Sun-Hwa Lee
  • Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, USA
  • 1 Author merit


Ph.D., Department of Microbiology, Boston University School of Medicine, 2001

Current position

Principal Researcher, New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Korea


  1. Wong, L. Y., Brulois, K., Toth, Z., Inn, K. S., Lee, S. H., O'Brien, K., Lee, H., Gao, S. J., Cesarman, E., Ensser, A. and Jung, J. U. (2013). KSHV K4.2 immediate early gene product regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. J Virol.
  2. Wong, L.Y., Toth, Z., Brulois, K. F., Inn, K.S., Lee, S. H., Lee, H.R. and Jung, J. U. (2013). Molecular Mimicry by γ-2 Herpesviruses to Modulate Host Cell Signaling Pathways. Primates, Pathogens, and Evolution (Jessica F. Brinkworth, Ekaterina Pechenkinam), Springer, 38: 221-251.
  3. Lee, S. H., Toth, Z., Wong, L. Y., Brulois, K., Nguyen, J., Lee, J. Y., Zandi, E. and Jung, J. U. (2012). Novel Phosphorylations of IKKγ/NEMO. MBio 3(6): e00411-00412.
  4. Brulois, K. F., Chang, H., Lee, A. S., Ensser, A., Wong, L. Y., Toth, Z., Lee, S. H., Lee, H. R., Myoung, J., Ganem, D., Oh, T. K., Kim, J. F., Gao, S. J. and Jung, J. U. (2012). Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome clone. J Virol 86(18): 9708-9720.
  5. Sun-Hwa Lee, Stacy Lee and Jae U. Jung. 2012. Chapter 3. Virus-Mediated Cell Proliferation. pp. 45-80. Cancer Associated Viruses. Current Cancer Research. Robertson Erle S. (Ed.). Springer
  6. Kingston, D., Chang, H., Ensser, A., Lee, H. R., Lee, J., Lee, S. H., Jung, J. U. and Cho, N. H. (2011). Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation. J Virol 85(20): 10627-10638.
  7. Toth, Z., Maglinte, D. T., Lee, S. H., Lee, H. R., Wong, L. Y., Brulois, K. F., Lee, S., Buckley, J. D., Laird, P. W., Marquez, V. E. and Jung, J. U. (2010). Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog 6(7): e1001013.
  8. Lee, J. S., Li, Q., Lee, J. Y., Lee, S. H., Jeong, J. H., Lee, H. R., Chang, H., Zhou, F. C., Gao, S. J., Liang, C. and Jung, J. U. (2009). FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol 11(11): 1355-1362.
  9. Min, C. K., Bang, S. Y., Cho, B. A., Choi, Y. H., Yang, J. S., Lee, S. H., Seong, S. Y., Kim, K. W., Kim, S., Jung, J. U., Choi, M. S., Kim, I. S. and Cho, N. H. (2008). Role of amphipathic helix of a herpesviral protein in membrane deformation and T cell receptor downregulation. PLoS Pathog 4(11): e1000209.
  10. Garcia, M. I., Kaserman, J., Chung, Y. H., Jung, J. U. and Lee, S. H. (2007). Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction. J Virol 81(6): 2663-2674.
  11. Cho, I. R., Jeong, S., Jhun, B. H., An, W. G., Lee, B., Kwak, Y. T., Lee, S. H., Jung, J. U. and Chung, Y. H. (2007). Activation of non-canonical NF-kappaB pathway mediated by STP-A11, an oncoprotein of Herpesvirus saimiri. Virology 359(1): 37-45.
  12. Lee, B. S., Lee, S. H., Feng, P., Chang, H., Cho, N. H. and Jung, J. U. (2005). Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome. J Virol 79(19): 12173-12184.
  13. Cho, N. H., Feng, P., Lee, S. H., Lee, B. S., Liang, X., Chang, H. and Jung, J. U. (2004). Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri. J Exp Med 200(5): 681-687.
