Thillai Sekar Department of Radiology, Stanford University School of Medicine, USA
1 protocol

Ramasamy Paulmurugan
  • Department of Radiology, Stanford University School of Medicine, USA
  • 1 Author merit


Ph.D. in Bio-medical Genetics (Molecular Virology), University of Madras, Madras, India, 1997

Current position

Assistant Professor, Department of Radiology, MIPS, Stanford University, Stanford, CA, USA

Publications (selected from 74 peer-reviewed publications)

  1. Paulmurugan, R., Tamrazi, A., Massoud, T. F., Katzenellenbogen, J. A. and Gambhir, S. S. (2011). In vitro and in vivo molecular imaging of estrogen receptor alpha and beta homo- and heterodimerization: exploration of new modes of receptor regulation. Mol Endocrinol 25(12): 2029-2040.
  2. Sekar, T. V., Dhanabalan, A. and Paulmurugan, R. (2011). Imaging cellular receptors in breast cancers: an overview. Curr Pharm Biotechnol 12(4): 508-527.
  3. Auer, V. J., Bucher, J., Schremmer-Danninger, E., Paulmurugan, R., Maechler, P., Reiser, M. F., Stangl, M. J. and Berger, F. (2011). Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats. Curr Pharm Biotechnol 12(4): 488-496.
  4. Ahn, B. C., Ronald, J. A., Kim, Y. I., Katzenberg, R., Singh, A., Paulmurugan, R., Ray, S., Hofmann, L. V. and Gambhir, S. S. (2011). Potent, tumor-specific gene expression in an orthotopic hepatoma rat model using a Survivin-targeted, amplifiable adenoviral vector. Gene Ther 18(6): 606-612.
  5. Gheysens, O., Chen, I. Y., Rodriguez-Porcel, M., Chan, C., Rasooly, J., Vaerenberg, C., Paulmurugan, R., Willmann, J. K., Deroose, C., Wu, J. and Gambhir, S. S. (2011). Non-invasive bioluminescence imaging of myoblast-mediated hypoxia-inducible factor-1 alpha gene transfer. Mol Imaging Biol 13(6): 1124-1132.
  6. Thakor, A. S., Paulmurugan, R., Kempen, P., Zavaleta, C., Sinclair, R., Massoud, T. F. and Gambhir, S. S. (2011). Oxidative stress mediates the effects of Raman-active gold nanoparticles in human cells. Small 7(1): 126-136.
  7. Fan-Minogue, H., Cao, Z., Paulmurugan, R., Chan, C. T., Massoud, T. F., Felsher, D. W. and Gambhir, S. S. (2010). Noninvasive molecular imaging of c-Myc activation in living mice. Proc Natl Acad Sci U S A 107(36): 15892-15897.
  8. Massoud, T. F., Paulmurugan, R. and Gambhir, S. S. (2010). A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography. Nat Med 16(8): 921-926.
  9. Chen, I. Y., Gheysens, O., Ray, S., Wang, Q., Padmanabhan, P., Paulmurugan, R., Loening, A. M., Rodriguez-Porcel, M., Willmann, J. K., Sheikh, A. Y., Nielsen, C. H., Hoyt, G., Contag, C. H., Robbins, R. C., Biswal, S., Wu, J. C. and Gambhir, S. S. (2010). Indirect imaging of cardiac-specific transgene expression using a bidirectional two-step transcriptional amplification strategy. Gene Ther 17(7): 827-838.
  10. Paulmurugan, R., Padmanabhan, P., Ahn, B. C., Ray, S., Willmann, J. K., Massoud, T. F., Biswal, S. and Gambhir, S. S. (2009). A novel estrogen receptor intramolecular folding-based titratable transgene expression system. Mol Ther 17(10): 1703-1711.
  11. Willmann, J. K., Paulmurugan, R., Rodriguez-Porcel, M., Stein, W., Brinton, T. J., Connolly, A. J., Nielsen, C. H., Lutz, A. M., Lyons, J., Ikeno, F., Suzuki, Y., Rosenberg, J., Chen, I. Y., Wu, J. C., Yeung, A. C., Yock, P., Robbins, R. C. and Gambhir, S. S. (2009). Imaging gene expression in human mesenchymal stem cells: from small to large animals. Radiology 252(1): 117-127.
  12. Ray, S., Paulmurugan, R., Patel, M. R., Ahn, B. C., Wu, L., Carey, M. and Gambhir, S. S. (2008). Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy. Mol Ther 16(11): 1848-1856.
  13. Paulmurugan, R., Tamrazi, A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. and Gambhir, S. S. (2008). A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action. Mol Endocrinol 22(7): 1552-1564.
  14. Paulmurugan, R. and Gambhir, S. S. (2007). Combinatorial library screening for developing an improved split-firefly luciferase fragment-assisted complementation system for studying protein-protein interactions. Anal Chem 79(6): 2346-2353.
  15. Paulmurugan, R. and Gambhir, S. S. (2006). An intramolecular folding sensor for imaging estrogen receptor-ligand interactions. Proc Natl Acad Sci U S A 103(43): 15883-15888.
  16. Paulmurugan, R., Umezawa, Y. and Gambhir, S. S. (2002). Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies. Proc Natl Acad Sci U S A 99(24): 15608-15613.
1 Protocol published
3H-Penciclovir (3H-PCV) Uptake Assay
Authors:  Thillai V Sekar and Ramasamy Paulmurugan, date: 09/05/2013, view: 3464, Q&A: 0
Thymidine Kinase from human Herpes simplex virus type 1 (HSV1-TK) in combination with specific substrate prodrug nucleotide analogue ganciclovir (GCV) has been widely used as suicidal therapeutic gene for cancer gene therapy. HSV1, and its ...