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Coauthors
Anne Davidson Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, USA
2 protocols

Alamelu Raja Department of Immunology, Tuberculosis Research Center (ICMR), India
2 protocols

Uma Ranganathan Department of Pediatrics (Infectious Diseases), Albert Einstein College of Medicine, USA
3 protocols
Coreviewers
Benoit Chassaing Georgia State University
11 protocols

Ivan Zanoni Harvard Medical School
64 protocols

Jia Li SRI International
37 protocols

Ruth Franklin Yale University
6 protocols

Ramalingam Bethunaickan
  • Faculty, Feinstein Institute for Medical Research
Research focus
  • Immunology
  • 3 Author merit

Education

Ph.D, Tuberculosis Research Center/ TN MGR University-chennai, 2003

Publications

Publication as First Author and/or Corresponding Author in indexed journals



1. Rajasekaran S, Anuradha R, Manokaran G and Bethunaickan R. An overview of Lymphatic Filariasis Lymphedema. .Lymphology 2017: accepted July 2017.

2. Pathakumari B, Bethunaickan R. Biomarker and Therapeutic Targets for Tuberculosis: Role of Micro RNAs. J. Investig. Genomics. 2016:3(3): 00050. DOI: 10.15406/jig.2016.03.00050

3. Bethunaickar R, Berthier CC, Zhang W,Eksi R, Li H, Guan Y, Kretzler M, and Davidson A. Identification of stage specific genes associated with lupus nephritis and response to remission induction in NZB/W and NZM2410 mice. Arthritis Rheum. 2014. 66(8):2246-58: PMID: 24757019 (IF:7.866)

4. Bethunaickan R, Berthier C, Zhang W, Kretzler M, and Davidson A. Comparative transcriptional profiling of 3 murine models of SLE nephritis reveals both unique and shared regulatory networks. PLoS ONE - 01/2013; 8(10):e77489. PMID: 24167575 (IF: 4.09; Cited 01 time)

5. Bethunaickan R, Sahu R, Liu Z, Tang YT, Huang W, Edegbe O, Tao H, Ramanujam M, Madaio MP and Davidson A. Anti-TNF treatment of IFN induced lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation. Arthritis Rheum. 2012: 64 (10):3399–3408. PMID: 22674120 (IF:7.866; Cited 06 times)

6. Bethunaickan R, Sahu R and Davidson A. Analysis of renal mononuclear phagocytes in murine models of SLE. Methods Mol Biol. 2012; 900:207-32. PMID: 22933071 (IF: 1.29)

7. Berthier C *, Bethunaickan R *, Gonzalez-Rivera T *, Nair V, Ramanujam M, Zhang W, Bottinger EP, Segerer S, Cohen CD, Davidson A, and Kretzler M. Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis. The Journal of Immunology. 2012: 189: 988-1001.PMID:22723521. (IF: 5.78; Cited 12 times) (* - Authors contributed equally to the work)

8. Bethunaickan, R. and Davidson, A. Process and Analysis of Kidney Infiltrates by Flow Cytometry from Murine Lupus Nephritis. Bio-protocol. 2012; 2(9): e167. http://www.bio-protocol.org/e167

9. Bethunaickan, R. and Davidson, A. (2012). Isolation of Dendritic Cells and Macrophages from the Murine Kidneys of Lupus by Cell Sorter. Bio-protocol. 2012;2(8): e168. http://www.bio-protocol.org/e168

10. Bethunaickan R, Berthier C, Ramanujam M, Sahu R, Zhang W, Sun Y, Bottinger E, Ivashkiv L, Kretzler M, and Davidson A. A unique hybrid renal mononuclear phagocyte activation phenotype in murine SLE Nephritis. The Journal of Immunology. 2011; 186; 4994-5003.PMID:21411733. (IF: 5.78; Cited 27 times)

