N., Ma, A. N., Zhang, L. J., Luo, X. S., Zhang, Y. H., Xu, M. and Wang, Y. X. (2011). Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity. Br J Pharmacol 163(2): 399-412.
  16. Gong, N., Gao, Z. Y., Wang, Y. C., Li, X. Y., Huang, J. L., Hashimoto, K. and Wang, Y. X. (2011). A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats. J Pharmacol Exp Ther 336(1): 282-293.
  17. Xin, Y. F., Li, X., Hao, B., Gong, N., Sun, W. Q., Konno, R. and Wang, Y. X. (2010). Indispensable but insufficient role of renal D-amino acid oxidase in chiral inversion of NG-nitro-D-arginine. Chem Biodivers 7(6): 1413-1423.
  18. Zhang, W. B., Gong, N. and Wang, Y. X. (2010). Renal SGLT2 inhibitors: a new type of oral anti-hyperglycemia drugs. Sheng Li Ke Xue Jin Zhan 41(6): 453-456.
1 Protocol published
Pain Assessment Using the Rat and Mouse Formalin Tests
Authors:  Nian Gong, Qian Huang, Yuan Chen, Meng Xu, Shuai Ma and Yong-Xiang Wang, date: 11/05/2014, view: 9052, Q&A: 0
The formalin test was originally developed by Dubuisson and Dennis (1977), and has since been extensively used to assess pain-related responses. Rats and mice are the most frequently used animal models, though other species including cats, rabbits, ...