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Coauthors
Laurent Reber Laboratory of Therapeutic Innovation, UMR7200, Faculty of Pharmacy, University of Strasbourg, France
3 protocols

François Daubeuf Laboratory of Therapeutic Innovation, UMR7200, Faculty of Pharmacy, University of Strasbourg, France
3 protocols

Nelly Frossard
  • Laboratory of Therapeutic Innovation, UMR7200, Faculty of Pharmacy, University of Strasbourg, France
Contributions
  • 3 Author merit

Education

Ph.D. in Molecular and Cellular Pharmacology, Université Louis Pasteur, Strasbourg I, 1981

Current position

Nelly Frossard is a Co-head of "Integrative Chemical Biology" team 1, Laboratory of Therapeutic Innovation, UMR 7200 CNRS / Strasbourg University (Pr M. Hibert)

Publications

  1. Benahmed, M. A., Elbayed, K., Daubeuf, F., Santelmo, N., Frossard, N. and Namer, I. J. (2014). NMR HRMAS spectroscopy of lung biopsy samples: Comparison study between human, pig, rat, and mouse metabolomics. Magn Reson Med 71(1): 35-43.
  2. Daubeuf, F. and Frossard, N. (2013). Acute asthma models to ovalbumin in the mouse. Curr Protoc Mouse Biol 3: 1-7.
  3. Reber, L. L., Daubeuf, F., Nemska, S. and Frossard, N. (2012). The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma. PLoS ONE 7(11): e49512.
  4. Reber, L. L., Daubeuf, F., Plantinga, M., De Cauwer, L., Gerlo, S., Waelput, W., Van Calenbergh, S., Tavernier, J., Haegeman, G., Lambrecht, B. N., Frossard, N.* and De Bosscher, K.* (2012). A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma. J Immunol 188(7): 3478-3487. (*equivalent last author)
  5. Gasparik, V., Daubeuf, F., Hachet-Haas, M., Rohmer, F., Gizzi, P., Haiech, J., Galzi, J. L., Hibert, M., Bonnet, D. and Frossard, N. (2012). Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo. ACS Med Chem Lett 3(1): 10-14.
  6. Daubeuf, F. and Frossard, N. (2012). Performing bronchoalveolar lavage in the mouse. Curr Protoc Mouse Biol 2: 1-8.
  7. (2012). Why and how to find neutraligands targeting chemokines? Drug Discov Today Technol 9(4): e227-314.
  8. Freund-Michel, V., Muller, B. and Frossard, N. (2011). Expression and role of the TrkA receptor in pulmonary inflammatory diseases. In “Inflammatory diseases – A modern perspective”, In: Amit Nagal(eds), InTech publisher, pp. 75-100.
  9. Benahmed, M. A., Santelmo, N., Elbayed, K., Frossard, N., Noll, E., Canuet, M., Pottecher, J., Diemunsch, P., Piotto, M., Massard, G. and Namer, I. J. (2012). The assessment of the quality of the graft in an animal model for lung transplantation using the metabolomics 1H high-resolution magic angle spinning NMR spectroscopy. Magn Reson Med 68(4): 1026-1038.
  10. Deschamps, K., Cromlish, W., Weicker, S., Lamontagne, S., Huszar, S. L., Gauthier, J. Y., Mudgett, J. S., Guimond, A., Romand, R., Frossard, N., Percival, M. D., Slipetz, D. and Tan, C. M. (2011). Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma. Am J Respir Cell Mol Biol 45(1): 81-87.
  11. Hachet-Haas, M., Bonnet, D., Daubeuf, F., Hibert, M., Haiech, J., Frossard, N. and Galzi , J. L.(2011). Les neutraligands à l’assaut des chimiokines. Biofutur, 30/319, 52-55.
  12. Galzi, J. L., Hachet-Haas, M., Bonnet, D., Daubeuf, F., Lecat, S., Hibert, M., Haiech, J. and Frossard, N. (2010). Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications. Pharmacol Ther 126(1): 39-55.
  13. Reber, L., Vermeulen, L., Haegemann, G. and Frossard, N. (2009) Mitogen- and Stress-activated protein Kinase (MSK)1-mediated NFkB phosphorylation is necessary for IL-1β-induced stem cell factor (SCF) expression. PloS One 4(2):e4393.
  14. Zhang, Z., Hener, P., Frossard, N., Kato, S., Metzger, D., Li, M. and Chambon, P. (2009). Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A 106(5): 1536-1541.
  15. Freund-Michel, V. and Frossard, N. (2008). Overexpression of functional TrkA receptors after internalisation in human airway smooth muscle cells. Biochim Biophys Acta 1783(10): 1964-1971.
  16. Freund-Michel, V. and Frossard, N. (2008). The nerve growth factor and its receptors in airway inflammatory diseases. Pharmacol Ther 117(1): 52-76.
  17. Ble, F. X., Cannet, C., Zurbruegg, S., Karmouty-Quintana, H., Bergmann, R., Frossard, N., Trifilieff, A. and Beckmann, N. (2008). Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging. Radiology 248(3): 834-843.
  18. Hachet-Haas, M., Balabanian, K., Rohmer, F., Pons, F., Franchet, C., Lecat, S., Chow, K. Y., Dagher, R., Gizzi, P., Didier, B., Lagane, B., Kellenberger, E., Bonnet, D., Baleux, F., Haiech, J., Parmentier, M., Frossard, N., Arenzana-Seisdedos, F., Hibert, M. and Galzi, J. L. (2008). Small neutralizing molecules to inhibit actions of the chemokine CXCL12. J Biol Chem 283(34): 23189-23199.
3 Protocols published
Measurement of Airway Responsiveness in the Anesthetized Mouse
Authors:  François Daubeuf, Laurent Reber and Nelly Frossard, date: 04/05/2013, view: 6301, Q&A: 0
Airway hyperresponsiveness to methacholine is an important characteristic of asthma. Many devices can be used to measure airway responsiveness in the mouse but it is well established that the invasiveness of a measurement technique is correlated ...
Allergen Sensitization and Challenge to Ovalbumin
Authors:  François Daubeuf, Laurent Reber and Nelly Frossard, date: 04/05/2013, view: 7567, Q&A: 0
This protocol describes the sensitization and challenge of mice with ovalbumin for use as an acute murine model of asthma. This protocol induces reproducible airway inflammation and remodelling, and bronchial hyperresponsiveness to methacholine as ...