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Coauthors
Hexin Chen Department of Biological Science, University of South Carolina, USA
3 protocols

Sara Johnson University of South Carolina
2 protocols

Pang-Kuo Lo
  • Biological Sciences Department, University of South Carolina, USA
  • 2 Author merit

Education

Ph.D. in Biochemistry and Molecular Biology, National Yang-Ming University, 1999, Taipei, Taiwan

Current position

Research Assistant Professor, Department of Biological Sciences, University of South Carolina, USA

Publications

  1. Lo, P. K.*, Lee, J. S., Chen, H., Reisman, D., Berger, F. G. and Sukumar, S. (2013). Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas. Exp Mol Pathol 94(1): 262-269. (*corresponding author).
  2. Lo, P. K., Kanojia, D., Liu, X., Singh, U. P., Berger, F. G., Wang, Q. and Chen, H. (2012). CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFbeta signaling. Oncogene 31(21): 2614-2626.
  3. Lo, P. K.*, Lee, J. S. and Sukumar, S.* (2012). The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. Cell Signal 24(1): 316-324. (*corresponding author)
  4. Lo, P. K., Lee, J. S., Liang, X., Han, L., Mori, T., Fackler, M. J., Sadik, H., Argani, P., Pandita, T. K. and Sukumar, S. (2010). Epigenetic inactivation of the potential tumor suppressor gene FOXF1 in breast cancer. Cancer Res 70(14): 6047-6058.
  5. Lo, P. K., Watanabe, H., Cheng, P. C., Teo, W. W., Liang, X., Argani, P., Lee, J. S. and Sukumar, S. (2009). MethySYBR, a novel quantitative PCR assay for the dual analysis of DNA methylation and CpG methylation density. J Mol Diagn 11(5): 400-414.
  6. Lo, P. K. and Sukumar, S. (2008). Epigenomics and breast cancer. Pharmacogenomics 9(12): 1879-1902.
  7. Lo, P. K., Mehrotra, J., D'Costa, A., Fackler, M. J., Garrett-Mayer, E., Argani, P. and Sukumar, S. (2006). Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. Cancer Biol Ther 5(3): 281-286.
  8. Lo, P. K., Huang, S. Z., Chen, H. C. and Wang, F. F. (2004). The prosurvival activity of p53 protects cells from UV-induced apoptosis by inhibiting c-Jun NH2-terminal kinase activity and mitochondrial death signaling. Cancer Res 64(23): 8736-8745.
  9. Lo, P. K., Chen, J. Y., Tang, P. P., Lin, J., Lin, C. H., Su, L. T., Wu, C. H., Chen, T. L., Yang, Y. and Wang, F. F. (2001). Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53. J Biol Chem 276(40): 37186-37193.
  10. Lo, P. K., Chen, J. Y., Lo, W. C., Chen, B. F., Hsin, J. P., Tang, P. P. and Wang, F. F. (1999). Identification of a novel mouse p53 target gene DDA3. Oncogene 18(54): 7765-7774.
2 Protocols published
Isolation of Cancer Epithelial Cells from Mouse Mammary Tumors
Authors:  Sara Johnson, Hexin Chen and Pang-Kuo Lo, date: 02/05/2013, view: 7895, Q&A: 0
The isolation of cancer epithelial cells from mouse mammary tumor is accomplished by digestion of the solid tumor. Red blood cells and other contaminates are removed using several washing techniques such that primary epithelial cells can further ...
In vitro Tumorsphere Formation Assays
Authors:  Sara Johnson, Hexin Chen and Pang-Kuo Lo, date: 02/05/2013, view: 29388, Q&A: 3
A tumorsphere is a solid, spherical formation developed from the proliferation of one cancer stem/progenitor cell. These tumorspheres (Figure 1a) are easily distinguishable from single or aggregated cells (Figure 1b) as the cells appear to become ...