Education
Ph.D. in Immunology, University of Science and Technology of China 2006.
Current position
Research Scientist at The Rockefeller University, Aaron Diamond AIDS Research Center, New York, NY USA.
Publications
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Huang, J., Li, X., Kohno, K., Hatano, M., Tokuhisa, T., Murray, P. J., Brocker, T. and Tsuji, M. (2013). Generation of tissue-specific H-2Kd transgenic mice for the study of K(d)-restricted malaria epitope-specific CD8+ T-cell responses in vivo. J Immunol Methods 387(1-2): 254-261.
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Li, X., Polacino, P., Garcia-Navarro, R., Hu, S. L. and Tsuji, M. (2012). Peripheral blood invariant natural killer T cells of pig-tailed macaques. PLoS ONE 7(10): e48166.
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Avci, F. Y.*, Li, X.*, Tsuji, M. and Kasper, D. L. (2012). Isolation of carbohydrate-specific CD4(+) T cell clones from mice after stimulation by two model glycoconjugate vaccines. Nat Protoc 7(12): 2180-2192. *Co-first author
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Webb, T. J., Li, X., Giuntoli, R. L., 2nd, Lopez, P. H., Heuser, C., Schnaar, R. L., Tsuji, M., Kurts, C., Oelke, M. and Schneck, J. P. (2012). Molecular identification of GD3 as a suppressor of the innate immune response in ovarian cancer. Cancer Res 72(15): 3744-3752.
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Rai, U., Huang, J., Mishra, S., Li, X., Shiratsuchi, T. and Tsuji, M. (2012). A New Method to Determine Antigen-Specific CD8+ T Cell Activity in Vivo by Hydrodynamic Injection. Biomolecules 2(1): 23-33.
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Mishra, S., Rai, U., Shiratsuchi, T., Li, X., Vanloubbeeck, Y., Cohen, J., Nussenzweig, R. S., Winzeler, E. A., Tsuji, M. and Nussenzweig, V. (2011). Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. Vaccine 29(43): 7335-7342.
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Avci, F. Y., Li, X., Tsuji, M. and Kasper, D. L. (2011). A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat Med 17(12): 1602-1609.
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Kinjo, Y., Illarionov, P., Vela, J. L., Pei, B., Girardi, E., Li, X., Li, Y., Imamura, M., Kaneko, Y., Okawara, A., Miyazaki, Y., Gomez-Velasco, A., Rogers, P., Dahesh, S., Uchiyama, S., Khurana, A., Kawahara, K., Yesilkaya, H., Andrew, P. W., Wong, C. H., Kawakami, K., Nizet, V., Besra, G. S., Tsuji, M., Zajonc, D. M. and Kronenberg, M. (2011). Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 12(10): 966-974.
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Padte, N. N., Li, X., Tsuji, M. and Vasan, S. (2011). Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant. Clin Immunol 140(2): 142-151.
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Renukaradhya, G. J., Manickam, C., Khatri, M., Rauf, A., Li, X., Tsuji, M., Rajashekara, G. and Dwivedi, V. (2011). Functional invariant NKT cells in pig lungs regulate the airway hyperreactivity: a potential animal model. J Clin Immunol 31(2): 228-239.
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Li, X., Fujio, M., Imamura, M., Wu, D., Vasan, S., Wong, C. H., Ho, D. D. and Tsuji, M. (2010). Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant. Proc Natl Acad Sci U S A 107(29): 13010-13015.
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Lombardi, V., Stock, P., Singh, A. K., Kerzerho, J., Yang, W., Sullivan, B. A., Li, X., Shiratsuchi, T., Hnatiuk, N. E., Howell, A. R., Yu, K. O., Porcelli, S. A., Tsuji, M., Kronenberg, M., Wilson, S. B. and Akbari, O. (2010). A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. J Immunol 184(4): 2107-2115.
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Horowitz, A., Li, X., Poles, M. A. and Tsuji, M. (2009). Use of immobilized HLA-A2:Ig dimeric proteins to determine the level of epitope-specific, HLA-restricted CD8(+) T-cell response. Scand J Immunol 70(5): 415-422.
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Li, X., Shiratsuchi, T., Chen, G., Dellabona, P., Casorati, G., Franck, R. W. and Tsuji, M. (2009). Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells. J Immunol 183(7): 4415-4421.
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Li, X., Chen, G., Garcia-Navarro, R., Franck, R. W. and Tsuji, M. (2009). Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells. Immunology 127(2): 216-225.
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Liang, P. H., Imamura, M., Li, X., Wu, D., Fujio, M., Guy, R. T., Wu, B. C., Tsuji, M. and Wong, C. H. (2008). Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production. J Am Chem Soc 130(37): 12348-12354.
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Huang, Y., Chen, A., Li, X., Chen, Z., Zhang, W., Song, Y., Gurner, D., Gardiner, D., Basu, S., Ho, D. D. and Tsuji, M. (2008). Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, alpha-galactosylceramide. Vaccine 26(15): 1807-1816.
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Li, X., Yang, X., Li, L., Liu, H. and Liu, J. (2006). A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 gene enhanced potency of HBV DNA vaccine. Vaccine 24(16): 3321-3331.
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Li, X., Yang, X., Jiang, Y. and Liu, J. (2005). A novel HBV DNA vaccine based on T cell epitopes and its potential therapeutic effect in HBV transgenic mice. Int Immunol 17(10): 1293-1302.
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Li, W. F., Chen, L., Li, X. M. and Liu, J. (2005). A C-type lectin-like protein from Agkistrodon acutus venom binds to both platelet glycoprotein Ib and coagulation factor IX/factor X. Biochem Biophys Res Commun 332(3): 904-912.
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Cheng, X., Xu, Z. Y., Liu, Q. D., Li, X. M., Li, X. Y. and Liu, J. (2000). Purification and Characterization of a Platelet Agglutinating Inhibiting Protein (Agkisacutacin) from Agkistrodon acutus Venom. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32(6): 653-656.