Education

Ph.D. in Medical Biology, Department of Medical Genetics, Medical University of Lublin, Poland, 1995

Current position

Associate Professor, Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA

Publications

1. Day, J., Savani, S., Krempley, B. D., Nguyen, M. and Kitlinska, J. B. (2016). Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Am J Stem Cells 5(1): 11-18.

2. Tilan, J. and Kitlinska, J. (2016). Neuropeptide Y (NPY) in tumor growth and progression: Lessons learned from pediatric oncology. Neuropeptides 55: 55-66.

3. Paiva, S. P., Veloso, C. A., Campos, F. F., Carneiro, M. M., Tilan, J. U., Wang, H., Umans, J. G., Zukowska, Z. and Kitlinska, J. (2016). Elevated levels of neuropeptide Y in preeclampsia: A pilot study implicating a role for stress in pathogenesis of the disease. Neuropeptides 55: 127-135.

4. Hong, S. H., Tilan, J. U., Galli, S., Izycka-Swieszewska, E., Polk, T., Horton, M., Mahajan, A., Christian, D., Jenkins, S., Acree, R., Connors, K., Ledo, P., Lu, C., Lee, Y. C., Rodriguez, O., Toretsky, J. A., Albanese, C. and Kitlinska, J. (2015). High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases. Oncotarget 6(9): 7151-7165.

5. Czarnecka, M., Trinh, E., Lu, C., Kuan-Celarier, A., Galli, S., Hong, S. H., Tilan, J. U., Talisman, N., Izycka-Swieszewska, E., Tsuei, J., Yang, C., Martin, S., Horton, M., Christian, D., Everhart, L., Maheswaran, I. and Kitlinska, J. (2015). Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance. Oncogene 34(24): 3131-3143.

6. Tilan, J. U., Krailo, M., Barkauskas, D. A., Galli, S., Mtaweh, H., Long, J., Wang, H., Hawkins, K., Lu, C., Jeha, D., Izycka-Swieszewska, E., Lawlor, E. R., Toretsky, J. A. and Kitlinska, J. B. (2015). Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in patients with Ewing sarcoma--associations with tumor phenotype and survival. Cancer 121(5): 697-707.

7. Tilan, J. U., Lu, C., Galli, S., Izycka-Swieszewska, E., Earnest, J. P., Shabbir, A., Everhart, L. M., Wang, S., Martin, S., Horton, M., Mahajan, A., Christian, D., O'Neill, A., Wang, H., Zhuang, T., Czarnecka, M., Johnson, M. D., Toretsky, J. A. and Kitlinska, J. (2013). Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget 4(12): 2487-2501.

8. Tilan, J. U., Everhart, L. M., Abe, K., Kuo-Bonde, L., Chalothorn, D., Kitlinska, J., Burnett, M. S., Epstein, S. E., Faber, J. E. and Zukowska, Z. (2013). Platelet neuropeptide Y is critical for ischemic revascularization in mice. FASEB J 27(6): 2244-2255.

9. Han, R., Li, A., Li, L., Kitlinska, J. B. and Zukowska, Z. (2012). Maternal low-protein diet up-regulates the neuropeptide Y system in visceral fat and leads to abdominal obesity and glucose intolerance in a sex- and time-specific manner. FASEB J 26(8): 3528-3536.

10. Han, R., Kitlinska, J. B., Munday, W. R., Gallicano, G. I. and Zukowska, Z. (2012). Stress hormone epinephrine enhances adipogenesis in murine embryonic stem cells by up-regulating the neuropeptide Y system. PLoS One 7(5): e36609.

11. Tilan, J., Czarnecka, M. and Kitlinska, J. (2012). Sympathetic signaling in angiogenesis: implications for cancer progression. Current Cancer Therapy Reviews, 8(2):83-89.

12. Czarnecka, M., Tilan, J. and Kitlinska, J. (2012). Sympathetic neurotransmitters in neuroblastoma - between physiology and pathology. In: Shimada, H. (ed). Neuroblastoma – Present and Future.

