Petra Nilsson Immunology Section, Lund University, Sweden
1 protocol

Emma Persson Immunology Section, Lund University, Sweden
1 protocol

Heli Uronen-Hansson Immunology Section, Lund University, Sweden
1 protocol

William Agace
  • Immunology Section, Lund University, Sweden
  • 1 Author merit


Ph.D. in Mucosal Immunolog, Lund University, Sweden, 1996

Current position

Professor, Section of Immunology and Vaccinology, Veterinary Institute, Danish Technical University, Denmark (2013-present)
Professor, Head, Immunology Section, Lund University, Sweden (2006-present)


Peer reviewed original articles and reviews in scientific journals (since 2008)

  1. Mowat, A. M. and Agace, W. W. Immunological compartmentalization with gut microenvironments. Nature Reviews in Immunology (Commissioned and under preparation) (IF 33)
  2. Thiesen, S., Janciauskiene, S., Uronen-Hansson, H., Agace, W., Hogerkorp, C. M., Spee, P., Hakansson, K. and Grip, O. (2014). CD14hiHLA-DRdim macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease. J Leukoc Biol 95(3): 531-541. (IF 5)
  3. Persson, E. K., Scott, C. L., Mowat, A. M. and Agace, W. W. (2013). Dendritic cell subsets in the intestinal lamina propria: ontogeny and function. Eur J Immunol 43(12): 3098-3107. (IF 5)
  4. Persson, E. K., Uronen-Hansson, H., Semmrich, M., Rivollier, A., Hagerbrand, K., Marsal, J., Gudjonsson, S., Hakansson, U., Reizis, B., Kotarsky, K. and Agace, W. W. (2013). IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity 38(5): 958-969. (IF 21.6)
  5. Marsal, J. and Agace, W. W. (2012). Targeting T-cell migration in inflammatory bowel disease. J Intern Med 272(5): 411-429. (IF 5.5)
  6. Bain, C. C., Scott, C. L., Uronen-Hansson, H., Gudjonsson, S., Jansson, O., Grip, O., Guilliams, M., Malissen, B., Agace, W. W. and Mowat, A. M. (2013). Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors. Mucosal Immunol 6(3): 498-510. (IF 7)
  7. Agace, W. W. and Persson, E. K. (2012). How vitamin A metabolizing dendritic cells are generated in the gut mucosa. Trends Immunol 33(1): 42-48. (IF 10.4)
  8. Sitnik, K. M., Kotarsky, K., White, A. J., Jenkinson, W. E., Anderson, G. and Agace, W. W. (2012). Mesenchymal cells regulate retinoic acid receptor-dependent cortical thymic epithelial cell homeostasis. J Immunol 188(10): 4801-4809. (IF 5.8)
  9. Poulin, L. F., Reyal, Y., Uronen-Hansson, H., Schraml, B. U., Sancho, D., Murphy, K. M., Hakansson, U. K., Moita, L. F., Agace, W. W., Bonnet, D. and Reis e Sousa, C. (2012). DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood 119(25): 6052-6062. (IF 9.9)
  10. Semmrich, M., Plantinga, M., Svensson-Frej, M., Uronen-Hansson, H., Gustafsson, T., Mowat, A. M., Yrlid, U., Lambrecht, B. N. and Agace, W. W. (2012). Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses. Mucosal Immunol 5(2): 150-160. (IF 7)
  11. Jaensson-Gyllenback, E., Kotarsky, K., Zapata, F., Persson, E. K., Gundersen, T. E., Blomhoff, R. and Agace, W. W. (2011). Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells. Mucosal Immunol 4(4): 438-447. (IF 7)
  12. Suzuki, K., Maruya, M., Kawamoto, S., Sitnik, K., Kitamura, H., Agace, W. W. and Fagarasan, S. (2010). The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity 33(1): 71-83. (IF 21.6)
  13. Kotarsky, K., Sitnik, K. M., Stenstad, H., Kotarsky, H., Schmidtchen, A., Koslowski, M., Wehkamp, J. and Agace, W. W. (2010). A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa. Mucosal Immunol 3(1): 40-48. (IF 7)
  14. Persson, E. K., Jaensson, E. and Agace, W. W. (2010). The diverse ontogeny and function of murine small intestinal dendritic cell/macrophage subsets. Immunobiology 215(9-10): 692-697. (IF 3.2)
  15. Schulz, O., Jaensson, E., Persson, E. K., Liu, X., Worbs, T., Agace, W. W. and Pabst, O. (2009). Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 206(13): 3101-3114. (Joint senior author) (IF 13.9)
  16. Withers, D. R., Jaensson, E., Gaspal, F., McConnell, F. M., Eksteen, B., Anderson, G., Agace, W. W. and Lane, P. J. (2009). The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals. J Immunol 183(8): 5079-5084. (IF 5.8)
  17. van de Pavert, S. A., Olivier, B. J., Goverse, G., Vondenhoff, M. F., Greuter, M., Beke, P., Kusser, K., Hopken, U. E., Lipp, M., Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W. W., Randall, T. D., de Jonge, W. J. and Mebius, R. E. (2009). Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol 10(11): 1193-1199. (IF 26)
  18. Andersson, D., Kotarsky, K., Wu, J., Agace, W. and Duan, R. D. (2009). Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model. Dig Dis Sci 54(7): 1440-1448. (IF 2.1)
  19. Agace, W. W. (2008). T-cell recruitment to the intestinal mucosa. Trends Immunol 29(11): 514-522. (IF 10.4)
  20. Rolf, J., Berntman, E., Stenstrom, M., Smith, E. M., Mansson, R., Stenstad, H., Yamagata, T., Agace, W., Sigvardsson, M. and Cardell, S. L. (2008). Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets. Mol Immunol 45(9): 2607-2620. (IF 2.9)
  21. Monteleone, I., Platt, A. M., Jaensson, E., Agace, W. W. and Mowat, A. M. (2008). IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function. Eur J Immunol 38(6): 1533-1547. (IF 5)
  22. Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J. L., Berg, P. L., Davidsson, T., Powrie, F., Johansson-Lindbom, B. and Agace, W. W. (2008). Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med 205(9): 2139-2149. (IF 13.9)
  23. Svensson, M., Marsal, J., Uronen-Hansson, H., Cheng, M., Jenkinson, W., Cilio, C., Jacobsen, S. E., Sitnicka, E., Anderson, G. and Agace, W. W. (2008). Involvement of CCR9 at multiple stages of adult T lymphopoiesis. J Leukoc Biol 83(1): 156-164. (IF 5)
  24. Svensson, M., Johansson-Lindbom, B., Zapata, F., Jaensson, E., Austenaa, L. M., Blomhoff, R. and Agace, W. W. (2008). Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8+ T cells. Mucosal Immunol 1(1): 38-48. (IF 7)