11. Ramalingam Bethunaickan, Alain R. Baulard, Camille Locht and Raja A. Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis. Scand J. Infect Dis. 2007;39(10):867-874.PMID: 17852894. (IF: 1.722; Cited 12 times)
12. Ramalingam B, Alain R. Baulard, Camille Locht , Narayanan PR and Raja A. Cloning expression and purification of the 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis. Protein Expression and Purification. 2004; 36 (1):53-60.PMID:15177284. (IF: 1.587;Cited 15 times)

13. Ramalingam B, Uma Devi KR, and Raja A. Isotype-specific anti-38 and 27 kDa (mpt 51) response in pulmonary tuberculosis with human immunodeficiency virus coinfection. Scand J. Infect Dis. 2003; 35(4):234-239.PMID:12839150. (IF: 1.722;Cited 26 times)

14. Ramalingam B, Uma Devi KR, Soumya Swaminathan and Alamelu Raja. Isotype specific antibody response in childhood tuberculosis against purified 38kDa antigen of Mycobacterium tuberculosis. Journal of Tropical Pediatrics. 2002, 48 (3): 188–189. PMID:12164607. (IF: 1.388; Cited 06 times)


9.2 Publication as Co-author in indexed journals

1. Chandrasekaran P, Saravanan N, Bethunaickan R and Tripathy S. MALNUTRITION: Modulator of Immune Responses in Tuberculosis. Frontiers in Immunology. Accepted. Aug.2017.

2. Sivaprakasam R, Anuradha R, Bethunaickan R, and Manoharan G. Multi modality treatment for the near normal of Grade IV lymphedema – a Case Study. 2017. Accepted July17.


3. Davidson A, Bethunaickan R, Berthier C, Sahu R, Zhang W, Kretzler M. Molecular studies of lupus nephritis kidneys. 2015; Immunol. Res. Sept. 16. PMID: 26376897

4. Boneparth A, Huang W, Bethunaickan R, Woods M. Sahu R, Arora S, Akerman M, Lesser M and Davidson A. TLR7 influences germinal center selection in murine SLE. PLoS ONE. 2015; 10(3); e0119925. PMID:25794167.

5. Sahu R, Bethunaickan R, Singh S and Davidson A. Structure and function of renal macrophages and dendritic cells from SLE prone mice. Arthritis Rheum. 2013:66(6):1596-1607. PMID: 24866269 (IF:7.866; Cited 01 time)


6. Liu Z, Bethunaickan R, Sahu R, Brenner M, Laragione T, Gulko PS, Davidson A.The multiple chemokine-binding Bovine Herpersvirus 1 Glycoprotein G (BHVIgG) inhibits polymorphonuclear cell by not monocyte migration into inflammatory sites.Mol Med. 2013. 19: 276-285.PMID: 23979709 (IF: 4.469)

7. Mosini I, Huang W, Bethunaickan R, Sahu R, Ricketts PG, Akerman M, Eilat D, Lesser M, Davidson A. The Yaa locus and IFNα fine tune germinal center B cell selection in murine SLE. The Journal of Immunology. 2012: 189: 4305–4312. PMID: 23024275 (IF: 5.78; cited 4 times)


8. Huang W, Moisini I, Bethunaickan R, Sahu R, Akerman M, Eilat D, Lesser M, Davidson A. BAFF/APRIL Inhibition Decreases Selection of Naive but Not Antigen- Induced Autoreactive B Cells in Murine Systemic Lupus Erythematosus. The Journal of Immunology. 2011: 187: 6571–6580.PMID:22102726. (IF: 5.78; Cited 09 times)

9. Liu Z, Bethunaickan R, Huang W, Ramanujam M, Madaio MP and Davidson A. Interferon-α confers resistance to SLE nephritis to therapy to NZB/W F1 mice. The Journal of Immunology. 2011: 187; 1506-1513.PMID:21705616. (IF: 5.78; Cited 17 times)


10. Liu Z, Bethunaickan R, Huang W, Lodhi U, Solano I, Madaio MP, Davidson A. Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner. Arthritis Rheum. 2011; 63(1):219-29. PMID: 20954185. (IF:7.866; Cited 35 times )