13. Lu, C., Tilan, J. U., Everhart, L., Czarnecka, M., Soldin, S. J., Mendu, D. R., Jeha, D., Hanafy, J., Lee, C. K., Sun, J., Izycka-Swieszewska, E., Toretsky, J. A. and Kitlinska, J. (2011). Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy. J Biol Chem 286(31): 27494-27505.

14. Li, L., Najafi, A. H., Kitlinska, J. B., Neville, R., Laredo, J., Epstein, S. E., Burnett, M. S. and Zukowska, Z. (2011). Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. J Cardiovasc Transl Res 4(3): 351-362.

15. Lu, C., Everhart, L., Tilan, J., Kuo, L., Sun, C. C., Munivenkatappa, R. B., Jonsson-Rylander, A. C., Sun, J., Kuan-Celarier, A., Li, L., Abe, K., Zukowska, Z., Toretsky, J. A. and Kitlinska, J. (2010). Neuropeptide Y and its Y2 receptor: potential targets in neuroblastoma therapy. Oncogene 29(41): 5630-5642.

16. Tilan, J. and Kitlinska, J. (2010). Sympathetic Neurotransmitters and Tumor Angiogenesis-Link between Stress and Cancer Progression. J Oncol 2010: 539706.

17. Pons, J., Kitlinska, J., Jacques, D., Perreault, C., Nader, M., Everhart, L., Zhang, Y. and Zukowska, Z. (2008). Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth. Can J Physiol Pharmacol 86(7): 438-448.

18. Kuo, L. E., Czarnecka, M., Kitlinska, J. B., Tilan, J. U., Kvetnansky, R. and Zukowska, Z. (2008). Chronic stress, combined with a high-fat/high-sugar diet, shifts sympathetic signaling toward neuropeptide Y and leads to obesity and the metabolic syndrome. Ann N Y Acad Sci 1148: 232-237.

19. Kuo, L. E., Kitlinska, J. B., Tilan, J. U., Li, L., Baker, S. B., Johnson, M. D., Lee, E. W., Burnett, M. S., Fricke, S. T., Kvetnansky, R., Herzog, H. and Zukowska, Z. (2007). Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 13(7): 803-811.

20. Kuo, L. E., Kitlinska, J. B., Tilan, J. U., Li, L., Baker, S. B., Johnson, M. D., Lee, E. W., Burnett, M. S., Fricke, S. T., Kvetnansky, R., Herzog, H. and Zukowska, Z. (2007). Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 13(7): 803-811.

21. Kitlinska, J. (2007). Neuropeptide Y (NPY) in neuroblastoma: effect on growth and vascularization. Peptides 28(2): 405-412.

22. Kitlinska, J. and Zukowska, Z. (2007). Neuropeptide Y: neurogenic mediator of angiogenesis and arteriogenesis. In: Simons, M. and Rubanyi, G. (eds). Modern Concepts in Angiogenesis. Imperial College Press, London.

23. Kitlinska, J., Kuo, L., Abe, K., Pons, J., Yu, M., Li, L., Tilan, J., Toretsky, J. and Zukowska, Z. (2006). Role of neuropeptide Y and dipeptidyl peptidase IV in regulation of Ewing's sarcoma growth. Adv Exp Med Biol 575: 223-229.

24. Kitlinska, J., Abe, K., Kuo, L., Pons, J., Yu, M., Li, L., Tilan, J., Everhart, L., Lee, E. W., Zukowska, Z. and Toretsky, J. A. (2005). Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors. Cancer Res 65(5): 1719-1728.

25. Kitlinska, J. (2005). NPY family of tumors in regulation of growth of neural crest derived tumors. In: Zukowska, Z. and Feuerstein, G. Z. (eds). The NPY family of peptides in inflammation, immune disorders, inflammation, angiogenesis and cancer. Birkhäuser Verlag, Basel.

26. Kitlinska, J., Kuo, L. and Pons, J. (2005). NPY as a pleiotropic proliferative factor. In: Zukowska, Z. and Feuerstein, G. Z. (eds). The NPY family of peptides in inflammation, immune disorders, inflammation, angiogenesis and cancer. Birkhäuser Verlag, Basel.