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Coauthors
Jennifer Philips Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, USA
1 protocol
Coreviewers
Andrea Introini Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm Sweden
8 protocols

Elizabeth Clarke Center for Health Research, Kaiser Permanente
5 protocols

Fabienne Fiesel Mayo Clinic, Department of Neuroscience, USA
1 protocol

Fanglian He Department of Biology, University of Pennsylvania, USA
205 protocols

Alka Mehra
  • Department of Allergy and Infectious Diseases, Institute of Genomics and Integrative Biology, Mall Road, Delhi, India
Research focus
  • Immunology
Contributions
  • 2 Author merit
  • 7 Reviewer merit
  • 7 Editor merit

Education

Ph.D. in Molecular Parasitology, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 2006

Current position

Young Scientist, Department of Science and Technology (DST), Allergy and Infectious Disease Division, Institute of Genomics and Integrative Biology (IGIB), Delhi, India (11/2015- till date)

Publications

  1. Mehra, A. (2015). Microbial CRISPR-Cas system: From bacterial immunity to next-generation antimicrobials. Microbial Factories. Springer Volume 2, Chapter 14. Pages 217- 234.
  2. Mehra, A. (2014). Phagolysosomal trafficking assay. Bio-protocol 4(13): e1163.
  3. Mehra, A. and Philips, J. A. (2014). Analysis of mycobacterial protein secretion. Bio-protocol 4(12): e1159.
  4. Siegrist, M. S., Steigedal, M., Ahmad, R., Mehra, A., Dragset, M. S., Schuster, B. M., Philips, J. A., Carr, S. A. and Rubin, E. J. (2014). Mycobacterial Esx-3 requires multiple components for iron acquisition. MBio 5(3): e01073-01014.
  5. Mehra, A.*, Zahra, A.*, Thompson, V., Sirisaengtaksin, N., Wells, A., Porto, M., Koster, S., Penberthy, K., Kubota, Y., Dricot, A., Rogan, D., Vidal, M., Hill, D. E., Bean, A. J. and Philips, J. A. (2013). Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking. PLoS Pathog 9(10): e1003734. (*Equal contribution)
  6. Singh, Y., Kaul, V., Mehra, A., Chatterjee, S., Tousif, S., Dwivedi, V. P., Suar, M., Van Kaer, L., Bishai, W. R. and Das, G. (2013). Mycobacterium tuberculosis controls microRNA-99b (miR-99b) expression in infected murine dendritic cells to modulate host immunity. J Biol Chem 288(7): 5056-5061.
  7. Juranek, J. K., Kothary, P., Mehra, A., Hays, A., Brannagan, T. H., 3rd and Schmidt, A. M. (2013). Increased expression of the receptor for advanced glycation end-products in human peripheral neuropathies. Brain Behav 3(6): 701-709.
  8. Mehra, A., Bhattacharya, S. and Bhattacharya, A. (2007). Identification and functional characterization of a novel lysine-rich protein from Entamoeba histolytica. American Journal of Biochemistry and Biotechnology 3(4): 193-198.
  9. Mehra, A., Fredrick, J., Petri, W. A., Jr., Bhattacharya, S. and Bhattacharya, A. (2006). Expression and function of a family of transmembrane kinases from the protozoan parasite Entamoeba histolytica. Infect Immun 74(9): 5341-5351.
  10. Arya, R., Mehra, A., Bhattacharya, S., Vishwakarma, R. A. and Bhattacharya, A. (2003). Biosynthesis of Entamoeba histolytica proteophosphoglycan in vitro. Mol Biochem Parasitol 126(1): 1-8.
2 Protocols published
Phagolysosomal Trafficking Assay
Author:  Alka Mehra, date: 07/05/2014, view: 5733, Q&A: 0
Phagolysosomal trafficking is an important innate defense pathway that clears microbes by delivering them to lysosomes, the degradative compartment of the cell. Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, subverts ...
Analysis of Mycobacterial Protein Secretion
Authors:  Alka Mehra and Jennifer A. Philips, date: 06/20/2014, view: 4812, Q&A: 0
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Analysis of proteins secreted by Mtb has been of interest to the field of tuberculosis research since certain secreted proteins interact with the host to promote ...
7 Protocols reviewed
Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice
Authors:  Matilda F. Chan and Zena Werb, date: 07/05/2015, view: 3232, Q&A: 0
The accessibility and transparency of the cornea makes it a good tissue model for monitoring immunological responses using in vivo real time imaging analysis (Lee et al., 2010; Tan et al., 2013). These corneal qualities ...
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Animal Models of Corneal Injury
Authors:  Matilda F. Chan and Zena Werb, date: 07/05/2015, view: 2648, Q&A: 0
The cornea is an excellent model system to use for the analysis of wound repair because of its accessibility, lack of vascularization, and simple anatomy. Corneal injuries may involve only the superficial epithelial layer or may penetrate deeper to ...
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7 Protocols edited
In vitro Detection of Neutrophil Traps and Post-attack Cell Wall Changes in Candida Hyphae
Authors:  Alex Hopke and Robert T. Wheeler, date: 04/05/2017, view: 1107, Q&A: 0
In this protocol we describe how to visualize neutrophil extracellular traps (NETs) and fungal cell wall changes in the context of the coculture of mouse neutrophils with fungal hyphae of Candida albicans. These protocols are easily ...
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Activity-based Pull-down of Proteolytic Standard and Immunoproteasome Subunits
Activity-based probes (ABP) are small organic molecules that irreversibly bind to the active center of a specific enzyme family and may be coupled to a fluorophore or an affinity tag (Li et al., 2013). Here, we describe a method to ...
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