Non-peer reviewed publications and book chapters (since 2000)

  1. Mihak, Z., Agace, W. and Luster, A. (2013). Lymphocyte trafficking to mucosal tissues. In: Strober, W., Charoutre, H., Kellsall, B. (eds). Mucosal Immunity. Elsevier publishers. (In press)
  2. Agace, W. and O. Pabst. (2012). Lymphocyte Trafficking from Inductive Sites to Effector Sites. In: Smith, P. Blumberg, R. and MacDonald, T. (eds). Principles in Mucosal Immunology. Garland Publishers, Chapter 14. 205-18.
  3. Agace, W. (2010). Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunol. Lett. 128(1):21-23.
  4. Agace, W. and Homey, B. (2006). Lymphocyte homing to peripheral epithelial sites. In: B. Moser (ed). Chemokine Biology: Basic Research and Clinical Application (Volume 1). Series "Progress in Inflammation Research. Basel, 35-58.
  5. Johansson-Lindbom, B., and Agace, W. (2004). Vitamin A helps gut T cells find their way in the dark. Nature Medicine 10 (12) 1300-01.
  6. Svensson, M., Johansson-Lindbom, B., and Agace, W. (2004). Selective generation of gut tropic T cells in gut-associated lymphoid tissue: requirement for GALT dendritic cells and adjuvant. In: Weiner, H. L., Mayer, L. and Strober, W. (eds). Oral Tolerance: New Insights and prospects for Clinical application. Annals of the New York Academy of Sciences, Volume 1029. 405-08.
  7. Ericsson, A., Svensson, M., Arya, A., and Agace, W. (2004). CCL25 enhances CD103 -mediated lymphocyte adhesion to E-cadherin. CD103 on intestinal intraepithelial lymphocytes. In: Weiner, H. L., Mayer, L. and Strober, W. (eds). Oral Tolerance: New Insights and prospects for Clinical application. Annals of the New York Academy of Sciences, Volume 1029.334-37.
  8. Wullt, B., Agace, W., and Månsson, W. (2004). Bacteriuria in patients with reconstructed lower urinary tracts. World J Urol 22(s): 186-95.
  9. Agace, W. and B. Johansson-Lindbom. (2004). GALT dendritic cells drive the generation of gut tropic effector T cells. Mucosal Immunology Update (MIU) 12 (1): 6-8.
1 Protocol published
Isolation of Cells from Human Intestinal Tissue
Authors:  Heli Uronen-Hansson, Emma Persson, Petra Nilsson and William Agace, date: 04/05/2014, view: 6170, Q&A: 0
The intestinal lamina propria contains a dense network of T cells, dendritic cells (DCs) and macrophages, which play an important role in local innate and adaptive immune responses. We have recently identified distinct subsets of DCs (Persson et al. ...