  14. Irani, V. R., Lee, S. H., Eckstein, T. M., Inamine, J. M., Belisle, J. T. and Maslow, J. N. (2004). Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant. Ann Clin Microbiol Antimicrob 3: 18.
  15. Lee, S. H., Chung, Y. H., Cho, N. H., Gwack, Y., Feng, P. and Jung, J. U. (2004). Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein. Mol Cell Biol 24(12): 5369-5382.
  16. Chung, Y. H., Cho, N. H., Garcia, M. I., Lee, S. H., Feng, P. and Jung, J. U. (2004). Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein. J Virol 78(12): 6489-6497.
  17. Feng, P., Scott, C., Lee, S. H., Cho, N. H. and Jung, J. U. (2004). Manipulation of apoptosis by herpes viruses (Kaposi's sarcoma pathogenesis). Prog Mol Subcell Biol 36: 191-205.
  18. Maslow, J. N., Irani, V. R., Lee, S. H., Eckstein, T. M., Inamine, J. M. and Belisle, J. T. (2003). Biosynthetic specificity of the rhamnosyltransferase gene of Mycobacterium avium serovar 2 as determined by allelic exchange mutagenesis. Microbiology 149(Pt 11): 3193-3202.
  19. Lee, S. H., Jung, J. U. and Means, R. E. (2003). 'Complementing' viral infection: mechanisms for evading innate immunity. Trends Microbiol 11(10): 449-452.
  20. Gwack, Y., Nakamura, H., Lee, S. H., Souvlis, J., Yustein, J. T., Gygi, S., Kung, H. J. and Jung, J. U. (2003). Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Mol Cell Biol 23(22): 8282-8294.
  21. Gwack, Y., Baek, H. J., Nakamura, H., Lee, S. H., Meisterernst, M., Roeder, R. G. and Jung, J. U. (2003). Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol 23(6): 2055-2067.
  22. Feng, P., Park, J., Lee, B. S., Lee, S. H., Bram, R. J. and Jung, J. U. (2002). Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J Virol 76(22): 11491-11504.
  23. Lee, S. H., Cheung, M., Irani, V., Carroll, J. D., Inamine, J. M., Howe, W. R. and Maslow, J. N. (2002). Optimization of electroporation conditions for Mycobacterium avium. Tuberculosis (Edinb) 82(4-5): 167-174.
  24. Hazra, R., Lee, S. H., Maslow, J. N. and Husson, R. N. (2000). Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis. J Infect Dis 181(4): 1298-1303.
  25. Lipson, S. M., Falk, L. H. and Lee, S. H. (1996). Effect of leukocyte concentration and inoculum volume on the laboratory identification of cytomegalovirus in peripheral blood by the centrifugation culture-antigen detection methodology. Arch Pathol Lab Med 120(1): 53-56.
  26. Lee, S. H., Biondo, F. X., Teichberg, S. and Lipson, S. M. (1996). Aluminosilicates enhance the infectivity of cytomegalovirus in urine using centrifugation-enhanced antigen detection technology. Zentralbl Bakteriol 283(4): 502-514.
  27. Lipson, S. M., Ashraf, A. B., Lee, S. H., Kaplan, M. H. and Shepp, D. H. (1995). Cell culture-PCR technique for detection of infectious cytomegalovirus in peripheral blood. J Clin Microbiol 33(5): 1411-1413.
  28. Lee, J., Lee, S. and Sanger, H. (1990). Viroid diseases occurring on Korean hop plants. Korean Journal of Plant Pathology 6(2): 256-260.
1 Protocol published
Flow Cytometric Analysis of Calcium Influx Assay in T cells
Author:  Sun-Hwa Lee, date: 09/20/2013, view: 6580, Q&A: 0
Calcium influx is one of the key signaling events upon stimulation of T cell receptors (TCR) and plays an important role for T cell activation, proliferation, and differentiation. Phorbol myristate acetate (PMA) and calcium ionophore ionomycin are ...