11. Ramanujam M, Bethunaickan R, Huang W, Tao H, Madaio MP, Davidson A. Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice. Arthritis Rheum. 2010 May;62(5):1457-68. PMID:20131293. (IF:7.866; Cited 56 times)

12. Kahn P, Ramanujam M, Bethunaickan R, Huang W, Tao H, Madaio MP, Factor SM, Davidson A. Prevention of murine antiphospholipid syndrome by BAFF blockade. Arthritis Rheum. 2008; 58(9):2824-34.PMID:18759321. (IF:7.866; Cited 52 times)

13. Raja A, Uma Devi KR, and Bethunaickan R. Improved diagnosis of pulmonary tuberculosis by detection of antibodies against multiple Mycobacterium tuberculosis antigens. Diagn. Microbiol. Infect. Dis. 2008:60:361-368.PMID:18206332. (IF: 2.528; Cited 26 times)

14. Schiffer L, Bethunaickan R, Ramanujam M, Huang W, Schiffer M, Tao H, M. Madaio MP, Bottinger EP, and Davidson A. Activated Renal Macrophages Are Markers of Disease Onset and Disease Remission in Lupus Nephritis. The Journal of Immunology. 2008; 180 (3):1938-1947.PMID:18209092. (IF: 5.78; Cited 105 times)


15. Srivastava V, Rouanet C, Srivastava R, Ramalingam B, Locht C, Srivastava BS.Macrophage-specific Mycobacterium tuberculosis genes: identification by green fluorescent protein and kanamycin resistance selection. Microbiology. 2007; 153(Pt 3):659-666.PMID:17322185. (IF: 3.061; Cited 35 times)

16. Alamelu Raja, Uma Devi KR, and Ramalingam B. Clinical value of specific detection of immune complex-bound antibodies in pulmonary tuberculosis. Diagn. Microbiol. Infect. Dis. 2006; 56(3):281-7.PMID:16876372. (IF: 2.528; Cited 09 times)

17. Alamelu Raja, Uma Devi KR, Ramalingam B and Patrick J. Brennan. Improved diagnosis of pulmonary tuberculosis by detection of free and immune complex bound anti – 30kDa antibodies. Diagn. Microbiol. Infect. Dis. 2004; 50 (4):253-259.PMID:15582298. (IF: 2.528; Cited 18 times)


18. Uma Devi KR, Ramalingam B and Raja A Antibody response to Mycobacterium tuberculosis 30 and 16kDa antigens in pulmonary tuberculosis with human immunodeficiency virus coinfection. Diagn. Microbiol. Infect. Dis. 2003 Jul;46(3):205-209.PMID:12867096. (IF: 2.528; Cited 24 times)


19. Uma Devi KR, Ramalingam B and Alamelu Raja. Qualitative and quantitative analysis of antibody response in childhood tuberculosis against antigens of Mycobacterium tuberculosis. Indian Journal of Medical Microbiology. 2002; 20 (3);145-149.PMID:17657054. (IF: 0.988; Cited 09 times)

20. Alamelu Raja, Uma Devi KR, Ramalingam B and Patrick J. Brennan. Immunoglobulin G, A and M responses in serum and circulating immune complexes elicited by the 16-Kilodalton antigen of Mycobacterium tuberculosis. Clinical and Diagnostic Laboratory Immunology. 2002; 9 (2): 308-312. PMID: 11874868. (IF: 2.546; Cited 69 times)

21. Uma Devi K. R., Senthil Kumar K. S., Ramalingam B and Alamelu Raja. Purification and characterization of three immunodominant proteins (38, 30 and 16 kDa) of Mycobacterium tuberculosis. Protein Expression and Purification. 2002; 24:188-195.PMID:11858712. (IF: 1.587; Cited 21 times)


22. Alamelu Raja, Uma Devi KR, Ramalingam B and Vijayasekeran D. Serologic response to a secreted (30kDa) and a cytosolic (16kDa) antigen of Mycobacterium tuberculosis in childhood tuberculosis. The Pediatric Infectious Disease Journal. 2001; 20:1161-1165.PMID:11740324. (IF: 3.577; Cited 22 times)

