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Coauthors
Marzia Fumagalli The FIRC Institute for Molecular Oncology, IFOM, Italy
2 protocols

Francesca Rossiello The FIRC Institute for Molecular Oncology, IFOM, Italy
2 protocols

Fabrizio d’Adda di Fagagna
  • The FIRC Institute for Molecular Oncology, IFOM, Italy
  • 2 Author merit

Education

Ph.D. in Molecular Genetics (HIV-1 transcription), International School for Advanced Studies (ISAS-SISSA), Trieste, Italy, 1995

Current position

Tenured Principal Investigator, IFOM Foundation, Milan, Italy (2009-present)
Group leader at the Molecular Genetic Institute (IGM) of the National Research Council, Pavia, Italy (2012-present)

Publications

  1. Francia, S., Michelini, F., Saxena, A., Tang, D., de Hoon, M., Anelli, V., Mione, M., Carninci, P. and d'Adda di Fagagna, F. (2012). Site-specific DICER and DROSHA RNA products control the DNA-damage response. Nature 488(7410): 231-235.
    Citations: 22
    Faculty of 1000: Highlighted as “Must read”. FFa=8
  2. Fumagalli, M., Rossiello, F., Clerici, M., Barozzi, S., Cittaro, D., Kaplunov, J. M., Bucci, G., Dobreva, M., Matti, V., Beausejour, C. M., Herbig, U., Longhese, M. P. and d'Adda di Fagagna, F. (2012). Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol 14(4): 355-365.
    Commented by P. Adams in the same issue and by J.J. Jacobs in NRMCB. Highlighted in Nature Reviews Molecular Cell Biology.Highlighted in Science.
    Citations: 30
  3. d'Adda di Fagagna, F. (2008). Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer 8(7): 512-522.
    Citations: 177
  4. Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre, M., Nuciforo, P. G., Bensimon, A., Maestro, R., Pelicci, P. G. and d'Adda di Fagagna, F. (2006). Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444(7119): 638-642.
    Citations: 666
    Faculty of 1000: Highlighted as “Must read”. FFa=9
  5. d'Adda di Fagagna, F., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., Von Zglinicki, T., Saretzki, G., Carter, N. P. and Jackson, S. P. (2003). A DNA damage checkpoint response in telomere-initiated senescence. Nature 426(6963): 194-198.
    Citations: 1160
    Faculty of 1000: Highlighted as “Must read”. FFa=8

    Citation records are according to Google Scholar and Faculty of 1000 on March 2013

2 Protocols published
ImmunoFISH for Mice and Baboons Frozen Sections
Authors:  Francesca Rossiello, Marzia Fumagalli and Fabrizio d’Adda di Fagagna, date: 12/20/2013, view: 3425, Q&A: 0
This protocol is optimized for immunoFISH staining of OCT section of mouse tissues. It combines immunofluorescence for DNA damage response factors (e.g. 53BP1) (Le et al., 2010) and FISH against telomeric DNA.
ImmunoFISH for Adherent Cultured Mammalian Cells
Authors:  Francesca Rossiello, Marzia Fumagalli and Fabrizio d’Adda di Fagagna, date: 12/20/2013, view: 4316, Q&A: 0
This protocol is optimized for immunoFISH staining of adherent cultured mammalian cells. It combines immunofluorescence for DNA damage response factors (e.g. 53BP1) and FISH against telomeric DNA.