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Coauthors
Magdalene Michael Randall Division of Cell and Molecular Biophysics, King’s College London, Guy’s Campus, UK
2 protocols

Xuan Liang Divisions of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, Australia
2 protocols

Rashmi Priya Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, Australia
1 protocol
Coreviewers
Andrea Introini Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm Sweden
8 protocols

Jingli Cao Department of Cell Biology, Duke University Medical Center
7 protocols

Jyotiska Chaudhuri The Buck Institute for Research on Aging
17 protocols

Kristina Aguilera UCLA
2 protocols

Guillermo Gomez
  • Faculty, Centre for Cancer Biology, University of South Australia, Adelaide SA, Australia
Research focus
  • Cancer biology
Contributions
  • 3 Author merit
  • 3 Reviewer merit
  • 4 Editor merit

Education

PhD, National University of Cordoba, 2008

Lab information

Guillermo Gomez's lab

Research interest: Physical forces are a key determinant of tissue architecture controlling also cellular behaviours that range from the differentiation of stem cells to cell transformation and cancer invasion. We have made significant progress in understanding the mechanisms involved in capacity of the cells to generate forces and the regulation of epithelial organization. We now are using this knowledge to understand how dysregulation of tissue mechanics contributes to the loss of tissue architecture and organ function.
https://ccb.unisa.edu.au/research/laboratories/Tissue_Architecture_and_Organ_Function_Laboratory/

Publications

Selected publications
1. Priya R, Liang X, Teo JL, Duszyc K., Yap AS and Gomez GA*. 2017. ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA mediated contractility at the epithelial zonula adherens. Molecular Biology of the Cell 2017. 28(1):12-20. *Corresponding Author
2. Acharya BR, Wu SK, Lieu ZZ, Parton RG, Grill SW, Bershadsky AD, Gomez GA, Yap AS. 2017. Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility. Cell Reports. 18 (12), 2854-2867
3. Priya R*, Gomez GA*, Budnar S, Acharya BR, Czirok A, Yap AS, Neufeld Z. 2017. Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. PLoS Computational Biology 13 (3), e1005411 *Co-first authors
4. Coburn L, Lopez H, Caldwell BJ, Moussa E, Yap C, Priya R, Noppe A, Roberts AP, Lobaskin V, Yap AS, Neufeld Z, Gomez GA*. 2016. Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determines the pattern of junctional tension in epithelial cell aggregates. Molecular Biology of the Cell 27(22):3436-3448 *Corresponding author
5. Michael M, Meiring JC, Acharya BR, Matthews DR, Verma S, Han SP, Hill MM, Parton RG, Gomez GA, Yap AS. 2016. Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions. Developmental Cell. Apr 4;37(1):58-71.
6. Priya R, Gomez GA*, Budnar S, Verma S, Cox HL, Hamilton NA, Yap AS*. 2015. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nature Cell Biology 17(10):1282-93. *Corresponding authors
7. Gomez GA*, McLachlan RW, Wu SK, Caldwell BJ, Moussa E, Verma S, Bastiani M, Priya R, Parton RG, Gaus K, Sap J, Yap AS*. 2015. An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions. Molecular Biology of the Cell. 26(7):1249-62.* Corresponding authors.
8. Caldwell BJ, Lucas C, Kee AJ, Gaus K, Gunning PW, Hardeman EC, Yap AS* and Gomez GA*. 2014. Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens. Cytoskeleton 71:663. *Corresponding Authors.
9. Wu SK, Gomez GA*, Michael M, Verma S, Cox HL, Lefevre JG, Parton RG, Hamilton NA, Neufeld Z, Yap AS*. 2014. Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia. Nature Cell Biology. 16(2):167-78. *Corresponding Authors.
10. Ratheesh A.*, Gomez GA*, Priya R, Verma S, Kovacs EM, Jiang K, Brown NH, Akhmanova A, Stehbens SJ, Yap AS. 2012. Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nature Cell Biology 14(8):818-28.* co-first author.

3 Protocols published
Measurement of Mechanical Tension at cell-cell junctions using two-photon laser ablation
Authors:  Xuan Liang, Magdalene Michael and Guillermo A. Gomez, date: 12/20/2016, view: 1363, Q&A: 0
The cortical actomyosin cytoskeleton is found in all non-muscle cells where a key function is to control mechanical force (Salbreux et al., 2012). When coupled to E-cadherin cell-cell adhesion, cortical actomyosin generates junctional ...
Analysis of Myosin II Minifilament Orientation at Epithelial Zonula Adherens
Authors:  Magdalene Michael, Xuan Liang and Guillermo A. Gomez, date: 12/05/2016, view: 1261, Q&A: 0
Non-muscle myosin II (NMII) form bipolar filaments, which bind F-actin to exert cellular contractility during physiological processes (Vicente-Manzanares et al., 2009). Using a combinatorial approach to fluorescently label both N- and ...
5 Protocols edited/reviewed
Analysis of Cancer Stromal Reaction Using an O-ring Co-culture Assay
Author:  Vivien Jane Coulson-Thomas, date: 02/20/2017, view: 1162, Q&A: 0
We have developed a 2D heterotypic co-culture technique between fibroblasts and cancer cells that enables the study of the stromal reaction. For such, stromal cells are seeded and cultured immediately around a tumour cell line, and the cells ...
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Vascular Smooth Muscle Cell Isolation and Culture from Mouse Aorta
Vascular smooth muscle cells (SMC) in the ascending thoracic aorta arise from neural crest cells, whereas SMCs in the descending aorta are derived from the presomitic mesoderm. SMCs play important roles in cardiovascular development and aortic ...
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