23. Uma Devi KR, Ramalingam B, Brennan PJ, Narayanan PR, Alamelu Raja. Specific and early detection of IgG, A and M antibodies to Mycobacterium tuberculosis 38kDa antigen in pulmonary tuberculosis. Tuberculosis. 2001; 81:249-253.PMID:11466037. (IF: 3.474; Cited 65 times)



9.3 Book chapters and conference Proceedings

Book chapter:

1. Bethunaickan R, Sahu R and Davidson A. Analysis of renal mononuclear phagocytes in murine models of SLE. Autoimmunity: Methods and protocols. Springer Protocols: Methods in Molecular Biology 900: Humana Press; 2nd edition 2012, Edited by Andras Perl, MD, Ph.D. (ISBN:978-1-60761-719-8)

Conference proceedings:

1. Meera Ramanujam, Martha Tepas, Haiou Tao, Dan Frank, Anne Davidson, Ramalingam Bethunaickan. Remission of IFN alpha induced SLE in NZB/W mice with cyclophosphamide/CTLA4Ig but not mycophenolate mofetil/CYLA4Ig. Arthritis Rheumatism. 2006; 54(9); S451.

2. Meera Ramanujam, Ramalingam Bethunaickan, Anne Davidson. Activated
Interstitial Macrophages are Important Mediators of SLE Nephritis. Clinical
Immunology. 2007.123;S88 (FOCIS-2007 meeting San Diego, June 7-11, 2007- USA)

3. Berthier C., Bethunaickan R, Bottinger E., Kretzler, M.and Davidson A. Proliferative SLE Nephritis and Progressive Non-inflammatory Glomerulosclerosis share key Gene Expression Profiles. (American College of Rheumatology scientific meeting October 24-29, 2008)

4. Ramanujam M. Bethunaickan R, Bottinger E and Davidson A. Analysis of Activated Renal Macrophages And Dendritic Cells In SLE Nephritis. (American College of Rheumatology scientific meeting October 24-29, 2008)

5. Ramalingam Bethunaickan, Meera Ramanujam, Haiou Tao and Anne Davidson
Mononuclear Phagocytes That Upregulate ITGAM Are Markers of SLE
Nephritis Onset and Remission Sunday, October 18, 2009: (American College of
Rheumatology scientific meeting October 16-21, 2009, Philadelphia)

6. Zheng Liu, Ramalingam Bethunaickan, Weiqing Huang and Anne Davidson.IFN_ Induced SLE in NZB/W Mice Is T Cell Dependent but Blockade of TFH Does Not Prevent Disease. Arthritis rheumatism: 2010; Vol.62:5:S918 (American College of Rheumatology scientific meeting November 7-11, 2010, Atlanta.)

7. Tania C. Gonzalez Rivera, Celine C. Berthier, Viji Nair, Ramalingam Bethunaickan, Matthias Kretzler, Anne Davidson and ERCB Consortium . Transcriptional Inflammatory Mechanism in Murine Lupus Nephritis: An Insight into Human Disease. Arthritis and Rheumatism; 2010; 62:5:S958 (American College of Rheumatology scientific meeting November 7-11, 2010, Atlanta.)

8. Ramalingam Bethunaickan, Yiting Tang and Anne Davidson. TNF Inhibition Prevents Peri-Glomerular Resident Renal Macrophage Accumulation and Activation in SLE Nephritis . 2011:63; 10; S213 (American College of Rheumatology scientific meeting Chicago, Illinois November 4-9, 2011. )

9. Huang W., Moisini I., Bethunaickan R., Sahu R. Akerman, M Lesser M., Eilat D., Davidson A.BAFF/APRIL Inhibition Induces Negative Selection of Naı¨ve Autoreactive B Cells but Does Not Prevent Positive Selection of Autoreactive B Cells in the Germinal Center. 2011:63;10; S998 (American College of Rheumatology scientific meeting Chicago, Illinois November 4-9, 2011. )

10. Ramalingam Bethunaickan, Celine C. Berthier, Matthias Kretzler and Anne Davidson. Shared and Unique Molecular Features of Nephritis in 3 Models of Murine SLE. Arthritis and Rheumatism 2012:64:10:S621. (American College of Rheumatology scientific meeting November 9-14, 2012, Washington DC. USA.)

11. Ranjit Sahu, Ramalingam Bethunaickan and Anne Davidson. Characterization of Renal Mononuclear Phagocyte Populations in Murine SLE Nephritis Arthritis and Rheumatism. 2012:64:10:S624. (American College of Rheumatology scientific meeting November 9-14, 2012, Washington DC. USA.)

12. Alexis Boneparth , Ramalingam Bethunaickan, Weiqing Huang and Anne Davidson. Effects Of BAFF Inhibition On B Cell Selection In Murine SLE. Arthritis and Rheumatism.2013:65:10:S1196. (American College of Rheumatology scientific meeting October 25-30, 2013, San Diego, USA)

13. Ramalingam Bethunaickan, Celine C. Berthier, Hong-dong Li, Weijia Zhang, Yuanfang Guan, Matthias Kretzler and Anne Davidson. Identification Of Stage Specific Genes Associated With Lupus Nephritis and Response To Remission induction In NZB/W Mice. Arthritis and Rheumatism.2013:65:10:S241.( American College of Rheumatology scientific meeting October 25-30, 2013, San Diego, USA)

14. Weiqing Huang, Megan Woods, Alexis Boneparth, Ramalingam Bethunaickan, Ranjit Sahu and Anne Davidson. TLR7 Influences Autoreactive B Cell Selection in the Germinal Center. Arthritis and Rheumatism.2014:66:10:S1254. (American College of Rheumatology scientific meeting. November 14-19, Boston, USA)

15. Mishra R, Bethunaickan R, Zhang W, Davidson A. Disturbance of Renal Circadian Rhythm in Lupus Nephritis. Arthritis Rheumatol. 2016; 68 (suppl 10). http://acrabstracts.org/abstract/disturbance-of-renal-circadian-rhythm-in-lupus-nephritis/. Accessed October 18, 2016.
16. Mishra R, Bethunaickan R, Zhang W, Davidson A. Disturbance of Renal Circadian Rhythm in Lupus Nephritis. Journal of Immunology. 2017; 68 (suppl 10).. Accessed October 18, 2016.

3 Protocols published
Isolation of Circulating Immune Complexes from TB Patient Serum for Serodiagnosis
Authors:  Uma Devi Ranganathan, Ramalingam Bethunaickan and Alamelu Raja, date: 06/05/2012, view: 7397, Q&A: 0
Estimation of circulating immune complex in tuberculosis patients has shown better insight to the infection. Isolating circulating immune complex helps quantifying both antigen and antibody in the serum. It’s a simple procedure to improve the ...
Isolation of Dendritic Cells and Macrophages from the Murine Kidneys of Lupus by Cell Sorter
Authors:  Ramalingam Bethunaickan and Anne Davidson, date: 04/20/2012, view: 14785, Q&A: 0
Methods for the isolation and characterization of mononuclear phagocytes from the kidneys of mice with SLE are essential to understand the patho-physiology of the disease. Activation of these cells is associated with the onset of clinical disease in ...
7 Protocols reviewed
Isolation and Infection of Drosophila Primary Hemocytes
Authors:  Charles Tracy and Helmut Krämer, date: 06/05/2017, view: 1330, Q&A: 0
Phagocytosis of invading pathogens and their subsequent clearance in lysosomes is important for organismal fitness. We have devised the following protocol to extract phagocytic hemocytes from wild-type and mutant Drosophila larvae and ...
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Endophytic Microbial Community DNA Extraction from the Plant Phyllosphere
Authors:  Carlos A. Ruiz-Pérez and María Mercedes Zambrano, date: 02/20/2017, view: 1642, Q&A: 1
The plant phyllosphere, which represents all plant parts that are above the ground, is considered one of the most extensive ecosystems to be colonized by microorganisms, both at the surface as epiphytes or as endophytes within the plant. These ...
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